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ALS overview

ALS (amyotrophic lateral sclerosis), more commonly known as Lou Gehrig’s disease, is a progressive neurodegenerative disorder that destroys the ability of muscles to function properly. Important nerve cells in the brain and spine controlling movement are gradually damaged and hardened, leading to increasing muscle atrophy.

ALS typically starts innocuously with mild muscle twitching, weakness in extremities, or possibly slurred speech. However, this develops into a total lack of muscle control, including those needed to eat and breathe. Sadly there is no known cure for this terminal illness, but treatment has been shown to improve patient comfort.

The specific signs and symptoms of ALS will differ significantly from person to person, depending on which nerve cells are impacted first. That said, they generally involve trouble doing normal daily activities, increased tripping, weakness in limbs, and muscle cramps.

But other common symptoms are less obvious, including cognitive or behavioral changes — for instance, crying, laughing, or other emotional responses at odd or inappropriate times. Symptoms usually start in the hands or feet and work toward the body.

ALS progressively damages the nerve cells, which control movement. These motor neurons extend from the brain and spinal cord to all the muscles of the body. As function gradually deteriorates over time, the body’s ability to send messages to the muscles is eventually lost.

While researchers don’t yet know what causes ALS, the best theories suggest a complex interaction between genetics and environmental factors.

The most well-established risk factor for ALS is heredity, as 5-10% of people with ALS have a family member also diagnosed. Studies of the human genome have also shown that those with ALS tend to have similar genetic variation.

The other major risk factors we understand are also things we have no control over, such as age and sex. Those between the ages of 40 and 65 have the highest risk of developing ALS, while before the age of 65, men are slightly more likely than women to have ALS.

However, researchers have identified a few key things people can do to lower their risk of developing ALS. Smoking is understood to be the biggest risk factor for ALS that can be easily controlled. That said, both environmental toxin exposure and military service have been shown to correlate with developing the condition, although researchers are split on why.

ALS is a relatively rare condition, with only 5,000 new cases being diagnosed in the US every year. That said, estimates suggest only around 16,000 people are currently living with the disease, highlighting its severity.

Given the terminal diagnosis, we must develop new and effective drugs to help slow symptom progression as much as possible. If you believe you or a loved one may be developing ALS, you must contact your doctor as soon as possible. Only they can provide the proper testing and options moving forward.

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Table of Contents

CBD Research For ALS

potencial impact research overview

ALS - Cannabis and amyotrophic lateral sclerosis: hypothetical and practical applications, and a call for clinical trials

  • University of Washington Medical Center
  • 2010

related conditions:


Researchers identified several keys ways in which Cannabis-based medication could potentially be an effective therapy for neurodegenerative disorders. They concluded that not only does CBD and cannabis offer an analgesic effect, but also muscle relaxation, appetite stimulation, and sleep induction. Even more importantly, the team showed cannabis has powerful benefits, which can even prolong cell survival.

ALS - Amyotrophic lateral sclerosis: delayed disease progression in mice by treatment with a cannabinoid

  • The Forbes Norris MDA/ALS Research and Treatment Center
  • 2004

related conditions:


The researchers tested if cannabinoids such as THC and CBD can reduce overall cell damage. The team concluded there is a distinct mechanism connecting cannabinoids and some type of neuroprotective effect. While the majority of their evidence dealt with THC, they noted the extreme likelihood other cannabinoids had a similar impact.

ALS - The (Endo)Cannabinoid System in Multiple Sclerosis and Amyotrophic Lateral Sclerosis

  • University of Rome Tor Vergata
  • 2007

related conditions:


The endocannabinoid system has been identified as readily able to control neuroinflammation and neurodegeneration. Researchers wanted to understand if the activation of endocannabinoid receptors could influence the development of neuropathic disorders. Ultimately, CBD was shown to modulate many aspects of these conditions, including neuroinflammation, microglial activation, oxidative stress, and excitotoxicity.

ALS - Survey of cannabis use in patients with amyotrophic lateral sclerosis

  • University of Washington School of Medicine
  • 2004

related conditions:


This survey of patients living with neuropathic disorders asked about how cannabis use has affected their symptoms. After surveying over 100 cannabis-using ALS patients, the team concluded CBD might be useful in reducing spasticity, depression, appetite loss, and pain. While CBD wasn’t shown to improve slurred speech, it did reduce depression symptoms for an average of 2-3 hours.

CBD Research That Might Be Useful for Symptoms of ALS

potencial impact research overview

Inflammation - Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice

  • Tongji University School of Medicine
  • 2013

related conditions:


A study of mice concluded CBD has significant anti-inflammatory effects. The researchers also saw evidence that the expression of the GPR55 receptor was improved after starting on CBD. Treatment with CBD was shown to significantly decrease the levels of several inflammation-related chemicals in test subjects.

Anxiety - Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence

  • University of Melbourne, Australia
  • 2013

related conditions:


A comprehensive review of all the plant-based medicine which has had both preclinical and human clinical trials conducted about their anxiolytic-like effect. An analysis of over 1500 papers identified 21 plants which had been adequately tested, with one of the most successful of these plants found to be CBD enriched Cannabis species.

Sleep - Cannabis, Cannabinoids, and Sleep: a Review of the Literature

  • Palo Alto University, CA, USA
  • 2017

related conditions:


This report concludes CBD holds promise for significantly increasing the quality of REM sleep. Researchers believe it could one day be a primary force behind improved overall sleep quality. CBD was even shown to reduce daytime sleepiness in many patients.

ALS & CBD Research Overview

Over a relatively short period, CBD has grown from a little known alternative medication to a popular choice for many. This is primarily because CBD provides powerful benefits, with only a few mild side-effects. Research even suggests CBD can help ease many of the symptoms of neuropathic disorders, such as ALS and MS.

A report entitled Cannabis and amyotrophic lateral sclerosis: hypothetical and practical applications, and a call for clinical trials showed strong evidence that cannabis-based medications, such as CBD, could be tolerable and effective therapies for ALS. In addition to the analgesic effect noted by many researchers, they also found evidence of muscle relaxation, appetite stimulation, and even sleep induction. However, most importantly, they saw clear evidence of cannabis medications prolonging nerve cell survival.

Another report wanted to uncover just how much protection THC and CBD provide nerve cells. Amyotrophic lateral sclerosis: delayed disease progression in mice by treatment with a cannabinoid, showed distinct evidence of an underlying mechanism connecting expression of the endocannabinoid system and a potent neuroprotective effect.

Further reports, including The (Endo)Cannabinoid System in Multiple Sclerosis and Amyotrophic Lateral Sclerosis, have attempted to determine how CBD and endocannabinoids are able to control neuroinflammation and degeneration. The researchers showed CBD modulates several vital factors on neuropathic disorders such as ALS, including microglial activation, oxidative stress, and excitotoxicity.

A survey of ALS patients who used cannabis called Survey of cannabis use in patients with amyotrophic lateral sclerosis found clear evidence of the important quality of life benefits provided by CBD. Over 100 patients were surveyed with researchers concluding CBD helped improve spasticity, depression, and appetite loss.

Other reports which aren’t directly related to ALS have still provided data CBD may be an effective treatment for some of the more common symptoms. For instance, a report called Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice offered powerful evidence that CBD reduces the levels of inflammation-related chemicals in your system. They were even able to show that expression of the GPR55 receptor was improved by CBD use.

Other common symptoms of ALS are anxiety and trouble sleeping, which can significantly reduce the quality of life. However, reports such as Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence, and Cannabis, Cannabinoids, and Sleep: a Review of the Literature, have proven CBD is a viable treatment option for both of these problems. In fact, the review of plant-based medicine identified 21 different medications that can reduce anxiety, with CBD reigning supreme.

Best CBD for ALS

Relax Full Spectrum CBD Oil (3500mg)

Relax Full Spectrum CBD Oil (3500mg)


Relax Full Spectrum CBD Oil, available with an oil tincture dropper, delivers the ideal amount of CBD to meet all of your wellness needs. Made in the USA  from 100% high quality industrial hemp, this 3500 mg bottle of CBD is perfect for those wanting to combat stress, anxiety, and chronic pain.

  • CBD Per Serving: 116.67mg
  • Number Of Servings: 30
  • Cost Per Serving: $5.60
  • Cost Per/mg of CBD: $0.05
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  • 100% Hemp Product
  • Made in USA
  • Full Spectrum
  Servings per day Days supplied in one package Cost per week
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Mid Dosage (200 mg/day) 1.71 17.5 $67.20
High Dosage (300 mg/day) 2.57 11.7 $100.80

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Everyday Optimal CBD Capsules (200mg)

Everyday Optimal CBD Capsules (200mg)


Are you looking for something stronger than almost any CBD oil product on the market? Then you’ll love the newest addition to our high potency CBD line. With each capsule containing 200mg of pure CBD, you’ll experience all-natural, long-lasting relief for tough pain, sleep problems, anxiety, and more.

  • CBD Per Serving: 200mg
  • Number Of Servings: 30
  • Cost Per Serving: $10.00
  • Cost Per/mg of CBD: $0.05
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  Servings per day Days supplied in one package Cost per week
Low Dosage (150 mg/day) 0.75 40.0 $52.50
Mid Dosage (200 mg/day) 1.00 30.0 $70.00
High Dosage (300 mg/day) 1.50 20.0 $105.00

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Everyday Optimal CBD Oil Tincture (4000mg)

Everyday Optimal CBD Oil Tincture (4000mg)


CBD oil comes in many forms and potencies, but we haven’t seen any product sold by our competitors as powerful as our 4000mg cbd oil tincture. We make this powerful hemp oil product for people who demand fast, sure-fire relief from severe symptoms.

  • CBD Per Serving: 133.33mg
  • Number Of Servings: 30
  • Cost Per Serving: $9.67
  • Cost Per/mg of CBD: $0.07
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  • Fast Effective Relief
  • Zero THC
  • Made In USA
  Servings per day Days supplied in one package Cost per week
Low Dosage (150 mg/day) 1.13 26.7 $76.12
Mid Dosage (200 mg/day) 1.50 20.0 $101.50
High Dosage (300 mg/day) 2.25 13.3 $152.25

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Suggested CBD Dosage for ALS

Dosage Per Day


150 mg


200 mg


300 mg

The most common question asked by users is precisely how much CBD should be taken for a given condition. Unfortunately, the human body is extremely complex, and as such, everyone’s ideal medication may be slightly different. We suggest each person try a bit of experimentation to determine what a perfect dosage is for them.

That said, we can still provide a solid starting point for new users to start their journey. According to research, large doses of CBD between 200-300mg twice a day can significantly slow the onset and progression of ALS related symptoms, such as weakness, fasciculation, and atrophy.

That said, it’s still important to keep in mind that while CBD has become commonplace in much of the country, there are still plenty of places that treat CBD and THC as essentially the same thing. So you must remain prudent to always research before taking CBD while traveling.

We should also mention that while many CBD products are 100% THC-free and, therefore, will not get you high, some users find these CBD/THC blends provide even more potent benefits. As a result, it’s important to double-check any product if you are unwilling or unable to get high.

However you decide to take CBD, we sincerely hope you choose to leave your experience below for others to learn from. All it takes is a short description of your time taking CBD, and we can help others dealing with ALS. When it comes to something such as ALS, every moment is important, and anything you can do to improve the quality of life is paramount.

Tracking CBD Effectiveness For ALS

It can be difficult for people who just started taking CBD to get a feeling for whether or not it’s working. While it can be frustrating, it’s essential not to get discouraged too quickly. CBD is a relatively subtle medication, even when working correctly, and for many people, it will take a few days or weeks of regular treatment to start noticing any benefits. For conditions such as ALS, where the primary concern of caregivers and patients is comfort, CBD can really help ease issues after a couple of weeks.

One thing we suggest for everyone starting on CBD is to keep a journal of their dosages and subsequent symptoms. This is because the only real way to zero-in on your ideal dosage is to try different things and see what works best for your system. We firmly believe in the value this simple exercise provides newcomers to CBD, as it can really help make things more clear.

Some people feel a distinct difference from using CBD after just a couple days, while for others, it could take a few weeks of regular doses for your system to adjust. Everyone is different, and this is as true for our physiology as anything else.

One of the most common questions we ever get is asking if keeping a journal is really necessary. While it’s entirely possible to get everything you want out of CBD without keeping a journal, we firmly believe nothing else will make your transition more comfortable than this simple step.

Anyone who does decide to track their progress should strongly consider leaving their experience here for others to learn from. All that’s needed is a simple description of your time using CBD, along with how well it improved any anxiety, inflammation, and trouble sleeping. By working together and providing our experiences online, we can make things easier for the next person trying CBD for the first time.

Written By
John Mace Alois is lead content creator at the Did CBD Work? project. He’s analyzed over 400 research papers related to Cannabidiol and helped publish over 55 works related to different conditions for the project. He majored in Cultural Anthropology, with a minor in English, from the University at Albany. He is an avid collector of art supplies and refurbishes old furniture in his spare time.

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