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Atherosclerosis overview

Published on December 13th, 2019

Last updated on December 30th, 2019

Atherosclerosis occurs when there’s a buildup of fats and cholesterol on artery walls. This buildup, also known as plaque, can severely restrict blood flow and lead to several serious conditions, including heart attack and stroke.

Atherosclerosis actually a specific type of Arteriosclerosis, or hardening of the oxygen carrying blood vessels, which can restrict adequate blood flow. However, these terms are sometimes used interchangeably. While Atherosclerosis is often considered a heart condition, it affects arteries throughout the body

Atherosclerosis develops gradually over time, with mild Atherosclerosis lacking any clear warning signs or symptoms. By the time most people notice anything, their arteries have already stiffened and narrowed enough to restrict blood flow. In fact, in rare cases the first real symptom is a heart attack or stroke, which occurs when the blockage breaks apart.

That said, the typical symptoms of moderate to severe Atherosclerosis can vary significantly depending on which part of the body is affected most. For example, atherosclerosis in the heart arteries can cause chest pain and pressure, while atherosclerosis in the arms or legs will generally experience pain when walking.

Another common type of atherosclerosis is in the arteries leading to the brain. This can cause several notable symptoms, including sudden numbness or weakness in limbs, difficulty speaking, temporary loss of vision, or drooping face muscles. It’s important to stay aware of your body to prevent these issues from ballooning into much larger problems.

Atherosclerosis is a very slow and progressive disorder. As such, some research suggests it can even start to develop as early as childhood in some people. The precise causes of this buildup aren’t currently known, but most researchers believe damage in the inner layer of the artery walls may lead to atherosclerosis.

This initial damage could be caused by a number of different things, including high blood pressure or cholesterol, smoking, obesity, and even simple inflammation. Once this damage occurs however, things can become clumped together and start to build a blockage.

Over time, the blockage which is made of mostly cholesterol, can build up and begin to harden reducing overall blood flow. As mentioned, the danger is not just when arteries become fully blocked. The plaque buildup can also break off or cause a blood clot, both of which can cause a severe heart attack or stroke.

The most obvious risk factor of atherosclerosis is aging, as this inevitably leads to hardening of the artery walls. Outside of this, things like high blood pressure or cholesterol, obesity, smoking, family history, and lack of proper diet and exercise, can all directly lead to severe atherosclerosis.

Atherosclerosis is often considered a type of heart disease since it affects arteries, regardless of where in the body. Heart disease at large is the leading cause of death among both men and women, with atherosclerosis being a factor in most conditions. In fact, an estimated 90,000,000 people around the country live with a cardiovascular condition such as atherosclerosis.

If you are worried that you or a loved one may be dealing with moderate to severe atherosclerosis, be sure to contact your doctor as soon as possible. Only they can provide an accurate diagnosis and treatment plan moving forward.

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Table of Contents

CBD Research For Atherosclerosis

potencial impact research overview

Atherosclerosis - The role of the endocannabinoid system in atherosclerosis

  • University Hospital
  • 2008

related conditions:

Atherosclerosis

In this study, researchers looked at the ways in which the endocannabinoid system affects atherosclerosis. Researchers looked at blocking CB1 receptors as well as activating CB2 receptors with cannabinoids. Blocking CB1 receptors with CBD showed some slight changes in humans and rodents, showing promise. However, the exact role and extent of the endocannabinoid system in atherosclerosis requires more study.

Atherosclerosis - Cannabinoid receptors in atherosclerosis

  • University Hospital
  • 2006

related conditions:

Atherosclerosis

This review looks at the potential for cannabinoids as a treatment for heart conditions. Cannabinoids were proven to affect the progression of atherosclerosis as well as other inflammatory conditions, indicating cannabinoids have the potential to work as a therapy for the disease. The authors express that cannabinoid treatment without the psychotropic effects of THC would be especially beneficial.

Atherosclerosis - The potential use of cannabidiol in the therapy of metabolic syndrome

  • Semmelweis Egyetem
  • 2012

related conditions:

Atherosclerosis

Here researchers take a look at how CBD affects the metabolic systems. They found it can decrease excessive appetite. It also affects fat storage and the ability to fight oxygen loss in parts of the body. CBD was shown to moderate glucose levels, which is effective in fighting atherosclerosis. Researchers suggest cannabidiol as a supplementary therapy for a variety of diseases and conditions.

Atherosclerosis - Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice

  • Nature
  • 2005

related conditions:

Atherosclerosis

This study looks at a low oral dose of cannabinoids as a treatment for atherosclerosis in mice. They found that this treatment resulted in significant inhibition of the disease. Many of the factors of the disease were able to be treated, including inflammation, a decrease in interferon-y secretion, and macrophage chemotaxis. Overall, treatment of atherosclerosis with CBD was deemed extremely valuable.

CBD Research That Might Be Useful for Symptoms of Atherosclerosis

potencial impact research overview

Mood - Sub-chronic impact of cannabinoids in street cannabis on cognition, psychotic-like symptoms and psychological well-being

  • University College London, UK
  • 2012

related conditions:

Mood Disorders

A much lower rate of psychosis-like symptoms were found in those who used marijuana with contained both THC and CBD, compared with types high only in THC. Researchers conclude the CBD attenuates the psychotic-like effects, leading to a greater sense of well-being and an overall improved mood.

Inflammation - Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice

  • Tongji University School of Medicine
  • 2013

related conditions:

Inflammation

A study of mice concluded CBD has significant anti-inflammatory effects. The researchers also saw evidence that the expression of the GPR55 receptor was improved after starting on CBD. Treatment with CBD was shown to significantly decrease the levels of several inflammation-related chemicals in test subjects.

Asthma - The role of cannabinoids in inflammatory modulation of allergic respiratory disorders, inflammatory pain and ischemic stroke

  • University of Florence
  • 2012

related conditions:

Asthma

The team wanted to understand how cannabinoids affect inflammation, especially regarding allergic reactions. They found activation of the CB1 receptors was associated with a bronchodilator effect or widening of the throat. The team also concluded activation of the CB2 receptor with CBD has an overall anti-inflammatory impact, particularly by decreasing the amount of pro-inflammatory mediators present in the system.

Atherosclerosis & CBD Research Overview

It hasn’t taken very long for CBD to grow into its own from a little-known natural medication. CBD is now seen for what it is, an exciting alternative treatment option for many kinds of conditions. Researchers are constantly publishing new reports refining everything we understand about cannabidiol. This has produced some interesting discoveries about the ability of CBD to help prevent, or at the very least, reduce symptoms of moderate to severe atherosclerosis.

This includes reports such as The role of the endocannabinoid system in atherosclerosis, which tested the impact of endocannabinoids on atherosclerosis. Researchers examined the effect of blocking and activating various endocannabinoid receptors throughout the system. They concluded that more research is needed, but the early results are quite promising.

A different report out of the University Hospital in Geneva, Switzerland called Cannabinoid receptors in atherosclerosis, found evidence CBD treats several key risk factors of severe atherosclerosis. This team was especially encouraged by CBD over THC, thanks to the lack of psychoactive effects, and higher tolerability in general.

Other teams have looked into how metabolic systems interact with CBD and the development of conditions such as atherosclerosis. For instance, The potential use of cannabidiol in the therapy of metabolic syndrome, showed CBD could not only reduce appetite, but it can impact fat storage and reduce oxygen loss. All of these factors show a distinct value of CBD as a supplementary treatment of atherosclerosis.

Even more impressively, Low dose oral cannabinoid therapy reduces progression of atherosclerosis in mice, showed CBD could provide significant inhibition of atherosclerosis. They identified several key factors, including inflammation, a decrease in interferon-y secretion, and macrophage chemotaxis, as primary reasons behind this benefit.

Other research we have on CBD, not explicitly related to atherosclerosis, also paints a very positive picture of the outlook. Studies such as Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice and many others have shown CBD is a powerful anti-inflammatory medication thanks to the GPR55 receptor in particular.

Pain relief is another commonly referenced benefit of CBD, as shown by reports such as Control of pain initiation by endogenous cannabinoids. The team proved an interaction between two distinct substances in CBD is exponentially increasing the pain-relieving effects.

CBD has even been shown to benefit some of the common symptoms of moderate atherosclerosis, including shortness of breath. In fact, The role of cannabinoids in inflammatory modulation of allergic respiratory disorders, inflammatory pain and ischemic stroke, proved cannabidiol is able to widen the throat, significantly improving overall airflow. This could one day help reduce breathlessness associated with a wide range of conditions.

Best CBD for Atherosclerosis

NoteCBD Capsules (10mg)

NoteCBD Capsules (10mg)

description

Enjoy the benefits of hemp extract with the convenience of a capsule. Each capsule contains a pre-portioned dose of full-spectrum hemp extract and MCT oil.

$45.00
  • CBD Per Serving: 10mg
  • Number Of Servings: 30
  • Cost Per Serving: $1.50
  • Cost Per/mg of CBD: $0.15
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advantages

  • Full Spectrum
  • Lab Certified
  • Organic
  Servings per day Days supplied in one package Cost per week
Low Dosage (15 mg/day) 1.50 20.0 $15.75
Mid Dosage (45 mg/day) 4.50 6.7 $47.25
High Dosage (90 mg/day) 9.00 3.3 $94.50

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Pure CBD Oil Capsules, (50mg)

Pure CBD Oil Capsules, (50mg)

description

Every Day Optimal Soft Gel PCR Hemp Oil Capsule contains 50mg of pure CBD.

$119.99
  • CBD Per Serving: 50mg
  • Number Of Servings: 30
  • Cost Per Serving: $4.00
  • Cost Per/mg of CBD: $0.08
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advantages

  • Easy Capsule Form
  • All Natural
  • GMP Compliant
  Servings per day Days supplied in one package Cost per week
Low Dosage (15 mg/day) 0.30 100.0 $8.40
Mid Dosage (45 mg/day) 0.90 33.3 $25.20
High Dosage (90 mg/day) 1.80 16.7 $50.40

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NoteCBD Capsules (25mg)

NoteCBD Capsules (25mg)

description

Enjoy the benefits of hemp extract with the convenience of a capsule. Each capsule contains a pre-portioned dose of full-spectrum hemp extract and MCT oil.

$95.00
  • CBD Per Serving: 25mg
  • Number Of Servings: 30
  • Cost Per Serving: $3.17
  • Cost Per/mg of CBD: $0.13
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  • Full Spectrum
  • Gluten Free
  • Lab Certified
  Servings per day Days supplied in one package Cost per week
Low Dosage (15 mg/day) 0.60 50.0 $13.30
Mid Dosage (45 mg/day) 1.80 16.7 $39.90
High Dosage (90 mg/day) 3.60 8.3 $79.80

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Suggested CBD Dosage for Atherosclerosis

Dosage Per Day

Low

15 mg

Mid

45 mg

High

90 mg

People usually wonder precisely how much CBD is needed to treat a given condition. While in a perfect world, we could simply provide the exact number for each issue, things aren’t that simple. Each person is slightly different and is going to require a somewhat different ideal course of action.

However, that doesn’t mean we can’t offer a solid jumping-off point for users to begin their experimentation. According to experts at DailyCBD, between 15mg and 30mg is an excellent place to start when looking to treat atherosclerosis with CBD.

While CBD is perfectly legal in most parts of the US now, there are still plenty of places that treat THC and CBD the same. As such, it’s crucial to do your research before taking CBD with you on the road.

It’s also worth mentioning that not all CBD products will be 100% THC free. Some find that a bit of THC mixed with CBD helps facilitate the desired benefits. It’s important to keep this in mind whenever looking to buy a new CBD product.

Whatever kind of CBD you take, and however you decide to take it, we hope you choose to leave your experiences here for others to learn from. Newcomers are often discouraged by the mountain of information. So let’s do everything we can to make sure the next person’s journey is a bit easier.

Tracking CBD Effectiveness For Atherosclerosis

It’s often difficult for those just starting on CBD to understand exactly how well it’s working for them. This is a common problem, so while it can be very annoying, it’s perfectly normal. As such, we suggest people stick with it before making a final judgment. CBD has a relatively subtle impact even when working correctly, so it does take some time to notice.

To help people start to zero in on the real impact of CBD, we tell users to keep a short journal of their experiences. All it takes is a basic description of symptoms along with the dose taken that day, and most people can start understanding precisely how CBD is working for them.

Each person is going to require a slightly different ideal regimen, so good old fashioned experimentation is the only way to really know you’re getting the most out of your CBD. It can seem daunting, but all it takes is paying a bit of attention.

Some people ask if they have to keep a journal for CBD to work effectively. While it’s not entirely required, we firmly believe this makes a massive difference for anyone just starting out taking CBD.

If you do decide to track your progress with CBD, we hope you choose to leave a brief description of your experience here. CBD can be quite mysterious for those just starting out, so any information is immensely helpful for newcomers.

Written By
John Mace Alois is lead content creator at the Did CBD Work? project. He’s analyzed over 400 research papers related to Cannabidiol and helped publish over 55 works related to different conditions for the project. He majored in Cultural Anthropology, with a minor in English, from the University at Albany. He is an avid collector of art supplies and refurbishes old furniture in his spare time.

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