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Alzheimer's overview

Alzheimer’s disease is a progressive brain disorder that causes brain cells to die over time. Over a slow progression, those with Alzheimer’s will experience a continual decline in their thinking, behavioral, and social skills. It can be hard to notice Alzheimer’s signs at first, as most common symptoms early on are things such as short-term memory loss, and even these don’t appear until several years in.

However, as the disease progresses, those suffering will develop severe memory loss, accompanied by an inability to carry out required daily activities. This decline in brain function only gets worse until complications from the disease result in death. The progressive memory loss associated with Alzheimer’s makes it a particularly heart-breaking disease to watch.

The primary symptom of Alzheimer’s disease is memory loss. It’s common for patients to notice this decline in their ability to recall recent events, but oftentimes it’s friends or family who first see a distinct change.

While minor memory loss is perfectly normal in healthy adults, there are a few vital signs to keep in mind if you’re worried about Alzheimer’s. These include the need for repeated statements one after another, getting lost in familiar places, or misplacing objects in illogical locations.

Other symptoms may include difficulty finding the correct name for everyday objects, or an inability to express thoughts and feelings. More advanced Alzheimer’s also leads to distinct behavioral changes, sometimes increasing mood swings, distrust in others, wandering, loss of inhibitions, or social withdrawal.

That said, Alzheimer’s patients will also generally retain certain skills for long into the cognitive decline. This can include things such as singing, dancing, crafting, telling stories, or even reading.

While much more research is needed to uncover precisely what causes Alzheimer’s, researchers have started to determine what plays a vital role. The current best hypothesis is that Alzheimer’s is caused by a combination of complex genetic, environmental, and lifestyle factors interacting over a long period.

While we may not know why it happens, research shows that the core issue in Alzheimer’s is a reduced ability of brain proteins to function properly. This, in turn, damages neurons, which disrupts brain function, and eventually leads to death. The loss of neurons spreads in a somewhat predictable pattern, and by the late stages of the disease, overall brain size has shrunk dramatically.

The most significant risk factor for Alzheimer’s is age, with the rate of developing Alzheimer’s increasing from two new diagnoses per 1000 at the age of 74, to 37 new diagnoses per 1000 for those 85 and older. Genetics also play an important but misunderstood role. Research shows the risk of developing Alzheimer’s is somewhat higher if an immediate family member had the disease, but most of how this relationship functions is still mysterious.

Other significant risk factors of developing Alzheimer’s include Down Syndrome, past head trauma, long-term difficulty sleeping, obesity, high blood pressure, or an aversion to social interaction. It’s worth noting that more women than men have Alzheimer’s, but researchers agree this is primarily because women, on average, live longer than men.

Alzheimer’s is the most common cause of dementia, with around 5.5 million people in the US alone affected by this disease. Broader estimates suggest about 44 million people around the world are currently living with this terrible condition.

Given the terminal diagnosis, it’s extremely important to focus on new and effective ways to increase comfort, while potentially slowing any disease progression. If you are worried that you or a loved one may be developing Alzheimer’s, don’t wait to contact your doctor. Only they can provide the most relevant information and action plan moving forward.

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Table of Contents

CBD Research For Alzheimer's

potencial impact research overview

Alzheimer's - The therapeutic potential of the endocannabinoid system for Alzheimer's disease

  • Neuroscience Research Australia
  • 2012

related conditions:

Alzheimers

This study looks at how expression of the endocannabinoid system affects Alzheimer's. What researchers found was that many of the effects of cannabinoids are beneficial to the treatment of Alzheimer's. This includes anti-inflammatory and neuroprotective properties, making CBD of particular interest.

Alzheimer's - Endocannabinoid signalling in Alzheimer's disease

  • Sheffield Institute for Translational Neuroscience
  • 2013

related conditions:

Alzheimers

Researchers look at the role endocannabinoids have in learning and memory, the two main symptoms of age-related dementia. The study reviews the potential of endocannabinoid manipulation to improve the progression of neurodegenerative diseases. While no treatments are known to reverse Alzheimer's related damage, there's clear evidence cannabinoid therapy may help reduce neuroinflammation, oxidative stress and neurodegeneration.

Alzheimer's - A Molecular Link Between the Active Component of Marijuana and Alzheimer's Disease Pathology

  • Scripps Research Institute
  • 2008

related conditions:

Alzheimers

This study focuses on the effect cannabinoids, such as CBD, can have on slowing the progression of neurodegenerative conditions. Researchers built a model of the chemical reaction between cannabinoids and enzymes that mark the beginning of Alzheimer's disease. In these models, cannabinoids were shown to be a far superior inhibitor, and it shows immense promise as a potential treatment.

Alzheimer's - Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells

  • University of Naples Federico II
  • 2004

related conditions:

Alzheimers

Researchers focused on the reaction between non-psychoactive cannabidiol (CBD) and specific peptides that appear in the brain alongside neurodegenerative disorders. These peptides were shown to inhibit neural pathways. They found that CBD lowered the number of peptides, offering protection to the neural pathways and slowing the progression of conditions such as Alzheimer’s.

Alzheimer's - The potential therapeutic effects of THC on Alzheimer's disease

  • University of South Florida
  • 2014

related conditions:

Alzheimers

For this study, researchers looked at a variety of ways in which cannabinoids are beneficial to those suffering from Alzheimer’s disease. They found that in low dosages, combinations of THC and CBD have the capability of lowering levels of peptides, protecting neural pathways, and enhancing mitochondrial functions. They ultimately found cannabinoids to be effective at slowing the progression of Alzheimer’s disease on multiple fronts.

Alzheimer's - The role of endocannabinoid signaling in the molecular mechanisms of neurodegeneration in Alzheimer's disease

  • University of Rome
  • 2015

related conditions:

Alzheimers

This review of the available information highlights multiple ways in which activation of the endocannabinoid system can benefit neurodegenerative disorders, via neuroprotection. Because there is no single known cause of the disease, researchers believe treatment ought to be effective across multiple avenues. Researchers found that this is one of the primary advantages of using cannabinoids, like CBD in treatment.

Alzheimer's - Cannabinoids for the treatment of dementia

  • Maudsley Hospital
  • 2009

related conditions:

Alzheimers

Looking at whether cannabinoids are effective for the treatment of dementia, researchers conducted two double-blind placebo studies. However, one study did not meet the criteria, and the other had insufficient data, so neither was able to provide scientifically relevant data. The researchers insist more studies are required to provide an answer to this very important potential use of CBD.

Alzheimer's - Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression

  • University of Rome
  • 2007

related conditions:

Alzheimers

Scientists studied mice to determine the effectiveness of cannabidiol on Abeta peptide production, one of the clear signs of Alzheimer’s Disease. Researchers found that with daily dosing of CBD, the Abeta peptide was reduced. They concluded that CBD may be a valuable tool in the treatment of dementia moving forward.

Alzheimer's - Cannabidiol: a promising drug for neurodegenerative disorders?

  • University of Naples Federico II
  • 2009

related conditions:

Alzheimers

This review seeks to determine how viable cannabinoids are as part of a treatment for Alzheimer's and other neurodegenerative disorders. CBD and THC have both been shown to provide distinct neuroprotective and anti-inflammatory benefits, making them of interest in Alzheimer's research. However, the non-psychoactive CBD is seen as the superior option to THC, which has impairing side-effects.

Alzheimer's - The role of the endocannabinoid system in Alzheimer's disease: facts and hypotheses

  • Institute of Biomolecular Chemistry
  • 2008

related conditions:

Alzheimers

This study takes a look at the endocannabinoid system’s role in the production of beta-amyloid-induced-tau protein, which the researchers believe may be a key cause of Alzheimer’s disease. They posit that CBD, a non-psychoactive substance, may help not only this protein production but several other symptoms and even causes of Alzheimer’s disease.

Alzheimer's - The role of phytochemicals in the treatment and prevention of dementia

  • Jodrell Laboratory
  • 2011

related conditions:

Alzheimers

This review of plant-derived phytochemicals identified several substances that may be beneficial in the treatment of neurodegenerative disorders. This list of derivatives includes ginseng, saffron, sage, and prominently cannabidiol. The researchers believe cannabinoids, such as CBD, may help delay the progression of dementia, although much more consistent data is required to prove this effect.

Alzheimer's - Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer's disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition

  • Johannes Gutenberg University Mainz
  • 2013

related conditions:

Alzheimers

Researchers bred mice with a specific cannabinoid receptor deficiency (CB1) to determine any potential impact on neurodegenerative disorders. However, most of the mice died before being adequately tested. Supplementation with CBD was found to lead to a lower amount of plaque, which is thought to impact Alzheimer’s. That said, they found no correlation between this specific deficiency and cognitive abilities within the mice.

Alzheimer's - Cannabidiol promotes amyloid precursor protein ubiquitination and reduction of beta amyloid expression in SHSY5YAPP+ cells through PPARγ involvement

  • University of Rome
  • 2014

related conditions:

Alzheimers

Researchers took a look at CBD’s capability to decrease beta-amyloid peptide, which is a distinct sign of Alzheimer’s disease. What they found was that CBD was successful in lowering the peptide’s production and promoted the survival of other full-length proteins. These results were all dependent on CBD’s relationship with the specific protein PPARy.

Alzheimer's - Cannabinoids for treatment of Alzheimer's disease: moving toward the clinic

  • Institut de Neuropatologia
  • 2014

related conditions:

Alzheimers

This review states all of the benefits that cannabinoids, especially non-psychoactive CBD, can have for Alzheimer’s Disease. Along with the decrease of beta-amyloid peptides, CBD has been shown to promote the brain’s ability to repair itself as well as offering protection to neuro-pathways and a reduction in neuroinflammation.

Alzheimer's - Can Marijuana Prevent Alzheimer’s?

  • Robyn Griggs Lawrence
  • 2012

related conditions:

Alzheimers

In this article, the author speaks about the possibility of cannabinoids as a potential treatment for Alzheimer’s disease. Multiple studies are reviewed for their support of cannabinoids. The author also discusses the possibility for public backlash on the idea of a marijuana derivative used in such treatments, along with the negative aspects of potential abuse for the psychoactive derivatives of cannabis.

CBD Research That Might Be Useful for Symptoms of Alzheimer's

potencial impact research overview

Anxiety - Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence

  • University of Melbourne, Australia
  • 2013

related conditions:

Anxiety

A comprehensive review of all the plant-based medicine which has had both preclinical and human clinical trials conducted about their anxiolytic-like effect. An analysis of over 1500 papers identified 21 plants which had been adequately tested, with one of the most successful of these plants found to be CBD enriched Cannabis species.

Inflammation - Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice

  • Tongji University School of Medicine
  • 2013

related conditions:

Inflammation

A study of mice concluded CBD has significant anti-inflammatory effects. The researchers also saw evidence that the expression of the GPR55 receptor was improved after starting on CBD. Treatment with CBD was shown to significantly decrease the levels of several inflammation-related chemicals in test subjects.

Parkinson's- Cannabinoids control spasticity and tremor in a multiple sclerosis model

  • University College London
  • 2000

related conditions:

Restlessness

Their testing confirmed CBD was able to effectively reduce the strength and frequency of tremors and spasticity in test mice. They concluded that interaction with the CB1 and CB2 receptors is the primary culprit of this effect.

Alzheimer's & CBD Research Overview

It hasn't taken CBD very long to go from a barely known alternative medicine to the hottest new trend in natural remedies. The majority of this hype is thanks to the wide range of conditions which CBD has been proven to benefit in one way or another. There is even some emerging evidence that CBD and other cannabinoids may help slow the progression of Alzheimer's Disease.

Many of these reports have focused on the anti-inflammatory and neuroprotective benefits of CBD as a potential avenue for treatment. For example, The therapeutic potential of the endocannabinoid system for Alzheimer's disease was able to determine several properties of CBD, which directly impact the treatment of dementia, such as Alzheimer's.

Another report, called Endocannabinoid signalling in Alzheimer's disease, looked into how CBD and other cannabinoids affect memory and learning in Alzheimer's patients. Although no known treatment can reverse the damage, CBD was shown to reduce neuroinflammation, neurodegeneration, and even oxidative stress on the system.

Some researchers believe any effective treatment for complex neurodegenerative disorders needs to have an impact across many parts of your system. As such, CBD offers an exciting option for doctors treating Alzheimer's. Research such as The role of endocannabinoid signaling in the molecular mechanisms of neurodegeneration in Alzheimer's disease has proven CBD provides this broad impact sought after.

Reviews of the available information, such as Cannabidiol: a promising drug for neurodegenerative disorders?, suggest both CBD and THC are viable options for neuroprotection via a reduction in inflammation. However, CBD is seen as the superior treatment for Alzheimer's due to its higher tolerability.

Other reviews, such as The role of phytochemicals in the treatment and prevention of dementia, indicate CBD may even help in slowing the progression of neurodegenerative disorders like Alzheimer's. Their review of plant-based medications provided some interesting foundation for further inquiry.

While more research is needed into the direct impact of CBD on dementia-related inflammation, we have a ton of reliable reports which prove the anti-inflammatory benefits of CBD. This includes Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice, which showed expression of the GPR55 receptor was especially useful in lowering inflammation.

Further reports have started to determine alternative ways in which CBD is helping slow the progression of Alzheimer's. One of the most promising theories involves the impact of cannabinoids on peptides in the brain. For example, Neuroprotective effect of cannabidiol, a non-psychoactive component from Cannabis sativa, on beta-amyloid-induced toxicity in PC12 cells, showed a distinct relationship between CBD and these peptides. The peptides were shown to inhibit neural pathways, but an introduction of CBD significantly reduced the overall level of peptides present.

Some reports have shown an interaction between CBD and THC provides a particularly powerful effect. For instance, The potential therapeutic effects of THC on Alzheimer's disease indicated, these combinations could effectively lower levels of peptides while also improving mitochondrial function. Their results once again provide evidence that CBD is effective at slowing the progression of Alzheimer's by working at several different levels in the body.

Teams have looked into precisely why CBD seems to provide this benefit. Cannabidiol in vivo blunts beta-amyloid induced neuroinflammation by suppressing IL-1beta and iNOS expression studied the usefulness of CBD to treat Abeta peptides in mice models. The team found that daily doses of CBD could dramatically lower the rate of peptide production. Further research is needed, but this impact could have a massive impact on dementia treatments moving forward.

The role of the endocannabinoid system in Alzheimer's disease: facts and hypotheses, looked into how cannabinoids impact the production of other important chemicals, including beta-amyloid-induced-tau proteins, which many researchers believe has a direct relation to developing Alzheimer's. More data must be collected, but the team showed optimism about the distinct benefits of CBD to treat the causes of the disease.

Other teams have also looked into beta-amyloid production, including Cannabidiol promotes amyloid precursor protein ubiquitination and reduction of beta amyloid expression in SHSY5YAPP+ cells through PPARγ involvement. That team not only showed CBD reduced peptide production, but it also increased the survivability of essential proteins.

Larger reviews of the data have also provided similar results. Cannabinoids for treatment of Alzheimer's disease: moving toward the clinic, reviewed the impact of CBD on the progression of Alzheimer's. They showed clear evidence that not only is beta-amyloid peptide production significantly reduced, but CBD was also shown to greatly promote the brain's ability to protect itself by reducing inflammation.

Further analysis has attempted to uncover any other benefits of CBD for Alzheimer's patients, but not all have provided the same results. One review, called Can Marijuana Prevent Alzheimer's?, analyzed the benefits of CBD to treat dementia and other neurodegenerative disorders. While noting some significant changes induced by CBD, they also worried about the cultural impact of a cannabis-derived treatment.

Despite these concerns, other research, like A Molecular Link Between the Active Component of Marijuana and Alzheimer's Disease Pathology, highlights the ability of CBD to slow dementia by reducing overall oxidative stress and neuroinflammation.

Still, other teams were unable to find sufficient evidence to show a statistical correlation between CBD and Alzheimer's. This includes reports like Cannabinoids for the treatment of dementia, and Cannabinoid receptor 1 deficiency in a mouse model of Alzheimer's disease leads to enhanced cognitive impairment despite of a reduction in amyloid deposition. It's worth noting that despite their lack of success, both teams remained enthusiastic about research into the ability of CBD to treat Alzheimer's.

This is partially because of other, well-documented uses of CBD. Studies such as Cannabinoids control spasticity and tremor in a multiple sclerosis model, and Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence have provided plenty of evidence to suggest cannabidiol can, at the very least, provide relief from some of the symptoms which often accompany Alzheimer's like anxiety and spasticity.

Best CBD for Alzheimer's

Diamond CBD Full Spectrum Honey Tincture (2500mg)

Diamond CBD Full Spectrum Honey Tincture (2500mg)

description

These tasty new honey tinctures are made of 100% all-natural honey, presenting a delicious addition to how to deliver you with the ideal amount of CBD. Available in strengths ranging from 25mg to 3500mg, add it to your morning coffee, tea, or just use it throughout the day to sweeten up every moment while enjoying all of the awesome benefits that CBD offers.

$128.00
  • CBD Per Serving: 83.33mg
  • Number Of Servings: 30
  • Cost Per Serving: $4.27
  • Cost Per/mg of CBD: $0.05
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advantages

  • Honey Flavor
  • Control Over Dosing
  • All Natural Ingredients
  Servings per day Days supplied in one package Cost per week
Low Dosage (500 mg/day) 6.00 5.0 $179.21
Mid Dosage (1000 mg/day) 12.00 2.5 $358.41
High Dosage (1500 mg/day) 18.00 1.7 $537.62

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Relax Full Spectrum CBD Oil (3500mg)

Relax Full Spectrum CBD Oil (3500mg)

description

Relax Full Spectrum CBD Oil, available with an oil tincture dropper, delivers the ideal amount of CBD to meet all of your wellness needs. Made in the USA  from 100% high quality industrial hemp, this 3500 mg bottle of CBD is perfect for those wanting to combat stress, anxiety, and chronic pain.

$168.00
  • CBD Per Serving: 116.67mg
  • Number Of Servings: 30
  • Cost Per Serving: $5.60
  • Cost Per/mg of CBD: $0.05
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advantages

  • 100% Hemp Product
  • Made in USA
  • Full Spectrum
  Servings per day Days supplied in one package Cost per week
Low Dosage (500 mg/day) 4.29 7.0 $168.00
Mid Dosage (1000 mg/day) 8.57 3.5 $335.99
High Dosage (1500 mg/day) 12.86 2.3 $503.99

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Everyday Optimal CBD Oil Tincture (4000mg)

Everyday Optimal CBD Oil Tincture (4000mg)

description

CBD oil comes in many forms and potencies, but we haven’t seen any product sold by our competitors as powerful as our 4000mg cbd oil tincture. We make this powerful hemp oil product for people who demand fast, sure-fire relief from severe symptoms.

$289.99
  • CBD Per Serving: 133.33mg
  • Number Of Servings: 30
  • Cost Per Serving: $9.67
  • Cost Per/mg of CBD: $0.07
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advantages

  • Fast Effective Relief
  • Zero THC
  • Made In USA
  Servings per day Days supplied in one package Cost per week
Low Dosage (500 mg/day) 3.75 8.0 $253.75
Mid Dosage (1000 mg/day) 7.50 4.0 $507.50
High Dosage (1500 mg/day) 11.25 2.7 $761.24

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Suggested CBD Dosage for Alzheimer's

Dosage Per Day

Low

500 mg

Mid

1000 mg

High

1500 mg

By far, the most common question we get is how much CBD is required to treat a given condition. While it would be fantastic if we had a simple answer to offer everyone, the truth is that people are complex, and everyone may require a slightly different regimen.

That said, we can still provide a solid starting point for new users to start their journey with. According to research, large amounts of CBD are needed to provide these neuroprotective benefits. In fact, evidence shows about 5mg of CBD per pound per day is how much people looking to protect from Alzheimer’s should look to take, meaning around 1000mg per day for most people.

It’s also important to remember that while CBD is perfectly legal in most places, federal laws, and local laws in some places may still treat CBD and THC as basically the same. As such, be sure to take extra care before taking any cannabidiol with you on your travels.

We should also mention that not all CBD products are 100% THC free. In fact, many still contain THC as a way to improve overall effectiveness. This just means anyone who’s unwilling or unable to get high needs to double-check and make sure they only buy 100% CBD products.

However you decide to take your CBD, we really hope you choose to track your progress and leave that experience here for others to learn from.

All it takes is a little information to help people feel like they’re making the right choice. Together we can make the world a much more well-informed place and hopefully reduce people’s suffering wherever possible.

Tracking CBD Effectiveness For Alzheimer's

Regardless of why you or a loved one is taking CBD, it can be challenging to understand how it's really working at first. This often frustrating part of the process can deter a lot of people from continuing dosages. However, if you give your body time to adjust, it can significantly increase the chances CBD works for you. When it comes to conditions such as Alzheimer's, the primary concerns should be patient comfort and slowing progression, if possible.

Something we suggest to anyone starting on CBD is keeping a small journal for the first few weeks. All it takes is a log of your daily dose and the subsequent symptoms, and you'll be amazed at how much insight it can actually provide. Finding the right dose requires good old fashioned experimentation, and tools like this can make your job much easier.

As we mentioned, some people will notice a change almost immediately. While for others, it could take a few weeks, if it even impacts them at all. Everyone is different, and what works for some people, simply may not work for others.

People ask if keeping the journal is really necessary, and quite frankly, it isn't. That said, nothing else you can do with such ease will improve the value CBD provides faster. We've seen a lot of people try a lot of ways, and in this case, simple is better.

If you or a loved one does decide to track progress using CBD, we genuinely hope you choose to leave the experience here for others to learn from. All it takes is a short description of how CBD worked, along with a score for how well it improved any related symptoms. Everyone is looking for the same answers with such a new treatment option, and working together is the key to unlocking the mystery.

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