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Crohn's overview

Published on October 15th, 2019

Last updated on June 6th, 2020

Crohn’s colitis is a type of inflammatory bowel disease. It is a debilitating gastrointestinal conditions, which can greatly affect your quality of life. This medical condition causes pain and swelling of the digestive tract. Crohn’s and Ulcerative Colitis make up the vast majority of IBD cases.

Crohn’s disease is a chronic condition that leads to ulcers in various parts of the intestine, along with inflammation. While it usually only affects the lower small intestine, it can occur anywhere along the digestive tract, including the mouth. Crohn’s affect the whole bowel. Ulcerative colitis affects the rectum and large intestine.

Both condition results in ulcers, which can be painful when irritated. Another similarity is that both diseases are characterized by remission and relapses. But, one key difference is that while Ulcerative Colitis only affects the lining of the colon, Crohn’s can sometimes develop deep into the layers of the bowel wall.

IBD, such as Crohn’s and Ulcerative Colitis, are most likely related to genetics and the immune system. Researchers believe that in patients with IBD, the immune system and digestive tract mistakenly identify food as a foreign invader, and floods the system with white blood cells to try and fight the intruder. This influx of white blood cells is what causes different symptoms of IBD.

While researchers know how they develop, they have yet to fully uncover why. Some evidence suggests this critical mistake in the immune system can be traced to a virus or bacteria. Some evidence even shows it could be exacerbated by simple allergies. Other risk factors, such as sex, vary between the conditions, with men being more susceptible to ulcerative Colitis, while Crohn’s is more common in women.

An estimated 3.1 million Americans deal with an IBD condition according to a 2015 survey by the CDC. A 2018 report by Crohn’s and Colitis Canada titled, IMPACT OF INFLAMMATORY BOWEL DISEASE stated that this represented an over 50% increase in patients since 1999 when only 2 million adults dealt with Crohn’s or Ulcerative Colitis. As such, experts are working harder than ever to uncover safe and effective treatments for these debilitating IBD conditions.

If you are worried that you, or someone in your life, maybe dealing with Crohn’s or ulcerative Colitis, the best thing you can do is speak to your doctor as soon as possible. Only a doctor can provide a legitimate diagnosis, as well as provide the most accurate and pertinent information for your case.

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Table of Contents

CBD Research For Crohn's

potencial impact research overview

Crohn's & Colitis - Cannabidiol in inflammatory bowel diseases: a brief overview

  • Sapienza University of Rome
  • 2013

related conditions:

Crohns & Colitis

This review of the available research wanted to determine the value of CBD when added to traditional anti-inflammatory treatments. The researchers concluded that thanks to the rise in popularity of CBD, the regulatory benefits of cannabinoids could finally be leveraged by gastroenterologists. Their analysis concluded CBD should be considered a potential candidate for new forms of IBD control.

Crohn's & Colitis - Cannabis finds its way into treatment of Crohn's disease

  • Medical University of Graz
  • 2014

related conditions:

Crohns & Colitis

Cannabis has long been known as an effective treatment for all sorts of inflammatory issues, especially in the gut. This clinical study proves that CBD and other cannabinoids live up to the reputation they have for being able to regulate digestive systems. They believe this impact can most likely be traced to the CB1 and CB2 receptors.

Crohn's & Colitis - Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis

  • University of Naples Federico II
  • 2011

related conditions:

Crohns & Colitis

Researchers wanted to better understand how CBD can control the reactive gliosis in the CNS. The data indicates several critical ways in which CBD can help regulate inflammatory bowel diseases. For example, CBD reduced expression of S100B and iNOS, as well as mediated critical receptor pathways, such as PPAR-gamma. This mediation was shown to reduce intestinal damage significantly.

Crohn's & Colitis - Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis

  • University of Naples Federico II
  • 2009

related conditions:

Crohns & Colitis

According to researchers, despite the increasing prevalence of inflammatory bowel conditions, available treatments are severely lacking. As such, the team wanted to determine if CBD is a potential additional treatment option for millions of people. They tested the impact of CBD on several key factors, including oxidative stress. The researchers found ample evidence that CBD effectively prevents inflammatory issues in mice, warranting further testing.

Crohn's & Colitis - The effects of Delta-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis

  • University of Hertfordshire
  • 2010

related conditions:

Crohns & Colitis

CBD was shown to reduce inflammation in the intestines, as well as to lower occurrences of other functional disturbances. As such, the team believes CBD should be leveraged as either an additive to other treatments or as a standalone drug. The team tested the value of CBD in rat models to reduce damage, inflammation, as well as in vitro colonic motility.

Crohn's & Colitis - Topical and systemic cannabidiol improves trinitrobenzene sulfonic acid colitis in mice

  • Medical University of Graz
  • 2012

related conditions:

Crohns & Colitis

The team wanted to determine which methods of application are most effective for CBD. It’s been well documented that injections of CBD can significantly reduce intestinal inflammation, but other methods haven’t been researched as much. They tested the effectiveness of both oral and rectal CBD application in the treatment of inflammation. Data suggests that intrarectal delivery of CBD can have a significant impact on colonic inflammation.

Crohn's & Colitis - Cannabinoids and the gut: new developments and emerging concepts

  • University of Naples Federico II
  • 2010

related conditions:

Crohns & Colitis

CBD and other endocannabinoids have been known to provide significant benefits for those dealing with gastrointestinal inflammation. Research has proven that endocannabinoid receptors are all over your intestinal tract, with regional variation and organ-specific actions. The team found several ways in which CBD can positively impact the digestive system, especially in regards to treating various gastrointestinal diseases.

Crohn's & Colitis - Endocannabinoids and the gastrointestinal tract

  • Johannes Gutenberg-University Mainz
  • 2006

related conditions:

Crohns & Colitis

Endocannabinoids, including THC and CBD, have been known for years to provide significant improvements for people dealing with gastrointestinal issues, including pain, diarrhea, and gastroenteritis. Their analysis concludes that the endocannabinoid system may offer a new and practical pathway for treating GI disorders, especially inflammatory conditions.

Crohn's & Colitis - Cannabinoids and gastrointestinal motility: animal and human studies

  • University of Naples Federico II
  • 2008

related conditions:

Crohns & Colitis

The team determined modulation of the digestive endocannabinoid system could provide a significant benefit to those dealing with gastrointestinal inflammation. Research suggests the CB1 and CB2 receptors reduces excitatory enteric transmission of different regions of the digestive tract. As such, they believe CBD could be a viable treatment for a wide range of inflammatory stimuli.

Crohn's & Colitis - Cannabis in Primary Care

  • University of California, San Francisco
  • 2013

related conditions:

Crohns & Colitis

Research indicates CBD positively impacts the gastrointestinal system in several key ways. These included regulating the motility and intestinal secretions, as well as reducing overall inflammation and pain in patients. Most impressively, a full half of the patients in their study were able to stop taking at least one daily medication thanks to CBD. The early research has been so promising, the researchers strongly advocate for more in-depth inquiry.

CBD Research That Might Be Useful for Symptoms of Crohn's

potencial impact research overview

Sleep - Cannabis, Cannabinoids, and Sleep: a Review of the Literature

  • Palo Alto University, CA, USA
  • 2017

related conditions:

Sleep

This report concludes CBD holds promise for significantly increasing the quality of REM sleep. Researchers believe it could one day be a primary force behind improved overall sleep quality. CBD was even shown to reduce daytime sleepiness in many patients.

Pain Relief - Control of pain initiation by endogenous cannabinoids

  • University of Naples Federico II
  • 1998

related conditions:

Pain Relief

Researchers concluded CBD significantly reduces discomfort and pain, in part, due to the interaction between two substances, PEA and anandamide. According to tests, they “act synergistically, reducing pain responses 100-fold more potently than each compound alone”.

Anxiety - Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence

  • University of Melbourne, Australia
  • 2013

related conditions:

Anxiety

A comprehensive review of all the plant-based medicine which has had both preclinical and human clinical trials conducted about their anxiolytic-like effect. An analysis of over 1500 papers identified 21 plants which had been adequately tested, with one of the most successful of these plants found to be CBD enriched Cannabis species.

Crohn's & CBD Research Overview

You don't have to look very far these days to find people whose lives have been changed forever by the power of CBD. Not long ago, CBD was seen as little more than the little brother to THC, but as more research is published, more is being known about CBD. This is even more apparent when it comes to gastrointestinal conditions such as Crohn's and Colitis.

There has been a lot of research published over the last 15 years, which strongly suggests CBD could provide incredible anti-inflammatory benefits for those living with a chronic condition.

Other reports have also noted this incredible anti-inflammatory benefit of CBD. In another study, the role of Cannabis in the management of inflammatory bowel diseases was investigated and discussed. The report, commissioned by the Crohn’s and Colitis Foundation also suggested that Cannabinoid extracts have therapeutic benefits in the treatment of IBD.

Researchers have started to study how different ways of taking CBD can impact its effectiveness at treating Crohn's and Colitis. In an animal report, called Topical and systemic Cannabidiol improves trinitrobenzene sulfonic acid colitis in mice, tested various methods of CBD application, including injections, oral, and rectal administration. They concluded, based on their animal trials, that intrarectal delivery of CBD might be particularly useful at treating colonic inflammation.

The prevalence of the endocannabinoid receptors in the digestive system has been proven by other reports, such as Cannabinoids and the gut: new developments and emerging concepts. Researchers concluded CBD interacts with receptors throughout your intestines with regional variation and organ-specific actions.

A research work conducted through an online survey observed that many patients in Australia illicitly use medical cannabis to manage their IBD and that many claimed that the treatment was effective. The report concluded by suggesting that further clinical trials are required to validate or refute, patient claims about the efficacy of medical cannabis in the management of IBD.

Further research into the impact of CBD on Crohn's and ulcerative Colitis has shown some potentials. Cannabidiol reduces intestinal inflammation through the control of the neuroimmune axis. The researchers explored possible mechanisms that CBD can control IBD with the reactive gliosis in the CNS, as well as helping mediate important receptor pathways. They suggested that overall, CBD could significantly reduce intestinal damage sustained from IBD.

In another animal report, some experts looked into the possibility of CBD being a useful additive to existing Crohn's and Colitis treatment plans. Cannabidiol, a safe and non-psychotropic ingredient of the marijuana plant Cannabis sativa, is protective in a murine model of colitis was able to prove CBD dramatically reduces oxidative stress and damage in the intestines, as well as preventing inflammation.

Another animal report called, The effects of Delta-tetrahydrocannabinol and cannabidiol alone and in combination on damage, inflammation and in vitro motility disturbances in rat colitis, found CBD can reduce damage and inflammation in the intestines. The team also found that CBD is effective as either a standalone drug or in combination with many other medications.

These gastrointestinal benefits don't stop here either. Other animal reports like, Endocannabinoids and the gastrointestinal tract found that CBD significantly reduces intestinal pain, diarrhea, and gastroenteritis. Similarly, Cannabis in Primary Care followed IBD patients who used CBD to control their symptoms.

Using Mouse as a test case, it has been shown in various studies that modulation of the endocannabinoid system, which plays a prominent role in the pathogenesis of IBD and also regulates other functions in the body, has a therapeutic effect in ulcerative colitis. Other researchers have noted that a sizeable number of IBD patients with severe diseases, uses cannabis or its extracts to relieve symptoms of pain or nausea or to increase appetite.

There have been reports that some patients have claimed relief for pain-related ailments, without the intoxicating adverse effects of medical marijuana. One particular study suggests that research has shown the endocannabinoids signaling pathway, through the CB2 receptor, has the potential of reducing colitis-associated inflammation.

 

Commentary by Ahmed Diab M. D.

“There is uncertainty surrounding the effects of cannabis extracts on Inflammatory bowel disease(IBD). No strong conclusions regarding the effectiveness and safety can be drawn. There is no evidence currently that supports CBD for the maintenance of remission in IBD. Further studies with a larger number of participants are required to assess the effects of cannabis in people with IBD”

Best CBD for Crohn's

NoteCBD Capsules (25mg)

NoteCBD Capsules (25mg)

description

Enjoy the benefits of hemp extract with the convenience of a capsule. Each capsule contains a pre-portioned dose of full-spectrum hemp extract and MCT oil.

$95.00
  • CBD Per Serving: 25mg
  • Number Of Servings: 30
  • Cost Per Serving: $3.17
  • Cost Per/mg of CBD: $0.13
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advantages

  • Full Spectrum
  • Gluten Free
  • Lab Certified
  Servings per day Days supplied in one package Cost per week
Low Dosage (60 mg/day) 2.40 12.5 $53.20
Mid Dosage (95 mg/day) 3.80 7.9 $84.23
High Dosage (140 mg/day) 5.60 5.4 $124.13

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Pure CBD Oil Capsules, (50mg)

Pure CBD Oil Capsules, (50mg)

description

Every Day Optimal Soft Gel PCR Hemp Oil Capsule contains 50mg of pure CBD.

$119.99
  • CBD Per Serving: 50mg
  • Number Of Servings: 30
  • Cost Per Serving: $4.00
  • Cost Per/mg of CBD: $0.08
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advantages

  • Easy Capsule Form
  • All Natural
  • GMP Compliant
  Servings per day Days supplied in one package Cost per week
Low Dosage (60 mg/day) 1.20 25.0 $33.60
Mid Dosage (95 mg/day) 1.90 15.8 $53.20
High Dosage (140 mg/day) 2.80 10.7 $78.39

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NoteCBD Capsules (10mg)

NoteCBD Capsules (10mg)

description

Enjoy the benefits of hemp extract with the convenience of a capsule. Each capsule contains a pre-portioned dose of full-spectrum hemp extract and MCT oil.

$45.00
  • CBD Per Serving: 10mg
  • Number Of Servings: 30
  • Cost Per Serving: $1.50
  • Cost Per/mg of CBD: $0.15
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advantages

  • Full Spectrum
  • Lab Certified
  • Organic
  Servings per day Days supplied in one package Cost per week
Low Dosage (60 mg/day) 6.00 5.0 $63.00
Mid Dosage (95 mg/day) 9.50 3.2 $99.75
High Dosage (140 mg/day) 14.00 2.1 $147.00

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Suggested CBD Dosage for Crohn's

Dosage Per Day

Low

60 mg

Mid

95 mg

High

140 mg

Many people wonder how much CBD is the right amount to take for their condition. Unfortunately, the best we can offer is a solid starting point, but finding the ideal dosage for your system requires some experimentation.

The good news is that since CBD is non-psychoactive, you don’t have to worry about any impairing effects from taking too much. Everyone is different, so what might work perfectly for one person might barely have an effect on another.

While we can’t give you the precise dosage, we can provide an excellent place to begin. According to a clinical trial, anyone looking to start taking CBD

for their Crohn’s or Colitis should start with 50mg of CBD twice a day, working their dosage up if the drug is well-tolerated to 250mg twice daily.

One thing to keep in mind, no matter what you’re taking CBD for, is the complicated legality. While CBD has quickly grown into a vibrant, mainstream business in much of the country, other places are still treating CBD and THC as essentially the same. So be sure to check local laws before purchasing CBD, and especially before traveling.

Another thing to keep in mind is only buying 100% CBD products. Some people have found CBD combined with a bit of THC more readily treats their conditions, so companies often offer these variants. If you’re not interested in getting “high,” always make sure to double-check your chosen product is THC free.

Regardless of how you take your CBD, the best thing to do is keep a journal of your progress. Most people are amazed when they see how much of a difference it can make. If you want to maximize the effectiveness of your CBD, there are few things better.

One thing to keep in mind, no matter what you’re taking CBD for, is the complicated legality. While CBD has quickly grown into a vibrant, mainstream business in much of the country, other places are still treating CBD and THC as essentially the same. So be sure to check local laws before purchasing CBD, and especially before traveling.

Another thing to keep in mind is only buying 100% CBD products. Some people have found CBD combined with a bit of THC more readily treats their conditions, so companies often offer these variants. If you’re not interested in getting “high,” always make sure to double-check your chosen product is THC free.

Regardless of how you take your CBD, the best thing to do is keep a journal of your progress. Most people are amazed when they see how much of a difference it can make. If you want to maximize the effectiveness of your CBD, there are few things better.

 

This disclaimer informs readers that ONLY COMMENTARY expressed in this file belongs solely to Ahmed Diab, M.D., and not necessarily to the author’s employer, organization, committee, or other group or individual.

Tracking CBD Effectiveness For Crohn's

One of the most challenging things for people to get used too when first taking CBD is understanding how well it's working for you. Unlike some medications, when it's working well, you won't really notice much of anything. This can definitely make it more challenging for people to nail down if CBD is working for them, or not doing much of anything. Fortunately, Crohn's and Colitis are two conditions that are very easy to track changes with.

The first thing we suggest for anyone who's looking to take CBD is keeping a journal. You'd be surprised how much of a difference this can make in tracking effectiveness. For many, once they start noting how much CBD they've taken in a given day, and how their symptoms faired, it doesn't take long until they feel confident in how effective CBD is for them.

Everyone is different and will have a slightly different reaction to CBD. Some people will notice a difference in the first day, while others may take a few weeks of regular doses before their body really adjusts.

If you're dealing with Crohn's or Colitis, and are thinking about trying CBD to reduce your symptoms, you really ought to start a journal. It can sometimes be harder to notice small trends and details from memory. In fact, most people are only finally able to zero in on the ideal form and dose of CBD by keeping a simple journal.

Anyone who does choose to keep a journal should seriously consider leaving a description of their experience here for others to learn from. All we need is a simple breakdown of your time using CBD, along with a score for how well it improved your inflammation, pain, and cramping. By working together, we can help build a healthier world.

Written By
John Mace Alois is lead content creator at the Did CBD Work? project. He’s analyzed over 400 research papers related to Cannabidiol and helped publish over 55 works related to different conditions for the project. He majored in Cultural Anthropology, with a minor in English, from the University at Albany. He is an avid collector of art supplies and refurbishes old furniture in his spare time.
Reviewed By*
Ahmed Diab, M.D is a graduate of Ain Shams University in Cairo, Egypt. Senior He is currently Senior Medical Writer at NegidaClin. He has written dozens of manuscripts for pharmaceutical enterprises. He published works also included drug safety and efficacy for those with Parkinsons Disease and a historical analysis of the performance of prostheses in femoral neck fractures.

*The information contained here does not constitute medical recommendations. Ahmed Diab does not recommend a certain dosage or a certain indication for any of our products. Please consult your personal physician before using any product.

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