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Inflammation overview

Published on July 16th, 2019

Last updated on May 26th, 2020

While most people think of inflammation as a bad thing, the truth is it’s a vital process that our T helper cells (Th) use in producing inflammatory cytokines and macrophages, which helps to protect us from infections. However, problems with inflammation tend to arise from autoimmune diseases. These conditions cause our immune system to trigger an inflammatory response when there are no bacteria or viruses present, which in turn causes damage to our bodies instead.

When any inflammation occurs, chemicals are released into affected tissues, which dramatically increase blood flow. Some of these chemicals essentially cause a leak of fluid into the affected part of the body, which results in sometimes painful swelling. Most people think of inflammation and swelling as the same thing, but the truth is that swelling is just one symptom of inflammation.

People dealing with acute inflammation may sometimes experience redness or joint pain and stiffness in affected parts of the body, and this is particularly true of arthritis. Sometimes, people even report flu-like symptoms with their inflammation, including fever, chills, fatigue, and headaches. For example, osteoarthritis of the hand (HOA), which is more severe than non-erosive HOA, affects the interphalangeal joints, causing pain and sometimes functional impairment. In this case, the inflammatory symptoms include stiffness, soft tissue swelling, and pain. It is important to note that inflammation is a complicated condition as there exist two main types, and each can affect different parts of the body.

For instance, while most people associate inflammation with pain, many forms of inflammation affect internal organs, which lack pain-sensing nerves. Other factors will have a significant impact on how likely you are to experience an unintended inflammatory response, such as your age, weight, diet, and life habits.

Young people are less likely to have inflammation than the elderly, and the heavier you are, the higher your risk. However, less obvious risk factors like smoking, poor diet, or even low sex drive can all be risk factors for chronic inflammation. It is estimated that 43 million people in the United States, and 350 million worldwide, suffer from arthritis and joint diseases.

Inflammation is already a widespread issue, but the number of cases is expected to top 60 million by the end of next year. If you or a loved one thinks they’re dealing with chronic inflammation, be sure to talk to your doctor as soon as possible. The only way to know for sure what you’re dealing with is to get the proper tests along with providing an adequate patient history.

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Table of Contents

CBD Research For Inflammation

potencial impact research overview

Inflammation - Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress

  • Department of Pharmacology and Toxicology, School of Medicine, and Center for Excellence in Cardiovascular-Renal Research, University of Mississippi Medical Center, Jackson, USA
  • 2011

related conditions:

Inflammation

According to the report, there is growing reason to believe CBD plays a positive role in treating several human diseases and disorders now known to involve activation of the immune system and associated oxidative stress. It could play a significant role in treating severe conditions such as types 1 and 2 diabetes, rheumatoid arthritis, Alzheimer disease, neuropathic pain, and even depression.

Inflammation - Cannabinoids in clinical practice

  • The School of Pharmacy
  • 2000

related conditions:

Inflammation

A review of the available information concluded CBD has valuable analgesic and anti-inflammatory effects. Researchers believe CBD should, therefore, be seen as a legitimate alternative to over the counter drugs. The evidence also showed that CBD significantly reduces the anxiety induced by another cannabinoid, THC, and should be studied further.

Inflammation - Cannabidiol attenuates cisplatin-induced nephrotoxicity by decreasing oxidative/nitrosative stress, inflammation, and cell death

  • Zhejiang University
  • 2009

related conditions:

InflammationJoint PainKidney Disease

The team wanted to study the impact of CBD on cisplatin-induced nephropathy, especially given CBD has recently been approved for the treatment of chronic pain and inflammation. Research indicated pretreatment with CBD significantly decreases oxidative stress, inflammation, as well as cell death in the kidney, all while improving overall renal function. CBD should now be seen as a promising new way to protect against cisplatin-induced nephrotoxicity.

Inflammation - Vanilloid TRPV1 receptor mediates the antihyperalgesic effect of the nonpsychoactive cannabinoid, cannabidiol, in a rat model of acute inflammation

  • University of Milan-Bicocca
  • 2004

related conditions:

Inflammation

Researchers wanted to determine if stimulating different cannabinoid receptor types (CB1, CB2, and TRPV1) has an impact on their effectiveness. Ultimately, they concluded neither CB1 or CB2 had much of an effect on the overall effect, but the TRPV1 receptor is a strong candidate for the molecular target of CBD’s antihyperalgesic effect.

Inflammation - Cannabidiol attenuates high glucose-induced endothelial cell inflammatory response and barrier disruption

  • National Institutes of Health/NIAAA
  • 2007

related conditions:

Inflammation

Research shows that CBD provides significant benefits to chronic inflammation and pain. The team took particular interest in the effect of CBD on high glucose-induced mitochondrial superoxide generation, as well as a host of other specific functions. The high glucose-induction alone provided significant benefits across the board. However, the researchers showed their benefits were all significantly improved by CBD pretreatment.

Inflammation - Cannabidiol reduces Aβ-induced neuroinflammation and promotes hippocampal neurogenesis through PPARγ involvement

  • Sapienza University of Rome
  • 2011

related conditions:

Inflammation

The team wanted to explore whether or not CBD effects are subordinate to its activity at peroxisome proliferator-activated receptor-γ. Their analysis showed a blockade of PPARy significantly blunt the impact of CBD on neuronal inflammation, highlighting the importance of their relationship. Perhaps even more impressively, CBD was shown to promote hippocampal neurogenesis.

Inflammation - Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation

  • Medical College of Georgia
  • 2010

related conditions:

Inflammation

Researchers concluded CBD is an effective treatment for vascular-neuroinflammation. Particular focus was placed on the novel mechanisms which interact with CBD according to animal models. These included protection against both neuroinflammation and neurodegeneration via a positive interaction with nucleoside transporters.

Inflammation - Cannabidiol reduces intestinal inflammation through the control of neuroimmune axis

  • University of Naples
  • 2011

related conditions:

Inflammation

CBD was shown to significantly reduce the expression of S100B and iNOS proteins in human biopsies. These findings confirmed similar results which have been noted in lab mice. Researchers concluded CBD is indeed a viable new strategy for treating a wide range of inflammatory conditions.

Inflammation - Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors

  • National Institutes of Health
  • 2012

related conditions:

Inflammation

Researchers wanted to better understand the connection between CBD and pain management via glycine receptors. According to their study of mice, a regimen of CBD can dramatically lower chronic pain and inflammation. Interestingly, it was shown to provide this value without causing increased tolerance or a need for higher dosages.

Inflammation - Cannabidiol, a non-psychotropic plant-derived cannabinoid, decreases inflammation in a murine model of acute lung injury: role for the adenosine A(2A) receptor

  • University of São Paulo
  • 2012

related conditions:

Inflammation

CBD was shown to have “potent immunosuppressive and anti-inflammatory properties.” Their testing was able to confirm that CBD still provides valuable anti-inflammatory value even during acute lung injury. The researchers believe this is most likely due to an increase in the extracellular adenosine which sends signals via the A(2A) receptor.

Inflammation - Cannabinoids, endocannabinoids, and related analogs in inflammation

  • University of Massachusetts Medical School
  • 2009

related conditions:

Inflammation

A comprehensive review of research looked into the anti-inflammatory effects of different cannabinoids, including CBD. The team set out to provide an overview of everything we know about the connection between cannabinoids and inflammation. Their analysis showed CBD doesn’t suppress eicosanoids production as many anti-inflammatory medications do. In fact, CBD was shown to increase production while still providing inflammation relief.

Inflammation - Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice

  • Tongji University School of Medicine
  • 2013

related conditions:

Inflammation

A study of mice concluded CBD has significant anti-inflammatory effects. The researchers also saw evidence that the expression of the GPR55 receptor was improved after starting on CBD. Treatment with CBD was shown to significantly decrease the levels of several inflammation-related chemicals in test subjects.

Inflammation - The endocannabinoid system: an emerging key player in inflammation

  • Wageningen University
  • 2014

related conditions:

Inflammation

Researchers conducted a review of the available information on the connection between CBD and inflammation. They found plenty of evidence suggesting the endocannabinoid system is intimately complicated and connected with key processes related to inflammation. There is plenty of reason to be optimistic about CBD’s anti-inflammatory properties, but more research is needed to confirm according to the team.

CBD Research That Might Be Useful for Symptoms of Inflammation

potencial impact research overview

Arthritis - Arthritis and cannabinoids: HU‐210 and Win‐55,212–2 prevent IL‐1 α‐induced matrix degradation in bovine articular chondrocytes in‐vitro

  • Royal Pharmaceutical Society of Great Britain
  • 2006

related conditions:

Arthritis

CBD was shown to have “analgesic, immunomodulatory and anti‐inflammatory properties.” Researchers determined a CBD regimen reduces joint damage from arthritis, mainly by strengthening cartilage. They also noted several different ways in which the body reacts favorably to the introduction of CBD, especially in mitigating the degradation and inflammation induced by cytokines.

Pain Relief - Control of pain initiation by endogenous cannabinoids

  • University of Naples Federico II
  • 1998

related conditions:

Pain Relief

Researchers concluded CBD significantly reduces discomfort and pain, in part, due to the interaction between two substances, PEA and anandamide. According to tests, they “act synergistically, reducing pain responses 100-fold more potently than each compound alone”.

Multiple Sclerosis - Evaluation of the Effects of Sativex (THC BDS: CBD BDS) on Inhibition of Spasticity in a Chronic Relapsing Experimental Allergic Autoimmune Encephalomyelitis: A Model of Multiple Sclerosis

  • The London School of Medicine and Dentistry
  • 2012

related conditions:

InflammationMultiple Sclerosis

A human study of Sativex showed significant benefits for patients dealing with Multiple Sclerosis. In fact, it was more effective than one of the most common treatments for MS-related spasticity, baclofen. So much so, they suggested CBD based drugs like Sativex become the primary tool for fighting stiffness related to MS.

Inflammation & CBD Research Overview

One of the best things about the explosion in popularity of CBD is all the peer-reviewed research now being conducted. CBD had long been seen as a less important chemical in cannabis, but all this new research is painting a very different picture.

Uncomfortable inflammation is something most people deal with from time to time, while others suffer daily, so understanding how CBD works has become valuable. The first thing that comes to mind when most people think about inflammation is swelling. As such, a lot of the research about CBD and inflammation highlights how much of a difference starting on a regimen can make.

Studies of lab mice have begun to uncover the specific chemicals involved in this process. One report found strong evidence that starting on CBD significantly decreases swelling-related chemicals in the system, while simultaneously improving the expression of the GPR55 receptor.

This growth in research has even begun to provide some interesting and important information. For instance, a report entitled Cannabinoids, endocannabinoids, and related analogs in inflammation was able to show that unlike many traditional anti-inflammatory medications, CBD doesn’t suppress eicosanoids production. The researchers found evidence that the introduction of CBD increases the production of eicosanoids, which decreases inflammation.

Other reports have also uncovered some of the key processes involved in controlling swelling with CBD. Other reports have also uncovered some of the critical processes involved in controlling swelling with CBD. One study suggests that CBD has “potent immunosuppressive and anti-inflammatory properties.” The team was able to determine this was most likely a result of an increase in extracellular adenosine, which helps send important signals around the body.

A different study called Diabetic retinopathy: Role of inflammation and potential therapies for anti-inflammation showed that CBD is an effective alternative treatment for vascular-neuroinflammation. They found that Synthetic forms of Cannabinoids decreased cartilage matrix degradation in animal models. They proposed that this is probably due to the cannabinoid receptor effects on prostaglandins and nitric oxide. Their data suggests CBD is particularly helpful at preventing unwanted swelling brought on by cytokines.

Another one of the most common symptoms of inflammation is uncomfortable stiffness in the muscles or joints. Luckily, much research has shown that CBD is also useful in treating this particular issue.

Cannabinoids also inhibit the rapid reproduction of B and T cells, which then stymies its proliferation. It is through this process that THC inhibited the spread of human T cells invigorated with antigen-primed dendritic cells. Cannabinoids proprieties like THC also inhibit the proliferation of mouse splenic T cells infused by concanavalin A, and B cells that are invigorated by LPS. This way, THC induces apoptosis of mouse T and B cells, and macrophages in primary splenic and thymic cultures. This is why researchers have proposed that cannabinoids elicit analgesic and immunomodulatory effects in inflammatory diseases such as arthritis.

One of the most debilitating symptoms of inflammation is the chronic pain that often accompanies it. Fortunately, one of the benefits of CBD we have a ton of evidence for is its ability to mitigate chronic pain.

Cannabidiol, as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress, concluded that CBD has a myriad of benefits for people dealing with autoimmune disorders, which quite often involve inflammation due to oxidative stress. This includes both types of diabetes (thanks to new research redefining type-two as an autoimmune disorder), Alzheimer’s disease, and notably for inflammation, rheumatoid arthritis, and neuropathic pain disorders.

In an animal study conducted by researchers entitled, Cannabinoids suppress inflammatory and neuropathic pain by targeting α3 glycine receptors focused on the connection between CBD and pain management, mainly via the glycine receptors. Their testing showed CBD significantly reduces inflammation and the associated pain. Perhaps more importantly, researchers also confirmed CBD provides this effect without the need for increasingly higher doses over time.

More research published by the National Institutes of Health suggests that CBD provides a distinct improvement of chronic pain and inflammation. Interestingly, the team also confirmed that CBD pretreatment boosts the benefits of some high-glucose-induced treatments.

Other teams have focused on specific treatments CBD dramatically alters. For instance, in an animal study looked into the impact of CBD pretreatment on cisplatin-induced nephrotoxicity, an unfortunate condition of the kidneys that’s sometimes a side-effect of chemotherapy. Their data suggests pretreatment with CBD dramatically reduces inflammation, oxidative stress, and, most importantly, cell death in the kidney.

Commentary by Ahmed Diab M.D.:

“There is a great deal of papers in the literature that explores the possible mechanisms and efficacy of cannabinoid derivatives on inflammation generally and in specific conditions. Most of them so far have been animal studies and are encouraging. Clinical randomized trials are warranted to assess the efficacy and safety of CBD on different inflammatory conditions.”

Best CBD for Inflammation

NoteCBD Capsules (10mg)

NoteCBD Capsules (10mg)

description

Enjoy the benefits of hemp extract with the convenience of a capsule. Each capsule contains a pre-portioned dose of full-spectrum hemp extract and MCT oil.

$45.00
  • CBD Per Serving: 10mg
  • Number Of Servings: 30
  • Cost Per Serving: $1.50
  • Cost Per/mg of CBD: $0.15
  • Shop now!

advantages

  • Full Spectrum
  • Lab Certified
  • Organic
  Servings per day Days supplied in one package Cost per week
Low Dosage (15 mg/day) 1.50 20.0 $15.75
Mid Dosage (30 mg/day) 3.00 10.0 $31.50
High Dosage (45 mg/day) 4.50 6.7 $47.25

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NoteCBD Capsules (25mg)

NoteCBD Capsules (25mg)

description

Enjoy the benefits of hemp extract with the convenience of a capsule. Each capsule contains a pre-portioned dose of full-spectrum hemp extract and MCT oil.

$95.00
  • CBD Per Serving: 25mg
  • Number Of Servings: 30
  • Cost Per Serving: $3.17
  • Cost Per/mg of CBD: $0.13
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advantages

  • Full Spectrum
  • Gluten Free
  • Lab Certified
  Servings per day Days supplied in one package Cost per week
Low Dosage (15 mg/day) 0.60 50.0 $13.30
Mid Dosage (30 mg/day) 1.20 25.0 $26.60
High Dosage (45 mg/day) 1.80 16.7 $39.90

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Pure CBD Oil Capsules (15mg)

Pure CBD Oil Capsules (15mg)

description

Every Day Optimal Soft Gel PCR Hemp Oil Capsule contains 15mg pure CBD from our proprietary high CBD strain of hemp.

$59.99
  • CBD Per Serving: 15mg
  • Number Of Servings: 30
  • Cost Per Serving: $2.00
  • Cost Per/mg of CBD: $0.13
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advantages

  • Easy Capsule Form
  • No GMO
  • All Natural
  Servings per day Days supplied in one package Cost per week
Low Dosage (15 mg/day) 1.00 30.0 $14.00
Mid Dosage (30 mg/day) 2.00 15.0 $28.00
High Dosage (45 mg/day) 3.00 10.0 $41.99

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Pure CBD Oil Capsules, (50mg)

Pure CBD Oil Capsules, (50mg)

description

Every Day Optimal Soft Gel PCR Hemp Oil Capsule contains 50mg of pure CBD.

$119.99
  • CBD Per Serving: 50mg
  • Number Of Servings: 30
  • Cost Per Serving: $4.00
  • Cost Per/mg of CBD: $0.08
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advantages

  • Easy Capsule Form
  • All Natural
  • GMP Compliant
  Servings per day Days supplied in one package Cost per week
Low Dosage (15 mg/day) 0.30 100.0 $8.40
Mid Dosage (30 mg/day) 0.60 50.0 $16.80
High Dosage (45 mg/day) 0.90 33.3 $25.20

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Suggested CBD Dosage for Inflammation

Dosage Per Day

Low

15 mg

Mid

30 mg

High

45 mg

Probably the question we get most often about all types of conditions is precisely how much CBD should someone be taking. As mentioned, everyone’s chemistry is different, and therefore, everyone’s reactions vary.

The only way to find the ideal dosage and routine for you is to try different things. Luckily, since CBD isn’t psychoactive, you can experiment away without having to worry about any changes in your sobriety.

All this is very important to consider, but that doesn’t mean we can’t provide a solid starting point to begin your journey. According to a research work titled, Cannabinoid Delivery Systems for Pain and Inflammation Treatment, conditions such as inflammation, the generally recognized safe dosage should not exceed 10mg per day of CBD- piperine per day.

After that, it’s up to you to discover your ideal situation. That said, it’s always advised to start with smaller dosages, as well as consult with your doctor.

Remember that CBD has become increasingly accepted around the country, but it’s still not legal everywhere. In fact, in some places having CBD is just as bad as having marijuana itself. So always be sure to stay on top of local laws, especially when you’re traveling.

Also, some CBD products still contain THC because of a noted benefit for specific conditions. So always be sure to double-check you’re only getting 100% CBD products if you’re not interested or able to get high. Regardless of how much you take, tracking your effectiveness will always be the most important thing you can do to improve your experience over time!

Tracking CBD Effectiveness For Inflammation

they should be tracking the effectiveness. For many, if CBD is doing its job, the effect is more about what you don’t feel than what you do. So staying aware of your body is the first key to understanding how CBD worked for you.

That said, taking CBD for inflammation tends to provide more easily noticed differences, especially in severe cases. Regardless, many people find keeping a journal of their doses, and daily impact offers a much clearer picture to the effect CBD is having for you.

However you choose to start taking CBD, finding the ideal routine is going to require some experimentation. While we aim to arm you with as much clear and relevant information as possible, at the end of the day, your personal experience is going to be different from everyone else.

That’s another critical reason keeping a journal can be such a valuable asset for anyone taking CBD for inflammation. You’d be surprised how much of a difference it makes when you can simply go back and check how your feelings today compare with the last few weeks.

Whatever method you choose for tracking the effectiveness of CBD, we hope you consider leaving your experiences here so others can learn from them. It only takes a moment to leave a short comment about how CBD did or didn’t help reduce your inflammation.

If you do decide to leave your experience, be sure to leave a score rating how CBD worked for pain reduction, stiffness reduction, as well as swelling reduction. If we work together, it’s only a matter of time until we uncover all the benefits and uses of CBD has to offer.

Written By
John Mace Alois is lead content creator at the Did CBD Work? project. He’s analyzed over 400 research papers related to Cannabidiol and helped publish over 55 works related to different conditions for the project. He majored in Cultural Anthropology, with a minor in English, from the University at Albany. He is an avid collector of art supplies and refurbishes old furniture in his spare time.
Reviewed By*
Ahmed Diab, M.D is a graduate of Ain Shams University in Cairo, Egypt. Senior He is currently Senior Medical Writer at NegidaClin. He has written dozens of manuscripts for pharmaceutical enterprises. He published works also included drug safety and efficacy for those with Parkinsons Disease and a historical analysis of the performance of prostheses in femoral neck fractures.

*The information contained here does not constitute medical recommendations. Ahmed Diab does not recommend a certain dosage or a certain indication for any of our products. Please consult your personal physician before using any product.

2 CBD Experiences From Inflammation Suffers

    Jack miller

    • May 20, 2020
    I had pain in my hip when running and couldn’t run more than a mile, I then took supremecbd and it reduce the pain and inflamation in joints I’m now running 6 miles most days with no pain at all

    effectiveness:

    Also effective for:

    • Arthritis
    • Joint Pain
    • Pain Relief

    dosage:

    40

    CBD Type:

    CBD Isolate

    How Did You Take It?:

    Oil

    Kris

    • May 23, 2020
    I started out using CBD isolate for endometriosis pain that continued after my hysterectomy 3 yrs ago. It helped a LOT. I also noticed that it’s had a mildly positive effect on my blood sugar numbers, but is most effective with my chronic insomnia. I’ve only ever taken CBD orally, either the flavored oil or in capsules, since I’ve multiple medical conditions & require higher doses.
    My advice, should you wish to follow it: check lab batch results for the company you’re thinking of buying CBD from. Reputable sellers will have them readily accessible. Also/Or, if your state has legalized marijuana, ask the dispensary employees what CBD they’d recommend. They’ll also be happy to discuss beginners dosage levels.

    effectiveness:

    Also effective for:

    • Arthritis
    • Joint Pain
    • Pain Relief

    dosage:

    150

    CBD Type:

    CBD Isolate

    How Did You Take It?:

    Oil

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