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Depression overview

Feelings of depression are very common and affect most people at one time or another. While they pass relatively quickly most of the time, when it becomes a chronic condition, it can significantly reduce your overall quality of life.

Feelings of intense sadness or worthlessness, which last for many days or months is a sign that you or a loved one may be dealing with clinical depression. Experts agree on several warning signs of clinical depression outside of just the general depression, such as a lack of energy throughout the day, difficulty focusing or remembering, and a lack of pleasure in formerly enjoyed tasks.

Even worse, depression disorders are known to impact almost every aspect of life, and they affect everyone differently. When depression becomes persistent, it causes some people to stop eating and lose weight, while others start overeating and gain weight.

By the same token, depression is known to cause some people to oversleep, while others find it extremely difficult to sleep at all. One thing that’s consistent for everyone dealing with clinical depression is that it can bring the rest of your life to a grinding halt if left untreated.

Depression can be caused by a wide range of factors, many of which are not fully understood yet. For instance, most researchers agree that developing clinical depression is usually associated with a stressful life event, but that doesn’t begin to provide the whole picture.

In fact, research shows a large portion of what leads to persistent depression is genetics and the presence of other mental disorders; Not to mention other important considerations such as personality and substance abuse.

So while many people equate depression to being a simple chemical imbalance in the brain, that only scratches the surface of what’s behind this debilitating condition. It’s not just as simple as having too much, or too little of a given substance, which makes treatment a lot more tricky.

According to research, around 16.2 million Americans deal with chronic depression, or approximately 7% of the population. This makes it the leading cause of disability among people aged 15-44. Statistics also show that while depression can develop at any age, around 32.5 is the average, and it tends to affect more women than men.

If you believe you or a loved one may be dealing with clinical depression, the best thing you can do is talk to a doctor about getting a more clear diagnosis. Professionals will always be able to provide the best answers and treatment options, so talking to a doctor first is always advised. However, let’s take a look at what the independent evidence has to say about depression.

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Table of Contents

CBD Research For Depression

potencial impact research overview

Depression- Endocannabinoid system dysfunction in mood and related disorders

  • University of Newcastle upon Tyne
  • 2011

related conditions:

Depression

Research shows evidence the endocannabinoid system has a significant impact on several mood-related disorders. The team found abnormalities in the CB1 receptor were correlated with increased risk of psychiatric disorders. While more research is required, this study provides a solid foundation for the efficacy of CBD as a treatment for several mood disorders.

Depression- Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa

  • Federal University of Rio de Janeiro
  • 2014

related conditions:

Depression

Study indicates CBD helps with the non-activation of neuroreceptors CB1 and CB2, while also having a good interaction with the 5-HT1A neuro-receptor. The team wanted to understand the potential anxiolytic and antidepressive benefits of CBD better. All of their animal models showed this effect, including forced swimming test (FST), elevated plus maze (EPM), and Vogel conflict test (VCT).

Depression- The endocannabinoid system and the treatment of mood and anxiety disorders

  • The Rockefeller University
  • 2009

related conditions:

Depression

The researchers reviewed all the available evidence on the ability of CBD to treat anxiety and depression disorders. Both clinical and preclinical data agree targeting CBD receptors, such as CB1, is likely a viable option for treating psychological disorders. They also determined abnormalities in the endocannabinoid system increases the risk of these same disorders.

Depression- The endocannabinoid system and the treatment of mood and anxiety disorders

  • The Rockefeller University
  • 2009

related conditions:

Depression

The researchers reviewed all the available evidence on the ability of CBD to treat anxiety and depression disorders. Both clinical and preclinical data agree targeting CBD receptors, such as CB1, is likely a viable option for treating psychological disorders. They also determined abnormalities in the endocannabinoid system increases the risk of these same disorders.

Depression- Endocannabinoid signaling in the etiology and treatment of major depressive illness

  • Medical College of Wisconsin
  • 2014

related conditions:

Depression

Researchers set out to answer distinct questions about the connection between CBD and psychological disorders. This included the idea CBD can work as an antidepressant and whether or not traditional antidepressants activate the CB1R endocannabinoid receptor. The team concluded CBD activates the CB1R receptor, just like antidepressants, and should be considered for clinical trials.

Depression- Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors

  • University of Sao Paulo
  • 2010

related conditions:

Depression

The study concludes the effect of CBD is comparable to that of antidepressants such as imipramine. The team tested the effect of CBD on male Swiss mice during forced swimming test, and in an open field arena. They found that treatment reduced their immobility time in the forced swim test, without altering their behavior in the open field sections, much the same as imipramine does.

Depression- Putative role of endocannabinoid signaling in the etiology of depression and actions of antidepressants

  • University of British Columbia
  • 2011

related conditions:

Depression

This study provides robust evidence that the endocannabinoid system plays a vital role in both the development and treatment of psychological disorders. They identified a growing body of research proving deficits in the endocannabinoid system is related to higher rates of mental disorders, as well as concluding CBD treatment could be sufficient to produce all the behavioral and biochemical effects of traditional medications.

Depression- Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L

  • University of Mississippi
  • 2010

related conditions:

Depression

Evidence suggests higher doses of CBD, around 200mg, provide significant antidepressant-like effects. The team used several standard test types, including the mouse forced swim test and tail suspension test to track the impact of endocannabinoids. Ultimately, they also found other cannabinoids, such as THC and cannabigerol (CBC) also provide a noticeable benefit for those with psychological disorders.

Depression- Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress

  • University of British Columbia
  • 2009

related conditions:

Depression

Researchers wanted to provide the first evidence detailing the effects of stress on peripheral endocannabinoid content in patients dealing with major depression. The team concluded the peripheral endocannabinoid system content is likely both a cause and treatment for debilitating psychological disorders.

Depression- Serum contents of endocannabinoids are correlated with blood pressure in depressed women

  • Medical College of Wisconsin
  • 2012

related conditions:

Depression

Evidence suggests endocannabinoids could play a vital role in the regulation of blood pressure, especially for those dealing with depression or anxiety. The team also noted a distinct relationship between deficits in the endocannabinoid system with depression and cardiovascular risks. Part of the reason for this was attributed to serum contents of the endocannabinoids.

Depression- The therapeutic potential of the endocannabinoid system for the development of a novel class of antidepressants

  • The Rockefeller University
  • 2009

related conditions:

Depression

Several large scale reports have concluded issues with the endocannabinoid system can lead to severe psychological disorders, and supplementation with CBD may mitigate this risk. The team found CBD helps reduce the severity of anxiety and depression symptoms, while simultaneously fighting future bouts with the disorder.

Depression- Antidepressants and changes in concentration of endocannabinoids and N-acylethanolamines in rat brain structures

  • College of Medicum
  • 2014

related conditions:

Depression

Researchers wanted to investigate the growing pile of data, which suggests deficits in the endocannabinoid system are intimately tied with psychological disorders. The team was able to prove that treatment with endocannabinoids, such as CBD, elicits the same response in AEA levels of the hippocampus and dorsal striatum as traditional antidepressants.

CBD Research That Might Be Useful for Symptoms of Depression

potencial impact research overview

Mood Disorders- Acute Effects of a Single, Oral dose of d9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) Administration in Healthy Volunteers

  • University of Barcelona
  • 2012

related conditions:

Mood Disorders

Unlike THC, which was shown to have acute behavioural and physiological effects, CBD was proven safe and well tolerated by healthy patients. In fact, while THC was associated with higher risks of anxiety and dysphoria, there were no differences between the CBD and placebo on any negative symptomatic variable.

Sleep - Cannabis, Cannabinoids, and Sleep: a Review of the Literature

  • Palo Alto University, CA, USA
  • 2017

related conditions:

Sleep

This report concludes CBD holds promise for significantly increasing the quality of REM sleep. Researchers believe it could one day be a primary force behind improved overall sleep quality. CBD was even shown to reduce daytime sleepiness in many patients.

Anxiety - Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence

  • University of Melbourne, Australia
  • 2013

related conditions:

Anxiety

A comprehensive review of all the plant-based medicine which has had both preclinical and human clinical trials conducted about their anxiolytic-like effect. An analysis of over 1500 papers identified 21 plants which had been adequately tested, with one of the most successful of these plants found to be CBD enriched Cannabis species.

Depression & CBD Research Overview

It’s been incredible to see so many people able to significantly improve their quality of life thanks to an all-natural remedy like CBD. Especially for those dealing with depression, CBD has proven to be a true god-send.

Unlike many of the other conditions which CBD is shown to help improve, depression appears to be even more intimately tied with CBD and the endocannabinoid system. In fact, there’s a growing pile of evidence which says deficits in the endocannabinoid system are directly related with increased risk of psychological disorders such as depression.

One report, called Endocannabinoid signaling in the etiology and treatment of major depressive illness, looked into the connection between the endocannabinoid system and psychological disorders. The researchers found CBD works as an antidepressant by interacting with the same receptors traditional antidepressants do.

Other reports have made similar conclusions, including Putative role of endocannabinoid signaling in the etiology of depression and actions of antidepressants. That study provided robust evidence that the endocannabinoid system is a crucial factor in the development of, but also the treatment for disorders such as chronic depression. According to a study called, Circulating endocannabinoids and N-acyl ethanolamines are differentially regulated in major depression and following exposure to social stress, This effect was shown to be particularly strong for those dealing with major depression.

CBD may also help mitigate the number of bouts with depression according to a study called, The therapeutic potential of the endocannabinoid system for the development of a novel class of antidepressants. That study not only showed CBD is an effective treatment for depression symptoms, but it could also lower your overall risk of further complications.

It’s no wonder CBD has been viewed as a potential treatment for depression given how many studies prove the intimate connection between problems with the endocannabinoid system and chances of depression. One study, called Antidepressants and changes in concentration of endocannabinoids and N-acylethanolamines in rat brain structures, was even able to show the body’s response to CBD in the hippocampus and dorsal striatum is nearly identical to antidepressants.

One of the most common issues that goes along with depression is a general sense of misery and discomfort. For this reason, mood-elevating and stabilizing drugs are part of an effective treatment plan for many types of depression. A study called Endocannabinoid system dysfunction in mood and related disorders showed that activation of the endocannabinoid system has a positive impact on several mood-related disorders, particularly depression.

Research looking into this system, called Antidepressant-like effect of delta9-tetrahydrocannabinol and other cannabinoids isolated from Cannabis sativa L, found cannabinoids such as CBD and cannabigerol (CBC) provide a noticeable benefit to those struggling with mood disorders. The team observed that around 200mg of CBD ensured a significant antidepressant-like effect during all tests.

One of the most exciting and potentially important things about CBD as a treatment for depression is the noted lack of side-effects. In fact, a study called Acute Effects of a Single, Oral dose of d9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) Administration in Healthy Volunteers found that while THC has acute negative behavioral and physiological effects, CBD doesn't. They even went as far as to say there were virtually no differences in the side-effects for the CBD and placebo groups.

Another less discussed factor which has a significant impact on quality of life, especially those dealing with depression, is quality sleep. This makes the fact over, and under, sleeping are common symptoms of depression all the more troublesome. Luckily, research called Cannabis, Cannabinoids, and Sleep: a Review of the Literature has provided ample evidence that CBD can significantly increase the quality of REM sleep, as well as reduce daytime sleepiness.

High blood pressure can sometimes be associated with depression and anxiety. A study called, Serum contents of endocannabinoids are correlated with blood pressure in depressed women, concluded CBD could help regulate blood pressure, especially for those with depression or anxiety issues.

Another major chronic issue which often goes hand-in-hand with depression is anxiety. Luckily, CBD is an extremely effective treatment for this issue as well. A comprehensive review of the available research, called Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence, analyzed over 1500 papers on plant-based medication for anxiety and determined CBD to be among the very best.

More specific studies looking into the effect of CBD on treating depression-related anxiety have also provided some compelling results. An animal model report called, Antidepressant-like and anxiolytic-like effects of cannabidiol: a chemical compound of Cannabis sativa, showed that CBD helps alleviate the non-activation of receptors CB1 and CB2, which often coincides with depression.

Other studies on animal models have reached similar conclusions. An article entitled, Antidepressant-like effects of cannabidiol in mice: possible involvement of 5-HT1A receptors, concluded the effect of CBD is most comparable with that of the common antidepressant, imipramine.

However, we have more than just animal tests which indicate the specific value of CBD for treating depression. In fact, a massive report called, The endocannabinoid system and the treatment of mood and anxiety disorders, reviewed all the human clinical and preclinical data we have on CBD. The researchers determined CBD should be studied further as a viable option for treating CB1-related conditions, such as depression and anxiety.

Best CBD for Depression

NoteCBD Capsules (10mg)

NoteCBD Capsules (10mg)

description

Enjoy the benefits of hemp extract with the convenience of a capsule. Each capsule contains a pre-portioned dose of full-spectrum hemp extract and MCT oil.

$45.00
  • CBD Per Serving: 10mg
  • Number Of Servings: 30
  • Cost Per Serving: $1.50
  • Cost Per/mg of CBD: $0.15
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advantages

  • Full Spectrum
  • Lab Certified
  • Organic
  Servings per day Days supplied in one package Cost per week
Low Dosage (12 mg/day) 1.20 25.0 $12.60
Mid Dosage (30 mg/day) 3.00 10.0 $31.50
High Dosage (50 mg/day) 5.00 6.0 $52.50

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Pure CBD Oil Capsules (15mg)

Pure CBD Oil Capsules (15mg)

description

Every Day Optimal Soft Gel PCR Hemp Oil Capsule contains 15mg pure CBD from our proprietary high CBD strain of hemp.

$59.99
  • CBD Per Serving: 15mg
  • Number Of Servings: 30
  • Cost Per Serving: $2.00
  • Cost Per/mg of CBD: $0.13
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advantages

  • Easy Capsule Form
  • No GMO
  • All Natural
  Servings per day Days supplied in one package Cost per week
Low Dosage (12 mg/day) 0.80 37.5 $11.20
Mid Dosage (30 mg/day) 2.00 15.0 $28.00
High Dosage (50 mg/day) 3.33 9.0 $46.66

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NoteCBD Capsules (25mg)

NoteCBD Capsules (25mg)

description

Enjoy the benefits of hemp extract with the convenience of a capsule. Each capsule contains a pre-portioned dose of full-spectrum hemp extract and MCT oil.

$95.00
  • CBD Per Serving: 25mg
  • Number Of Servings: 30
  • Cost Per Serving: $3.17
  • Cost Per/mg of CBD: $0.13
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advantages

  • Full Spectrum
  • Gluten Free
  • Lab Certified
  Servings per day Days supplied in one package Cost per week
Low Dosage (12 mg/day) 0.48 62.5 $10.64
Mid Dosage (30 mg/day) 1.20 25.0 $26.60
High Dosage (50 mg/day) 2.00 15.0 $44.33

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Suggested CBD Dosage for Depression

Dosage Per Day

Low

12 mg

Mid

30 mg

High

50 mg

If there’s one question we get more often than how to track the effectiveness of CBD, it’s how much should they take for a given condition. While it would be ideal to have an exact answer for each disease, the truth is that things are much more complicated on a person-by-person level.

Most people have been able to find their ideal dosages with relative ease, simply by trying different combinations until they found a happy medium. One thing that makes this much easier is that CBD isn’t psychoactive, and therefore doesn’t get you high.

However, just because there isn’t a precise answer for everyone, doesn’t mean we can’t give you a solid starting point for treating your depression. According to an article on Medium.com, when treating depression with CBD, it’s often best to take smaller doses, around 5-10mg, every couple of hours. This is a decent starting point, but depending on your lifestyle and how it fits, you may end up finding something much different that works better.

It’s also very important to keep in mind that while CBD has become extremely popular and common in many places, it’s still technically illegal in some parts of the country. That’s why it’s vital you check local laws before making an online purchase.

We also want to mention that while most CBD products don’t contain any THC, there is a large selection of those which still have THC present. This is mostly because the combination of THC and CBD has been shown to be particularly effective in some stubborn cases of depression and anxiety. Just make sure always to double-check your products before you buy if you can’t or don’t want to get high.

Whatever type of CBD product you end up with, you should really consider keeping track of your progress in a journal. It can make a huge difference in how long it takes to hone in on the proper dosages.

Tracking CBD Effectiveness For Depression

One of the most common questions we get is how to tell if CBD is working for you. It can be a tricky question, as it’s slightly different for everyone. Not only that but depending on which condition you’re talking about it can be a very subtle change.

Depression falls somewhere in the middle of those two extremes. It’s a bit nuanced to keep track of, but overall, you likely have a good idea of how you feel on a day-by-day basis. We always suggest starting a daily journal to keep track of your dosages and symptoms for the day.

Anytime you’re introducing a new substance to your body on a daily basis, it takes a little while for things to get acclimated. That’s where keeping a journal can really come in handy, as it’ll allow you to easily go back and notice patterns you may have missed.

In fact, another reason this system is so valuable for depression is the range of depression-related symptoms CBD is known to treat, such as anxiety and stress. While many people think of keeping a journal as unnecessary, you’ll be surprised to see how much more clarity it can offer.

Regardless of how you decide to track your progress with CBD, we hope you choose to leave your experiences here for the next person to learn from. While it only takes a couple of minutes of your time, it could be a life-changing message for someone in dire need.

All you have to do is leave a short description of your time using CBD, along with individual scores for how well it improved your overall mood, anxiety, and stress. If we work together, we can help spread to benefits of CBD to everyone who needs to hear about it.

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