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Backpain overview

Published on August 27th, 2019

Last updated on June 3rd, 2020

Back pain means a lot of different things to a lot of different people. For instance, it can be relatively mild and nagging, or it could be very sharp and come out of seemingly nowhere. One thing that’s true for all types of back pain is it can significantly reduce your overall quality of life.

While we know all too well how debilitating chronic back pain can be, we don’t know nearly enough about how to help patients. As with most types of pain, chronic back pain can arise from muscle strain. Fortunately, this type of back pain is typically temporary unless the damage occurs over long periods.

The other most common cause of chronic back pain is what is known as disc disease, which occurs when the discs of the spine start to degenerate and weaken. This happens as a result of factors such as age, genetics, obesity, or even relatively minor injuries. Osteoarthritis, and other conditions such as nerve impingement and stenosis, are also known to be a significant cause of back pain across the globe.

Some of the significant risk factors for these problems include things you’d expect, such as aging and occupational hazards. But a lot fewer people understand how much of a role factors such as genetics and lack of exercise can have on your spine. Even poor posture over a long period, or smoking can be directly related to chronic back pain.

Back pain is, unfortunately, a prevalent issue. Experts believe more than 80% of Americans will experience lower back pain at some point in their lives. The Global point prevalence estimates of low back pain is 9.4%, and this makes it one of the most common causes of disability in the world.

If you or a loved one is struggling with back pain, the best thing you can do is consult a doctor. Only a doctor can accurately diagnose issues and provide the proper treatment.

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Table of Contents

CBD Research For Backpain

potencial impact research overview

Inflammation - Cannabinoids, endocannabinoids, and related analogs in inflammation

  • University of Massachusetts Medical School
  • 2009

related conditions:


A comprehensive review of research looked into the anti-inflammatory effects of different cannabinoids, including CBD. The team set out to provide an overview of everything we know about the connection between cannabinoids and inflammation. Their analysis showed CBD doesn’t suppress eicosanoids production as many anti-inflammatory medications do. In fact, CBD was shown to increase production while still providing inflammation relief.

Inflammation - Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: role for the adenosine A(2A) receptor

  • University of São Paulo
  • 2012

related conditions:


CBD was shown to have “potent immunosuppressive and anti-inflammatory properties.” Their testing was able to confirm that CBD still provides valuable anti-inflammatory value even during acute lung injury. The researchers believe this is most likely due to an increase in the extracellular adenosine which sends signals via the A(2A) receptor.

Inflammation - Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors

  • National Institutes of Health
  • 2012

related conditions:


Researchers wanted to better understand the connection between CBD and pain management via glycine receptors. According to their study of mice, a regimen of CBD can dramatically lower chronic pain and inflammation. Interestingly, it was shown to provide this value without causing increased tolerance or a need for higher dosages.

Inflammation - Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption

  • National Institutes of Health/NIAAA
  • 2007

related conditions:


Research shows that CBD provides significant benefits to chronic inflammation and pain. The team took particular interest in the effect of CBD on high glucose-induced mitochondrial superoxide generation, as well as a host of other specific functions. The high glucose-induction alone provided significant benefits across the board. However, the researchers showed their benefits were all significantly improved by CBD pretreatment.

Inflammation - Cannabinoids in clinical practice

  • The School of Pharmacy
  • 2000

related conditions:


A review of the available information concluded CBD has valuable analgesic and anti-inflammatory effects. Researchers believe CBD should, therefore, be seen as a legitimate alternative to over the counter drugs. The evidence also showed that CBD significantly reduces the anxiety induced by another cannabinoid, THC, and should be studied further.

Parkinson's- Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT(1A) receptors without diminishing nervous system function or chemotherapy efficacy

  • Temple University School of Medicine
  • 2014

related conditions:

Neuropathic Pain

The research concluded CBD provides a protective effect against Paclitaxel induced neurotoxicity in cancer patients. The study indicated CBD doesn’t harm either nervous system function or chemotherapy efficacy. The team also assessed the impact of CBD on several distinct factors, including place conditioning and cancer cell viability.

Parkinson's- Cannabinoids in the management of difficult to treat pain

  • GW Pharmaceuticals
  • 2008

related conditions:

Neuropathic Pain

This review of the available evidence suggests CBD and the endocannabinoid system could play an integral role in pain treatment. Not only do clinical trials show CBD is well-tolerated, but a growing number of researchers agree on their value. Repeated randomized trials have shown CBD based medications are safe and effective in treating central and peripheral neuropathic pain.

Parkinson's- The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain

  • University of Milano-Bicocca
  • 2007

related conditions:

Neuropathic Pain

Researchers wanted to take a deeper look at the anti-inflammatory and immunomodulatory effects of CBD. CBD was administered to rat models daily for two weeks, which resulted in very promising results. The team noted reduced hyperalgesia, which they attributed to a vanilloid antagonist. As such, they believe CBD has the potential to be therapeutic for chronic pain conditions.

Parkinson's- Oromucosal delta9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, open-label, 2-year extension trial

  • Walton Centre for Neurology and Neurosurgery
  • 2007

related conditions:

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A two year trial of CBD concluded it’s an effective treatment for patients with debilitating chronic pain. They found this effect was most potent for central neuropathic pain, like that associated with conditions such as MS. Interestingly, the researchers also found this effect didn’t decrease over time. The only noted symptoms were mild dizziness and nausea.

CBD Research That Might Be Useful for Symptoms of Backpain

potencial impact research overview

Pain Relief - Control of pain initiation by endogenous cannabinoids

  • University of Naples Federico II
  • 1998

related conditions:

Pain Relief

Researchers concluded CBD significantly reduces discomfort and pain, in part, due to the interaction between two substances, PEA and anandamide. According to tests, they “act synergistically, reducing pain responses 100-fold more potently than each compound alone”.

Arthritis - Arthritis and cannabinoids: HU‐210 and Win‐55,212–2 prevent IL‐1 α‐induced matrix degradation in bovine articular chondrocytes in‐vitro

  • Royal Pharmaceutical Society of Great Britain
  • 2006

related conditions:


CBD was shown to have “analgesic, immunomodulatory and anti‐inflammatory properties.” Researchers determined a CBD regimen reduces joint damage from arthritis, mainly by strengthening cartilage. They also noted several different ways in which the body reacts favorably to the introduction of CBD, especially in mitigating the degradation and inflammation induced by cytokines.

Sleep - Cannabis, Cannabinoids, and Sleep: a Review of the Literature

  • Palo Alto University, CA, USA
  • 2017

related conditions:


This report concludes CBD holds promise for significantly increasing the quality of REM sleep. Researchers believe it could one day be a primary force behind improved overall sleep quality. CBD was even shown to reduce daytime sleepiness in many patients.

Backpain & CBD Research Overview

There’s no shortage of debilitating conditions that CBD has been shown to improve greatly. In few areas has this been more obvious than when it comes to chronic pain, especially back pain. In just the last 20 years, we’ve learned an incredible amount about how and why CBD is an effective treatment for back pain.

CBD is a well-tolerated substance. A report called Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT(1A) receptors without diminishing nervous system function or chemotherapy efficacy, tested the impact of CBD on the nervous system function and chemotherapy efficacy of cancer patients. They suggested that not only is CBD well-tolerated but that it also offers protection against neurotoxicity.

Other studies have also noted how beneficial vaping can be, particularly in regards to pain treatment. Cannabinoids in the management of difficult to treat pain is a report which reviewed all the available clinical trials on CBD. The report suggested that a growing number of researchers agree CBD is a safe and effective medication for both central and peripheral neuropathic pain. Further research is needed to ascertain the beneficial effect of CBD on other chronic pain like CLBP.

Studies such as Control of pain initiation by endogenous cannabinoids, suggests that vaping is a relatively effective tool in treating chronic pain. In fact, the report concluded the interaction between two substances, PEA and anandamide, provides pain relief an estimated 100-fold more potent than either substance alone.

This positive impact on people living with back pain has been noted many times. A report called Arthritis and cannabinoids: HU‐210 and Win‐55,212–2 prevent IL‐1 α-induced matrix degradation in bovine articular chondrocytes in‐vitro indicated a regimen of CBD could greatly reduce joint damage by strengthening cartilage. It must be stated that this is a report of tests carried out on animals and not on humans.

Other reports have indicated the benefit is derived from interaction with glycine receptors across the body. A study of mice, called Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors, concluded CBD could lower chronic pain and inflammation.

Finally, reviews of the available information have proven quite beneficial in this debate, firmly stated CBD A report, called Cannabinoids in clinical practice suggests that CBD has invaluable analgesic and anti-inflammatory effects. As such, these researchers believe it could even one day become a viable alternative to over the counter pain medications.


Commentary by Ahmed Diab M.D

“CBD effects on chronic pain has been the most studied indication for this substance in the literature, debilitating effects on quality of life. Trials on use of cannabinoid derivatives for chronic back pain are scarce in the literature. However, the effects on chronic neuropathic pain and inflammation are encouraging and warrant further trials to explore possibility of including Cannabinoid derivatives in management of chronic back pain.”

Best CBD for Backpain

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NoteCBD Capsules (25mg)

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Enjoy the benefits of hemp extract with the convenience of a capsule. Each capsule contains a pre-portioned dose of full-spectrum hemp extract and MCT oil.

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NoteCBD Capsules (10mg)

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Enjoy the benefits of hemp extract with the convenience of a capsule. Each capsule contains a pre-portioned dose of full-spectrum hemp extract and MCT oil.

  • CBD Per Serving: 10mg
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Suggested CBD Dosage for Backpain

Dosage Per Day


10 mg


25 mg


45 mg

One question we seem to answer all the time is how much CBD should you take. If it were as simple as providing a number and calling it a day, we would gladly oblige. However, the human body is very complex, and what works for one person may only provide a mild improvement for others.

As such, the best way to find your ideal dose is by experimenting and trying lots of different combinations. CBD is a non-psychoactive substance, meaning you won’t have to worry about getting high if you accidentally take too much.

Even though we can’t offer a cure-all dosage suited for everyone, we can suggest a solid starting point from which to start your journey. Some researchers have suggested that the inflammation which leads to back pain can often require larger doses of CBD, between 15mg and 45mg daily just like in morphine use./ This will, of course, depend on your size and other factors, but for most people, this range is a reasonable point to start. But, like in a medication, a physician should be consulted.

It’s here we always like to mention that while CBD has become increasingly accepted around the country, there are still plenty of places which still treat CBD the same as THC. As such, always ensure your local laws allow for CBD before purchasing any, and especially before traveling.

Lastly, make sure to check your CBD product of choice is 100% CBD if you’re not interested in getting high. This is because some CBD products will include a bit of THC to help bolster the effects.

Whatever type of CBD you buy, and however much you end up taking, the best thing you can do is keep track of your symptoms. While it can feel a bit awkward at first, the bottom line is keeping a journal will help you get the most out of your CBD.


This disclaimer informs readers that ONLY COMMENTARY expressed in this file belong solely to Ahmed Diab, M.D., and not necessarily to the author’s employer, organization, committee, or other group or individual.

Tracking CBD Effectiveness For Backpain

Most people have no idea what to look for when they first start taking CBD. After all, as a non-psychoactive substance, it’s effect can be a bit subtle. Luckily, when it comes to pain, you’re probably already well aware of your symptoms on a day-to-day basis.

One thing we suggest all people do is starting a journal when you begin taking CBD. By simply tracking your dosage and symptoms daily, you’d be shocked how much clearer it can make your progress. We get questions all the time from people wondering how they can be keep track of things, and this is it.

The fact is, everyone is different and will react to medications in slightly different ways. It also takes your system some time to adjust to the new substance, so be patient. After a few weeks of keeping track of your symptoms, it should be very easy to know if it’s been effective for you or not.

The hands-down best thing about keeping a journal is how easy it makes it to differentiate your symptoms. When taking CBD for something like back pain, it’s essential to pay particular attention to any inflammation, aches, or sharp pain you experience.

Regardless of which method you choose to track your progress, we hope you’ll decide to leave a brief comment below detailing your experience. All it takes is a brief description, along with a score between 1-10 for how well you felt CBD improved your pain, inflammation, and restlessness. While it’s not a lot to ask, it could make a huge difference for someone else.

Written By
John Mace Alois is lead content creator at the Did CBD Work? project. He’s analyzed over 400 research papers related to Cannabidiol and helped publish over 55 works related to different conditions for the project. He majored in Cultural Anthropology, with a minor in English, from the University at Albany. He is an avid collector of art supplies and refurbishes old furniture in his spare time.
Reviewed By*
Ahmed Diab, M.D is a graduate of Ain Shams University in Cairo, Egypt. Senior He is currently Senior Medical Writer at NegidaClin. He has written dozens of manuscripts for pharmaceutical enterprises. He published works also included drug safety and efficacy for those with Parkinsons Disease and a historical analysis of the performance of prostheses in femoral neck fractures.

*The information contained here does not constitute medical recommendations. Ahmed Diab does not recommend a certain dosage or a certain indication for any of our products. Please consult your personal physician before using any product.

1 CBD Experience From Backpain Suffers

    Ben Hammans

    • May 5, 2020
    This is a test about back pain


    Also effective for:

    • Inflammation
    • Pain Relief
    • Restlessness



    CBD Type:

    CBD & THC

    How Did You Take It?:


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