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Huntington's Disease overview

Huntington’s disease is an inherited disease that is characterized by the progressive breakdown of brain cells. This disorder has a wide range of effects that continually deteriorate a patient’s ability to move and process information until it becomes fatal in typically between 10 to 30 years.

The majority of people who develop Huntington’s begin to notice symptoms at some point in their 30s or 40s. That said, it’s possible to develop the condition earlier or later, which can result in a slightly different set of symptoms and rate of progression. Medications may help control the symptoms of Huntington’s, but sadly there is no known cure for this terminal illness

Huntington’s manifests in a wide variety of ways, resulting in many movement and cognitive/psychiatric disorders. Which symptoms appear first will vary from person to person. Likewise, some of the developed disorders will be dominant and have a larger impact on overall function than others.

The movement issues associated with Huntington’s tend to include things such as involuntary jerking movements, muscle rigidity, difficulty walking, or difficulty speaking. The cognitive problems, on the other hand, include difficulty focusing, difficulty adapting to change, loss of impulse control and self-awareness, as well as trouble learning new information.

The neurological impact of Huntington’s can also manifest in psychiatric disorders. The most common is depression, but researchers don’t believe this is purely a reaction to the diagnosis itself. Rather, depression for Huntington’s patients seems to be, in part, a result of specific brain injury and the resultant changes. Other psychiatric disorders that have been known to develop include OCD, Mania, as well as Bipolar Disorder.

Huntington’s is caused by an inherited defect in a single gene. Notably, as an autosomal dominant disorder, only one parent needs to pass it on for the child to be at risk, although the risk isn’t as high.

Preventing Huntington’s is something that is incredibly difficult, and only possible with a trusted doctor and careful planning. Potential parents with a family history of Huntington’s can consider getting tested for the gene. However, thanks to modern medicine, it is possible to utilize in vitro fertilization and a process known as preimplantation genetic diagnosis to prevent passing on the affected gene.

Huntington’s disease affects around 30,000 people across the United States at any given time. However, an additional 150,000 are living with the gene and are at risk of developing Huntington’s at some point.

Given that Huntington’s is a terminal condition, the main priority of most medications is limiting the impact of symptoms on quality of life. If you’re worried that you or a loved one may be developing Huntington’s, be sure to talk to your doctor as soon as possible. Only a trusted medical professional can diagnose the condition, as well as provide an adequate treatment plan.

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Table of Contents

CBD Research For Huntington's Disease

potencial impact research overview

Huntington's - Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington’s disease

  • Complutense University
  • 2011

related conditions:

Huntington’s Disease

This study sought to understand if cannabinoids provided neuroprotection to those suffering from Huntington’s disease. Using rat models, subjects were given extracts containing a 1:1 ratio of both THC and CBD. Researchers concluded their study provided preclinical evidence on the potential neuroprotective properties of cannabinoids, with the potential to delay the progression of Huntington’s Disease.

Huntington's - Cannabinoids: Novel medicines for the treatment of Huntington’s disease

  • Complutense University
  • 2006

related conditions:

Huntington’s Disease

This review highlights the potential of CBD-containing medicines provides to those suffering from a myriad of conditions, such as Huntington’s Disease. Authors note the rise of cannabinoid pharmacology, as well as the rise of cannabis-based medicines such as Cesamet, Marinol, and Sativex. The authors concluded that based on current data, cannabinoids might hold potential as a disease-modifying agent for those currently living with Huntington’s disease.

Huntington's - Sativex-like combination of phytocannabinoids is neuroprotective in malonate-lesioned rats, an inflammatory model of Huntington's disease: role of CB1 and CB2 receptors

  • Complutense University
  • 2012

related conditions:

Huntington’s Disease

This study investigates whether a 1:1 combination of CBD and THC is neuroprotective in Huntington’s disease. By using an experimental model, researchers demonstrated that endocannabinoid system antagonists are effective in delaying damage caused by neurodegenerative diseases. Researchers concluded that cannabis-based medicines might provide beneficial neuroprotective benefits to those suffering from degenerative conditions such as Huntington’s disease.

Huntington's - Neuroprotective properties of cannabigerol in Huntington's disease: studies in R6/2 mice and 3-nitropropionate-lesioned mice

  • Complutense University
  • 2015

related conditions:

Huntington’s Disease

Researchers wanted to demonstrate the neuroprotective properties of cannabinoids using two different in vivo models of Huntington’s disease. Researchers found cannabinoids, such as CBG and CBD, were remarkably active as a neuroprotectant in rat models, both preserving striatal neurons and improving motor deficits. The team ultimately concluded their results opened new research avenues for the use of CBG for the treatment of neurodegenerative diseases such as Huntington’s.

Huntington's - Controlled clinical trial of cannabidiol in Huntington's disease

  • University of Arizona
  • 1991

related conditions:

Huntington’s Disease

This trial sought to evaluate the symptomatic efficacy and safety of CBD for treating patients with Huntington’s disease. In a double-blind, randomized study, researchers compared the effectiveness of 10 mg/kg/day of CBD compared against a placebo on their effects on chorea safety and other therapeutic variables. Researchers ultimately did not find notable symptomatic benefits of CBD use, although noted the overall safety and lack of side-effects associated with CBD treatment.

Huntington's - Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress

  • University of Mississippi
  • 2011

related conditions:

Huntington’s Disease

In this review, researchers sought to demonstrate the efficacy of using CBD to treat a variety of diseases and disorders related to immune system activation and oxidative stress. The authors note the role oxidative stress plays in immune response and wanted to understand the role of the endocannabinoid system may play in treating such conditions. In conclusion, the authors found that CBD may hold promise as a prototype for anti-inflammatory drug development.

CBD Research That Might Be Useful for Symptoms of Huntington's Disease

potencial impact research overview

Mood Disorders- Acute Effects of a Single, Oral dose of d9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) Administration in Healthy Volunteers

  • University of Barcelona
  • 2012

related conditions:

Mood Disorders

Unlike THC, which was shown to have acute behavioural and physiological effects, CBD was proven safe and well tolerated by healthy patients. In fact, while THC was associated with higher risks of anxiety and dysphoria, there were no differences between the CBD and placebo on any negative symptomatic variable.

Sleep - Cannabis, Cannabinoids, and Sleep: a Review of the Literature

  • Palo Alto University, CA, USA
  • 2017

related conditions:

Sleep

This report concludes CBD holds promise for significantly increasing the quality of REM sleep. Researchers believe it could one day be a primary force behind improved overall sleep quality. CBD was even shown to reduce daytime sleepiness in many patients.

Anxiety - Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence

  • University of Melbourne, Australia
  • 2013

related conditions:

Anxiety

A comprehensive review of all the plant-based medicine which has had both preclinical and human clinical trials conducted about their anxiolytic-like effect. An analysis of over 1500 papers identified 21 plants which had been adequately tested, with one of the most successful of these plants found to be CBD enriched Cannabis species.

Huntington's Disease & CBD Research Overview

CBD has rapidly grown into a massive industry thanks to a growing body of peer-reviewed evidence highlighting the many benefits. While we still have a whole lot to learn about the effects of CBD on various conditions, the last 15 years of research has offered some incredible insight.

Researchers have been wondering if CBD can offer any benefits for those living with Huntington's for a long time now. In fact, older research dating back to the early 90s looked into this very question. For instance, Controlled clinical trial of cannabidiol in Huntington's disease conducted a double-blind trial looking into what CBD can do for Huntington's patients. While these early reports didn't find much evidence into any benefit, they did note what is now a commonly referenced benefit of CBD, that it's extremely well tolerated by humans, even in high dosages.

Some reports have focused on whether or not CBD can slow the progression of neurodegenerative disorders such as Huntington's. A study called Sativex-like combination of phytocannabinoids is neuroprotective in malonate-lesioned rats, an inflammatory model of Huntington's disease: role of CB1 and CB2 receptors used an experimental model to show that endocannabinoid antagonists, such as CBD, delay the damage caused by these disorders.

As more research has been conducted, we've uncovered some clear ways CBD can slow the progression of Huntington's disease. A 2011 report called, Neuroprotective effects of phytocannabinoid-based medicines in experimental models of Huntington's disease wanted to determine if cannabinoids provide any neuroprotective effect for those living with Huntington's. The team concluded that not only can CBD slow progression of Huntington's, but it may also offer powerful relief from some of its symptoms.

This symptomatic relief has been shown by studies like Cannabinoids: Novel medicines for the treatment of Huntington's disease, which indicated CBD could be a disease-modifying agent for neurodegenerative disorders such as Huntington's. They noted the rise of several cannabis-based medications, which are currently known to have a powerful effect on complex neurological abnormalities.

A study of in vivo models of Huntington's such as Neuroprotective properties of cannabigerol in Huntington's disease: studies in R6/2 mice and 3-nitropropionate-lesioned mice, showed a dramatic neuroprotective effect thanks to interaction by various cannabinoids. The team believed their data provides the needed foundation for further study into how cannabinoids such as CBG and CBD affect the multiple symptoms of complex disorders like Huntington's.

A review of the available research, called Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress, indicated CBD could treat a wide range of disorders related to the immune system. They believe CBD can regulate oxidative stress, as well as general inflammation, associated with Huntington's.

One of the most common symptoms throughout the course of Huntington's is impulse control problems and mood swings. However, CBD has been shown by researchers to have a substantial impact on regulating behavior. A study called Acute Effects of a Single, Oral dose of d9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) Administration in Healthy Volunteers showed that while THC may increase anxiety and dysphoria, CBD doesn't have any of the negative side effects, while still offering some important benefits.

Restlessness and trouble sleeping are another set of common problems that often happen alongside the development of Huntington's disease. Many patients report difficulty staying asleep throughout the night, but CBD may be able to help those people. According to reports such as Cannabis, Cannabinoids, and Sleep: a Review of the Literature, CBD may be a powerful tool in improving the quality of REM. In fact, they believe it could one day be one of the go-to remedies we have.

Finally, Huntington's often leads to increased levels of anxiety. While this is perfectly understandable, it doesn't make it any less detrimental to daily life. Luckily, CBD has long been known to provide some powerful anti-anxiety benefits. A report entitled, Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence, analyzed over 1500 papers on plant-based anxiety meds before concluding CBD is the most effective.

Best CBD for Huntington's Disease

Everyday Optimal CBD Capsules (200mg)

Everyday Optimal CBD Capsules (200mg)

description

Are you looking for something stronger than almost any CBD oil product on the market? Then you’ll love the newest addition to our high potency CBD line. With each capsule containing 200mg of pure CBD, you’ll experience all-natural, long-lasting relief for tough pain, sleep problems, anxiety, and more.

$299.99
  • CBD Per Serving: 200mg
  • Number Of Servings: 30
  • Cost Per Serving: $10.00
  • Cost Per/mg of CBD: $0.05
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advantages

  • Highest Capsule In USA
  • 100% USA Made
  • THC Free
  Servings per day Days supplied in one package Cost per week
Low Dosage (15 mg/day) 0.08 400.0 $5.25
Mid Dosage (40 mg/day) 0.20 150.0 $14.00
High Dosage (100 mg/day) 0.50 60.0 $35.00

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Pure CBD Oil Capsules, (50mg)

Pure CBD Oil Capsules, (50mg)

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Every Day Optimal Soft Gel PCR Hemp Oil Capsule contains 50mg of pure CBD.

$119.99
  • CBD Per Serving: 50mg
  • Number Of Servings: 30
  • Cost Per Serving: $4.00
  • Cost Per/mg of CBD: $0.08
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  • Easy Capsule Form
  • All Natural
  • GMP Compliant
  Servings per day Days supplied in one package Cost per week
Low Dosage (15 mg/day) 0.30 100.0 $8.40
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High Dosage (100 mg/day) 2.00 15.0 $56.00

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Relax Full Spectrum CBD Oil (3500mg)

Relax Full Spectrum CBD Oil (3500mg)

description

Relax Full Spectrum CBD Oil, available with an oil tincture dropper, delivers the ideal amount of CBD to meet all of your wellness needs. Made in the USA  from 100% high quality industrial hemp, this 3500 mg bottle of CBD is perfect for those wanting to combat stress, anxiety, and chronic pain.

$168.00
  • CBD Per Serving: 116.67mg
  • Number Of Servings: 30
  • Cost Per Serving: $5.60
  • Cost Per/mg of CBD: $0.05
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  • 100% Hemp Product
  • Made in USA
  • Full Spectrum
  Servings per day Days supplied in one package Cost per week
Low Dosage (15 mg/day) 0.13 233.3 $5.04
Mid Dosage (40 mg/day) 0.34 87.5 $13.44
High Dosage (100 mg/day) 0.86 35.0 $33.60

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Suggested CBD Dosage for Huntington's Disease

Dosage Per Day

Low

15 mg

Mid

40 mg

High

100 mg

The most common question we ever field has got to be exactly how much CBD is needed to treat symptoms related to various conditions, including Huntington’s. While we wish we could just provide the perfect answer for each condition, the truth is many variables come into play, and finding the right routine will require testing.

That said, we can offer some tips for when you’re just starting out on CBD. In general, it’s best to start with lower doses, 25-50mg, and working your way up over time. According to anecdotal reports, daily treatment with CBD oil has been provided some critical benefits for those living with Huntington’s.

We always try to mention that while CBD has become a widespread product across the country, this isn’t true everywhere. In fact, many places still look at CBD as basically the same thing as THC. That means you must exercise some real diligence when taking CBD on your travels. Always do the research first.

We should also mention that while a lot of CBD products will be THC-free, this isn’t the case for all of them. This is mainly because some people find extra benefit from taking CBD products, which still offer a bit of bolstering THC. So if you’re unwilling or unable to get high, you need to make sure to buy CBD-only products.

No matter which way you decide to move forward with CBD, we hope you choose to leave what you’ve learned here for others to learn from. Lack of trustworthy information can be a big challenge for those who are just starting with CBD, so anything you can offer is a big help. The more we work together, the more well-informed we can make the world.

Tracking CBD Effectiveness For Huntington's Disease

Something hard for people who are just starting on CBD to get a handle on is exactly how well it’s working for them. This is a very frustrating problem for many, but that doesn’t mean you’re alone. In fact, most people face this issue since CBD has such a subtle effect. When it comes to conditions such as Huntington’s, anything that can improve the quality of life is a priority.

We suggest anyone starting a regimen of CBD to keep a simple journal for tracking their progress. All it takes is recording your daily dose and subsequent symptoms. People who do this for a few weeks are amazed by how much clearer the question of “did CBD work for me” becomes.

Each person is slightly different and will require a somewhat different ideal routine. Some people may find success after only a week, while for others, it could take some serious experimentation before they feel comfortable calling it one way or another. The main thing to do is to pay attention to your body.

We’re often asked if keeping a journal is a vital part of success with CBD. While it’s true that many people have found success only taking CBD and not tracking their progress, nothing will increase your chances of achieving your goals than a simple journal.

Anyone who does choose to track their progress should seriously consider leaving a brief overview of that experience here for newcomers to learn from. All it takes is a couple of minutes to provide your expertise along with a score for how well it improved your anxiety, trouble sleeping, and mood swings. By working together, we can help provide as much relief as possible to those dealing with Huntington’s disease.

Experiences Using CBD for Huntington's Disease

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