Does CBD Work For Inflammation

According to the report, there is growing reason to believe CBD plays a positive role in treating several human diseases and disorders now known to involve activation of the immune system and associated oxidative stress. It could play a significant role in treating severe conditions such as types 1 and 2 diabetes, rheumatoid arthritis, Alzheimer disease, neuropathic pain, and even depression.

A review of the available information concluded CBD has valuable analgesic and anti-inflammatory effects. Researchers believe CBD should, therefore, be seen as a legitimate alternative to over the counter drugs. The evidence also showed that CBD significantly reduces the anxiety induced by another cannabinoid, THC, and should be studied further.

The team wanted to study the impact of CBD on cisplatin-induced nephropathy, especially given CBD has recently been approved for the treatment of chronic pain and inflammation. Research indicated pretreatment with CBD significantly decreases oxidative stress, inflammation, as well as cell death in the kidney, all while improving overall renal function. CBD should now be seen as a promising new way to protect against cisplatin-induced nephrotoxicity.

Researchers wanted to determine if stimulating different cannabinoid receptor types (CB1, CB2, and TRPV1) has an impact on their effectiveness. Ultimately, they concluded neither CB1 or CB2 had much of an effect on the overall effect, but the TRPV1 receptor is a strong candidate for the molecular target of CBD’s antihyperalgesic effect.

Research shows that CBD provides significant benefits to chronic inflammation and pain. The team took particular interest in the effect of CBD on high glucose-induced mitochondrial superoxide generation, as well as a host of other specific functions. The high glucose-induction alone provided significant benefits across the board. However, the researchers showed their benefits were all significantly improved by CBD pretreatment.

The team wanted to explore whether or not CBD effects are subordinate to its activity at peroxisome proliferator-activated receptor-γ. Their analysis showed a blockade of PPARy significantly blunt the impact of CBD on neuronal inflammation, highlighting the importance of their relationship. Perhaps even more impressively, CBD was shown to promote hippocampal neurogenesis.

Researchers concluded CBD is an effective treatment for vascular-neuroinflammation. Particular focus was placed on the novel mechanisms which interact with CBD according to animal models. These included protection against both neuroinflammation and neurodegeneration via a positive interaction with nucleoside transporters.

CBD was shown to significantly reduce the expression of S100B and iNOS proteins in human biopsies. These findings confirmed similar results which have been noted in lab mice. Researchers concluded CBD is indeed a viable new strategy for treating a wide range of inflammatory conditions.

Researchers wanted to better understand the connection between CBD and pain management via glycine receptors. According to their study of mice, a regimen of CBD can dramatically lower chronic pain and inflammation. Interestingly, it was shown to provide this value without causing increased tolerance or a need for higher dosages.

CBD was shown to have “potent immunosuppressive and anti-inflammatory properties.” Their testing was able to confirm that CBD still provides valuable anti-inflammatory value even during acute lung injury. The researchers believe this is most likely due to an increase in the extracellular adenosine which sends signals via the A(2A) receptor.

A comprehensive review of research looked into the anti-inflammatory effects of different cannabinoids, including CBD. The team set out to provide an overview of everything we know about the connection between cannabinoids and inflammation. Their analysis showed CBD doesn’t suppress eicosanoids production as many anti-inflammatory medications do. In fact, CBD was shown to increase production while still providing inflammation relief.

A study of mice concluded CBD has significant anti-inflammatory effects. The researchers also saw evidence that the expression of the GPR55 receptor was improved after starting on CBD. Treatment with CBD was shown to significantly decrease the levels of several inflammation-related chemicals in test subjects.

Researchers conducted a review of the available information on the connection between CBD and inflammation. They found plenty of evidence suggesting the endocannabinoid system is intimately complicated and connected with key processes related to inflammation. There is plenty of reason to be optimistic about CBD’s anti-inflammatory properties, but more research is needed to confirm according to the team.

CBD was shown to have “analgesic, immunomodulatory and anti‐inflammatory properties.” Researchers determined a CBD regimen reduces joint damage from arthritis, mainly by strengthening cartilage. They also noted several different ways in which the body reacts favorably to the introduction of CBD, especially in mitigating the degradation and inflammation induced by cytokines.

Researchers concluded CBD significantly reduces discomfort and pain, in part, due to the interaction between two substances, PEA and anandamide. According to tests, they “act synergistically, reducing pain responses 100-fold more potently than each compound alone”.

A human study of Sativex showed significant benefits for patients dealing with Multiple Sclerosis. In fact, it was more effective than one of the most common treatments for MS-related spasticity, baclofen. So much so, they suggested CBD based drugs like Sativex become the primary tool for fighting stiffness related to MS.