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Cancer Pain overview

The term cancer covers a broad range of diseases, which all impact the growth of cells and cause severe complications. A common problem for those faced with any cancer diagnosis is some level of moderate to severe pain. While not everyone who has cancer will experience cancer-related pain, it can take many forms and happen anywhere.

Cancer pain is liable to occur in any form. It’s known to be anything from dull to achy, sharp, or even burning. Some people experience relatively mild or moderate discomfort, while others will face crippling pain. This pain can be intermittent for some, while it’s a constant battle for others. Given the extensive range, the best way to find the right path forward is by working with a medical professional you know and trust.

It’s important to be your own advocate when talking to your doctors about cancer pain. While there are many ways to deal with pain in the short term, many can do more damage than good if abused. You must work closely with your doctor to identify a workable plan that is built around your life and symptoms.

Cancer pain often becomes a more prevalent and severe issue once a given type of cancer has metastasized. The spread of cancer is one of the most dangerous complications of any type of cancer, as once this occurs, treatment becomes much tougher. When it comes to cancer pain, the spreading process often causes pain in the tissues nearby.

The pain is generally caused by the cancer cells, either growing into or destroying the healthy cells and nerves. The more cancer grows, the more pressure is placed on surrounding tissues, organs, and bones. Another way cancer is known to cause pain is via the release of certain chemicals into the system, which induces pain.

For others, the other cancer-related pain they will experience will be associated with their treatment and not cancer itself. This is typical after surgery or as a result of radiation treatments and chemotherapy. Other risk factors of chronic cancer pain include reluctance to discuss health with professionals and fear of addiction.

While we don’t have reliable estimates for how many people deal with cancer-related pain, it’s clear from reports that a vast majority of cancer patients will deal with pain at one point in the process or another. Given that nearly 7 million people across the globe die each year from cancer, we all know how serious of a problem it is. Improving quality of life often becomes paramount in cancer treatments, and pain relief is a surefire way to reduce suffering.

Cancer of any type is extremely serious. If you’re worried you or a loved one could be facing this diagnosis, don’t wait to talk to your doctor as soon as possible. Only they can offer an accurate scope of the problem and get you on the path forward. The sooner treatment is undertaken, the better the chances of a full recovery.

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Table of Contents

CBD Research For Cancer Pain

potencial impact research overview

Cancer Pain - Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain

  • Severn Hospice
  • 2010

related conditions:

Cancer

This study compared the efficacy of using a THC/CBD extract, a THC extract, and a placebo in relieving pain in patients facing advanced cancer. Their results noted a statistically significant change in the mean pain Numerical Rating Scale in favor of the THC/CBD extract over the pure THC extract and control. This research demonstrates the efficacy of using exogenous cannabinoids for pain relief for patients with advanced cancer not adequately managed by opioids.

Cancer Pain - Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial

  • Beth Israel Medical Center
  • 2012

related conditions:

Cancer

In a randomized, double-blind, placebo-controlled, graded-dose study, researchers explored the efficacy of using cannabinoids to treat patients with advanced cancer and opioid-refractory pain. In their findings, the authors noted the proportions of patients reporting analgesia was higher in the cannabinoid group over placebo. They conclude this study supports both the efficacy and safety of using cannabinoids as an analgesic in patients with opioid-refractory cancer pain.

Cancer Pain - Marijuana extract helps prevent chemo pain

  • Temple University
  • 2011

related conditions:

Cancer

The author of this article reviews a 2011 study on the effects of administering CBD to treat neuropathy caused by chemotherapy. The study’s results showed that CBD pretreatment before chemotherapy effectively prevented abnormal pain development, which may be permanent. There was no evidence of neuropathy even after pretreatment had ended. The author notes that while these results are promising, additional research is needed to evaluate the effects and underlying mechanisms using human models.

Cancer Pain - An Open-Label Extension Study to Investigate the Long-Term Safety and Tolerability of THC/CBD Oromucosal Spray and Oromucosal THC Spray in Patients With Terminal Cancer-Related Pain Refractory to Strong Opioid Analgesics

  • University of Edinburgh
  • 2013

related conditions:

Cancer

In this follow-up study, researchers investigated the long-term safety and tolerability of using THC/CBD and THC sprays in patients with advanced cancer. Their results found an improvement in both pain severity and worst pain ratings, as well as an increase in scores regarding insomnia, pain, and fatigue. The authors conclude this study shows the long-term use of THC/CBD spray is well tolerated, and noted patients did not seek to increase their dose of it or other pain-relieving medications over time.

CBD Research That Might Be Useful for Symptoms of Cancer Pain

potencial impact research overview

Pain Relief - Control of pain initiation by endogenous cannabinoids

  • University of Naples Federico II
  • 1998

related conditions:

Pain Relief

Researchers concluded CBD significantly reduces discomfort and pain, in part, due to the interaction between two substances, PEA and anandamide. According to tests, they “act synergistically, reducing pain responses 100-fold more potently than each compound alone”.

Inflammation - Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice

  • Tongji University School of Medicine
  • 2013

related conditions:

Inflammation

A study of mice concluded CBD has significant anti-inflammatory effects. The researchers also saw evidence that the expression of the GPR55 receptor was improved after starting on CBD. Treatment with CBD was shown to significantly decrease the levels of several inflammation-related chemicals in test subjects.

Nausea - Interaction between non-psychotropic cannabinoids in marijuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews

  • Palo Alto University, CA, USA
  • 2017

related conditions:

Nausea

CBD was shown to significantly suppress vomiting in lab rats and shrews. Researchers used another substance, known as cannabigerol (CBG) to reverse this suppression. Moderate doses of CBG and CBD are opposing each other at the 5-HT1A receptor, which is known to play an essential role in regulating nausea.

Cancer Pain & CBD Research Overview

It’s only taken the last 15 years of research to uncover a mountain of different things that CBD can potentially help with. It wasn’t all that long ago, most people didn’t know what CBD was, and if they did, they likely saw it as little more than the less important little brother of THC. However, all this new research has dramatically shifted that perspective. These days we know CBD may be an effective treatment for many issues, including cancer-related pain.

Researchers have known for a while now that the combination of THC and CBD has some powerful pain-relieving effects. Reports such as Multicenter, double-blind, randomized, placebo-controlled, parallel-group study of the efficacy, safety, and tolerability of THC:CBD extract and THC extract in patients with intractable cancer-related pain have provided ample evidence that this mixture is helpful even in cases of advanced cancer-related pain.

Other teams have reached similar conclusions, including the team behind An Open-Label Extension Study to Investigate the Long-Term Safety and Tolerability of THC/CBD Oromucosal Spray and Oromucosal THC Spray in Patients With Terminal Cancer-Related Pain Refractory to Strong Opioid Analgesics. The researchers found that even in advanced cancer patients, CBD and THC mixtures provide reliable protection against debilitating pain.

However, other reports have taken things a step further and suggested CBD alone could still provide some valuable benefits to those dealing with severe cancer pain. Marijuana extract helps prevent chemo pain, for example, reviewed earlier reports on the impact of CBD on cancer-related pain. Researchers concluded that pretreatment with CBD before chemo was able to reduce the development of abnormal cancer-related pain significantly. Even more impressively, this also seemed to have this impact on what could become permanent pain, as there was no reduction in neuropathy after pretreatment ended.

Further reports on the power of cannabinoids to improve cancer-related pain have proven it’s extremely well tolerated. Nabiximols for opioid-treated cancer patients with poorly-controlled chronic pain: a randomized, placebo-controlled, graded-dose trial showed CBD trial groups had much less pain than placebo groups. At the same time, the lack of psychoactive effects was also a noted positive for CBD as a pain med.

Finally, some reports have shown that certain CBD-related cannabinoids may work in conjunction to provide a much more powerful effect than either does on their own. Control of pain initiation by endogenous cannabinoids found that the interaction between PEA and anandamide are responsible for increasing the pain-relieving benefits provided by “100-fold”.

Other reports have highlighted how CBD, aside from pain relief, could improve the lives of those dealing with cancer. Several reports have noted more indirect benefits, including Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice. The team tested the anti-inflammatory properties of CBD and found evidence that it’s an interaction with the GPR55 receptors, providing this benefit. Interestingly, the team found CBD treatment could significantly reduce the levels of substances in the system, which contributes to painful inflammation.

Additionally, many who are going through cancer treatment will experience severe and sometimes painful nausea. That said, CBD is also known to provide some significant anti-nausea benefits for those suffering. A report called, Interaction between non-psychotropic cannabinoids in marijuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews concluded CBD expresses the 5-HT1A receptors to reduce nausea symptoms.

Best CBD for Cancer Pain

Pure CBD Oil Capsules, (50mg)

Pure CBD Oil Capsules, (50mg)

description

Every Day Optimal Soft Gel PCR Hemp Oil Capsule contains 50mg of pure CBD.

$119.99
  • CBD Per Serving: 50mg
  • Number Of Servings: 30
  • Cost Per Serving: $4.00
  • Cost Per/mg of CBD: $0.08
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advantages

  • Easy Capsule Form
  • All Natural
  • GMP Compliant
  Servings per day Days supplied in one package Cost per week
Low Dosage (20 mg/day) 0.40 75.0 $11.20
Mid Dosage (100 mg/day) 2.00 15.0 $56.00
High Dosage (200 mg/day) 4.00 7.5 $111.99

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Diamond CBD Full Spectrum Honey Tincture (2500mg)

Diamond CBD Full Spectrum Honey Tincture (2500mg)

description

These tasty new honey tinctures are made of 100% all-natural honey, presenting a delicious addition to how to deliver you with the ideal amount of CBD. Available in strengths ranging from 25mg to 3500mg, add it to your morning coffee, tea, or just use it throughout the day to sweeten up every moment while enjoying all of the awesome benefits that CBD offers.

$128.00
  • CBD Per Serving: 83.33mg
  • Number Of Servings: 30
  • Cost Per Serving: $4.27
  • Cost Per/mg of CBD: $0.05
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advantages

  • Honey Flavor
  • Control Over Dosing
  • All Natural Ingredients
  Servings per day Days supplied in one package Cost per week
Low Dosage (20 mg/day) 0.24 125.0 $7.17
Mid Dosage (100 mg/day) 1.20 25.0 $35.84
High Dosage (200 mg/day) 2.40 12.5 $71.68

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Relax Full Spectrum CBD Oil (3500mg)

Relax Full Spectrum CBD Oil (3500mg)

description

Relax Full Spectrum CBD Oil, available with an oil tincture dropper, delivers the ideal amount of CBD to meet all of your wellness needs. Made in the USA  from 100% high quality industrial hemp, this 3500 mg bottle of CBD is perfect for those wanting to combat stress, anxiety, and chronic pain.

$168.00
  • CBD Per Serving: 116.67mg
  • Number Of Servings: 30
  • Cost Per Serving: $5.60
  • Cost Per/mg of CBD: $0.05
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advantages

  • 100% Hemp Product
  • Made in USA
  • Full Spectrum
  Servings per day Days supplied in one package Cost per week
Low Dosage (20 mg/day) 0.17 175.0 $6.72
Mid Dosage (100 mg/day) 0.86 35.0 $33.60
High Dosage (200 mg/day) 1.71 17.5 $67.20

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Suggested CBD Dosage for Cancer Pain

Dosage Per Day

Low

20 mg

Mid

100 mg

High

200 mg

The most common question we ever get likely is how much CBD is needed to treat a specific condition or symptom. While it would be fantastic if it were that simple, the truth is we can only get so close to a perfect dosage for everyone. Each person has to determine for themselves what works best.

While we can’t provide the exact dose, we can offer a solid starting point. According to research, between 20-50mg of CBD can be effective at treating various levels of cancer-related pain. Researchers suggest starting lower and increasing doses over time to suit your needs.

It’s important to remember that while CBD is becoming more popular by the day, it’s still not legal everywhere. In fact, the legality can be quite grey, depending on where you find yourself. It’s important always to do your due diligence when traveling, or you could end up with CBD in a place that treats it as illegal.

Another vital thing to remember for anyone looking to purchase CBD is that not all CBD products will be THC-free. In fact, many find a bit of THC can improve the effectiveness to some degree. That said, if you’re unwilling or unable to experience any psychoactive effects, you must make sure only to buy THC-free products.

It’s not uncommon for people to feel overwhelmed when first entering the world of CBD. After all, there’s a whole lot of information to wrap your head around, and that doesn’t even count any misinformation out there. As such, it’s a great resource to have trustworthy user-generated reviews helping guide your journey. We hope you choose to be part of our movement and leave your experience here for the next person struggling.

Tracking CBD Effectiveness For Cancer Pain

Lots of people who are just beginning their CBD treatment will face trouble determining exactly how well it’s working. While this is very frustrating, it’s essential not to let this discourage you. Even when working correctly, CBD has a relatively subtle impact on most conditions. The best thing you can do is pay attention to your body.

One of the absolute best ways we’ve ever found to help people zero in on their ideal dosages is keeping a journal. It can seem trivial at first, but after a few weeks of tracking your daily dosages and subsequent symptoms, most people feel much better equipped to say if CBD is sufficient for them.

By far, the most impactful thing on how well CBD works for you will be your personal biology. What is ideal for one person could be way too much for another. This is why it’s so critical to do experimentation for yourself and pay attention to the results.

Many people ask us if keeping this journal is entirely necessary to find success with CBD. While, of course, you don’t need to do this, we firmly stand behind the ability of this simple trick to impact the effectiveness of your CBD dramatically.

Whichever way you choose to start tracking your CBD usage, we hope you decide to leave that experience here for the newcomers. We can all remember how daunting it was when we first got CBD and had no good feel for what worked best. By taking a couple of minutes and providing a description of your time taking CBD and a score for how well it improved any pain, inflammation, and anxiety, you could make a significant difference in the life of someone who’s suffering.

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