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Anxiety overview

Anxiety is a perfectly normal, and even healthy emotion. That said, for millions of people suffering from an anxiety disorder, this emotion stops being useful and becomes debilitating. In fact, around 40 million people suffer from an anxiety disorder in America alone. Even worse, statistics show that only approximately 36% of people are actively receiving treatment. Symptoms can manifest in a myriad of ways, but they’re all mostly related to how we process and regulate our thoughts and emotions. Milder forms of anxiety can result in feelings of general uneasiness, while severe anxiety can manifest with debilitating physical symptoms which last for hours or even days. Two of the most common forms of an anxiety disorder include generalized anxiety disorder (GAD) and panic disorder.

GAD is characterized by excessive and prolonged concern over general life events and situations. It’s by far the most common type of anxiety disorder and can be quite tricky to deal with since people often cannot pinpoint the source of their anxiety. Alternatively, panic disorders are typically characterized by sudden bouts of overwhelming anxiety and fear. These more intense bursts often lead to shaking, dizziness, nausea, confusion, and even difficulty breathing. While most peak after about 10 minutes, severe attacks are known to last for hours. These are far from the only two forms of anxiety, with many others such as specific phobias, selective mutism, and social anxiety disorder, also having a significant impact. Regardless of what type of anxiety disorder you or a loved one is dealing with, effective treatment options often make a massive difference in the quality of life.

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Table of Contents

CBD Research For Anxiety

potencial impact research overview

Anxiety - Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug

  • Institute of Psychiatry, Universidade Federal do Rio de Janeiro, Brazil
  • 2012

related conditions:

Anxiety

After using both animal models and human volunteers, the researchers clearly showed CBD has an “anxiolytic-like” effect. They showed the introduction of CBD significantly increased serotonin, norepinephrine, and dopamine production. Increased production of these neurotransmitters has been shown to improve mood and the ability to regulate emotion drastically.

Anxiety - Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa

  • Institute of Psychiatry - Federal University of Rio de Janeiro, Brazil
  • 2014

related conditions:

Anxiety

Researchers tested the impact of CBD on animal models in several stress-inducing experiments, including the forced swim test and elevated plus maze. The introduction of CBD was shown to improve stress by interacting with the 5-HT1A neuro-receptor. The researchers credit this interaction for the “anxiolytic-like and antidepressant-like” effect of CBD.

Anxiety - Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients

  • University of São Paulo, Brazil
  • 2011

related conditions:

Anxiety

Double-blind, randomized testing concluded pretreatment with CBD dramatically improve mood while reducing cognitive impairment and discomfort during simulated public speaking tests (SPST). Researchers also noted the test subject’s anticipatory speech was significantly decreased after taking CBD. Impressively, the team observed that starting on a CBD regimen brought test subjects in line with the control groups.

Anxiety - Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report

  • University of São Paulo, Brazil
  • 2010

related conditions:

Anxiety

The report provides an in-depth look at the underlying brain mechanisms behind the value CBD. Researchers concluded that relative to the placebo, an oral dose of CBD (400mg) significantly reduced ECD uptake in the left parahippocampal gyrus, hippocampus, and inferior temporal gyrus. These findings correlate with a dramatic improvement in overall mood and mental well-being.

Anxiety - Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation

  • Vanderbilt University Medical Center, Nashville, USA
  • 2014

related conditions:

Anxiety

Anxiety - Effects of cannabidiol (CBD) on regional cerebral blood flow

  • University of São Paulo, São Paulo, Brazil
  • 2014

related conditions:

Anxiety

CBD significantly improves mood and increases mental sedation, allowing for a sense of calm. They traced this effect to two parts of the brain which significantly decreased ECD uptake with CBD relative to the placebo. Tests show CBD has important anxiolytic properties via the limbic and paralimbic systems.

Anxiety - The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1A receptors

  • University of São Paulo, São Paulo, Brazil.
  • 2011

related conditions:

Anxiety

Systemic CBD treatments were shown to have significant anxiolytic-like effects in male Wistar lab rats. CBD treatment increased open arms exploration during the elevated plus-maze, as well as the number of punished licks in the Vogel conflict test. Importantly, pretreatment with a 5-HT1A receptor antagonist blocked the positive effects.

Anxiety - The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system.

  • University of Sao Paulo, Sao Paulo, Brazil.
  • 2013

related conditions:

Anxiety

CBD promotes cell proliferation and cell cycle progression of not only CB1 and CB2 cannabinoid receptors, but also hippocampal cells. This is believed to be a significant part of the reason why CBD has such powerful anxiolytic effect. CB1-selective antagonist AM251 was also shown to block the effect of CBD.

Anxiety - Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence

  • University of Melbourne, Australia
  • 2013

related conditions:

Anxiety

A comprehensive review of all the plant-based medicine which has had both preclinical and human clinical trials conducted about their anxiolytic-like effect. An analysis of over 1500 papers identified 21 plants which had been adequately tested, with one of the most successful of these plants found to be CBD enriched Cannabis species.

CBD Research That Might Be Useful for Symptoms of Anxiety

potencial impact research overview

Mood - Sub-chronic impact of cannabinoids in street cannabis on cognition, psychotic-like symptoms and psychological well-being

  • University College London, UK
  • 2012

related conditions:

Mood Disorders

A much lower rate of psychosis-like symptoms were found in those who used marijuana with contained both THC and CBD, compared with types high only in THC. Researchers conclude the CBD attenuates the psychotic-like effects, leading to a greater sense of well-being and an overall improved mood.

Sleep - Cannabis, Cannabinoids, and Sleep: a Review of the Literature

  • Palo Alto University, CA, USA
  • 2017

related conditions:

Sleep

This report concludes CBD holds promise for significantly increasing the quality of REM sleep. Researchers believe it could one day be a primary force behind improved overall sleep quality. CBD was even shown to reduce daytime sleepiness in many patients.

Nausea - Interaction between non-psychotropic cannabinoids in marijuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews

  • Palo Alto University, CA, USA
  • 2017

related conditions:

Nausea

CBD was shown to significantly suppress vomiting in lab rats and shrews. Researchers used another substance, known as cannabigerol (CBG) to reverse this suppression. Moderate doses of CBG and CBD are opposing each other at the 5-HT1A receptor, which is known to play an essential role in regulating nausea.

Anxiety & CBD Research Overview

There’s a movement growing around the amazing benefits of CBD to treat various debilitating conditions, including most types of anxiety. Especially with the popularity of alternative treatments over prescription drugs, CBD is quickly gaining a loyal following of users who suffer from anxiety disorders. A comprehensive review of plant-based medicine, called Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence, gathered all the available data on 21 different plant-based medications, including the particularly effective CBD enriched species of cannabis. Thanks to hard work by researchers like these, we now have a solid understanding of not only what kinds of anxiety CBD treats, but also how it gets the job done. Let’s take a brief overview of all the most important studies you should know.

One of the main symptoms of anxiety problems is an uncontrollable sense of dread or restlessness. As such, anything which can significantly improve mood or mental well-being is a reliable treatment option. We have several reports which clearly indicate CBD is quite adept at calming and enhancing mood. For instance, a report called Cannabidiol, a Cannabis sativa constituent, as an anxiolytic drug, used both animal and human models to show CBD has an “anxiolytic-like” effect via increasing neurotransmitter production, such as serotonin and dopamine. Other reports, such as Neural basis of anxiolytic effects of cannabidiol (CBD) in generalized social anxiety disorder: a preliminary report, and Effects of cannabidiol (CBD) on regional cerebral blood flow, may hold the key as to why this happens. CBD was shown to significantly decrease the ECD uptake the left parahippocampal gyrus, hippocampus, and inferior temporal gyrus, meanwhile, tests show the limbic and paralimbic systems play a critical role in regulating the effect of CBD on mood.

Regardless of what type of anxiety you’re dealing with, it seems that CBD could be doing more than just binding to the CB1 and CB2 receptors in your brain. In fact, a report called The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system concluded that CBD is also interacting with hippocampal cells, which they believe is a significant part of why CBD has such a potent anti-anxiety effect. A report called Sub-chronic impact of cannabinoids in street cannabis on cognition, psychotic-like symptoms and psychological well-being showed that CBD plays a vital role in regulating any potential adverse effects of marijuana when compared with types high in THC but have little to no CBD. Finally, insomnia is another common problem affecting the overall mental well-being of people dealing with anxiety. Luckily a study called Cannabis, Cannabinoids, and Sleep: a Review of the Literature proves that CBD could be the key to dramatically increasing sleep quality as well as reducing daytime sleepiness.

 

Another primary symptom for most people dealing with anxiety disorders is a significantly increased level of stress. Most research these days credits the anxiolytic-like effect of CBD to interaction with neuro-receptors. One such study is called Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa, which noted CBD improved stress-related issues during standardized stress tests on lab rats. They believe it’s interaction with the 5-HT1A neuro-receptor which helps facilitate this sense of calm. We also have double-blind, randomized testing which concluded CBD is an effective way to relieve stress brought on by public speaking, even in those who suffer from a form of social phobia. The report, called Cannabidiol reduces the anxiety induced by simulated public speaking in treatment-naïve social phobia patients, ultimately found the correct CBD regimen brings stress-related anxiety, induced by public speaking, into line with control groups; a massive improvement. Other reports have made similar conclusions about the effect of CBD on various forms of anxiety. A study called Central anandamide deficiency predicts stress-induced anxiety: behavioral reversal through endocannabinoid augmentation noted the transient anxiety related to acute foot-shock stress, which can often last over 24 hours unchecked, was quickly relieved once CBD was started.

Several other studies about the relationship between CBD and anxiety are only starting to be explored, but nonetheless, provide some fascinating insight into the possibilities of CBD. A report called The anxiolytic-like effects of cannabidiol injected into the bed nucleus of the stria terminalis are mediated by 5-HT1A receptors, showed some of the strongest evidence to date that systemic CBD treatments significantly reduce fear and anxiety in lab rats. It also provides a deeper understanding of what causes this effect, as pretreatment of the 5-HT1A receptor effectively blocked any positive impact of CBD. This goes hand in hand with another report called, Interaction between non-psychotropic cannabinoids in marijuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews. The team also observed this role of the 5-HT1A receptor, but actually took things a step further to determine cannabigerol (CBG) was the primary antagonist of CBD. Their findings also suggest CBD could be an effective treatment for stress-related vomiting, which is another common symptom of most anxiety disorders.

Best CBD for Anxiety

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Everyday Optimal CBD Capsules (200mg)

description

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$299.99
  • CBD Per Serving: 200mg
  • Number Of Servings: 30
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  • Cost Per/mg of CBD: $0.05
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  • 100% USA Made
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  Servings per day Days supplied in one package Cost per week
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NoteCBD Tincture (250mg)

NoteCBD Tincture (250mg)

description

Support your health and wellness with CBD-infused tinctures specifically formulated for human consumption. This tincture is made with full spectrum hemp oil, MCT oil, and essential oils.

$45.00
  • CBD Per Serving: 8.33mg
  • Number Of Servings: 30
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  • Cost Per/mg of CBD: $0.18
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  • Full Spectrum Extract
  • Lab Certified
  • Made In USA
  Servings per day Days supplied in one package Cost per week
Low Dosage (40 mg/day) 4.80 6.2 $50.42
Mid Dosage (300 mg/day) 36.01 0.8 $378.15
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Everyday Optimal CBD Oil Tincture (4000mg)

Everyday Optimal CBD Oil Tincture (4000mg)

description

CBD oil comes in many forms and potencies, but we haven’t seen any product sold by our competitors as powerful as our 4000mg cbd oil tincture. We make this powerful hemp oil product for people who demand fast, sure-fire relief from severe symptoms.

$289.99
  • CBD Per Serving: 133.33mg
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  • Cost Per/mg of CBD: $0.07
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  • Made In USA
  Servings per day Days supplied in one package Cost per week
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Mid Dosage (300 mg/day) 2.25 13.3 $152.25
High Dosage (600 mg/day) 4.50 6.7 $304.50

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Suggested CBD Dosage for Anxiety

Dosage Per Day

Low

40 mg

Mid

300 mg

High

600 mg

We are often asked what the precise correct dosage of CBD is for various conditions. The truth is it’s a much more complicated answer than most people would think. The most significant factor in dosage is always going to be you personally. Differences in age, sex, weight, and height all have an impact on how much is the ideal amount. But even two people who are seemingly the same will likely find two different dosages suit them best.

Experimentation is just part of the process. Luckily CBD is non-psychoactive, so there’s minimal risk in trying various strengths until you hit the sweet spot. That said, most researchers recommend anywhere between 40mg and 600mg daily, with higher dosages best for epilepsy cases, and mid-sized doses for anxiety relief.

As with any condition, it’s always best if you start out taking your CBD at night as well as avoiding edibles until you’ve got a good feeling for your ideal range and how it’s going to affect you. If all else fails, it’s also believed small amounts of THC in CBD oils help facilitate the benefits. However, if you go this route always take care as THC is psychoactive and too much will get you high.

Tracking CBD Effectiveness For Anxiety

It can be challenging to track your progress with CBD if you don’t know what to look out for. As mentioned, the category of anxiety disorders covers a wide range of specific conditions. But most of these differences are related to triggers more than symptoms or treatment options.

As such, one of the primary ways you can tell if CBD is working for you is by paying attention to your general anxiety level and mood throughout the day and compare that with your norms. This is especially true for people who struggle with specific phobias or social anxiety; just being aware of how you’re reacting in those situations is always the best way to track effectiveness.

Another primary symptom of anxiety is stress, so keeping tabs on what’s stressing you out and how it compares with normal is still the best way to understand the impact. Regardless of what type of anxiety disorder you or a loved one is dealing with, CBD could be a real answer to improving quality of life.

Be sure to leave us your personal experiences using CBD to treat anxiety. If you really want to help others out, be sure to leave a specific grade for the mood elevation, stress reduction, and improvement in restlessness provided by CBD. If we work together, everyone will have access to the information they need to improve their quality of life.

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