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Liver Disease overview

The liver is an essential organ in the digestion process, responsible for ridding your body of toxic substances. Liver disease is a condition that affects the organ’s ability to function. It can be caused by a wide range of reasons, but they can all eventually result in liver failure, which is life-threatening.

When the liver suffers damage, be it from excessive drinking or one of the other many causes, it works to repair itself, leaving behind scar tissue. As this scar tissue progresses, it develops into what is known as cirrhosis of the liver. The more scar tissue on your liver, the less functionality it retains.

Cirrhosis is not reversible, making early detection and mitigation paramount. If liver damage is diagnosed early on and the issue resolved, further damage can be significantly limited and even rarely reversed.

The signs of liver disease can be challenging to detect at first, as many people don’t experience symptoms until things progress to a severe place. When symptoms do occur, they often start with things such as fatigue, loss of appetite, nausea, weight loss, swelling in the lower half of the body, and bleeding easily.

Likely the most well-known causes of liver disease are chronic alcohol abuse and being obese, but there is a wide range of conditions that can eventually lead to cirrhosis. This includes infections such as Hepatitis A, B, and C, immune system problems such as primary biliary cirrhosis, genetic disorders such as Hemochromatosis, and even certain types of cancer or other growths like liver adenoma.

Other than alcohol abuse and obesity, several risk factors raise your chances of developing liver disease or cirrhosis. These factors include generally risky behaviors such as using shared needles, having unprotected sex, exposure to other’s bodily fluids, or exposure to chemicals. However, more innocuous-seeming things, like having tattoos or piercings or having received a blood transfusion before 1992, could also mean you have a higher chance of developing liver disease.

According to the CDC, around 4.5 million people in the US are living with liver disease, with global estimates suggesting more than 50 million people face this disease. Making things more dire, recent reports have shown the number of liver disease-related deaths have risen over the last ten years.

If you’re worried you or a loved one could be living with liver disease or cirrhosis, don’t wait to make a doctor’s appointment as soon as possible. Seeing a doctor is the only way to know for sure what you’re facing and get started on the right path forward.

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Table of Contents

CBD Research For Liver Disease

potencial impact research overview

Liver Disease - The endocannabinoid system and liver diseases

  • Alma Mater Studiorum University of Bologna
  • 2008

related conditions:

Liver Disease

This review goes over the role the endocannabinoid system might play in liver function and the pathophysiology of liver disease. Researchers note how the endocannabinoid system influences mechanisms responsible for inflammatory response and repairing cell damage. In conclusion, the authors state that molecules targeting CB1 and CB2 receptors may be a potential therapeutic agent in the treatment of liver diseases.

Liver Disease - Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death

  • National Institutes of Health
  • 2011

related conditions:

Liver Disease

The researchers investigated the effects of CBD on various hepatic complications using mouse models. Researchers found that CBD significantly attenuated liver inflammation, oxidative/nitrative stress, and even cell death. The team concluded that CBD holds promise as a novel protective strategy against hepatic complications caused by liver diseases.

Liver Disease - Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis

  • Mount Sinai School Of Medicine
  • 2011

related conditions:

Liver Disease

This report demonstrates that CBD induces apoptosis in hepatic cells, which may help resolve liver fibrosis. Researchers found that exogenous CBD treatment elicits a stress response, which causes a pro-apoptotic effect in hepatic cells, resulting in cell death. The authors propose that by selectively inducing the death of activated hepatic cells, CBD holds promise as a potential therapeutic agent for treating liver fibrosis.

Liver Disease - Therapeutic potential of cannabidiol against ischemia/reperfusion liver injury in rats

  • King Faisal University
  • 2011

related conditions:

Liver Disease

The team investigated the therapeutic potential of CBD in rat models exposed to liver injury. CBD was found to significantly attenuate the deterioration of liver injury and even improved overall liver damage. The author concludes that CBD represents a potential therapeutic option to protect the liver against injury and help repair any ensuing damage.

Liver Disease - Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol

  • University of South Carolina School of Medicine
  • 2011

related conditions:

Liver Disease

This study demonstrates how activation of TRPV1 receptors through administration of CBD can trigger myeloid-derived suppressor cells, which inhibit inflammation and hepatitis. Researchers found that this mechanism offered immunosuppressive benefits and suppressed hepatitis in rat models. The authors conclude that this CBD-induced interaction may constitute a novel therapeutic approach in treating inflammatory and hepatic diseases.

Liver Disease - Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice

  • Hadassah-Hebrew University Medical School
  • 2011

related conditions:

Liver Disease

Researchers wanted to investigate the effects of CBD on brain and liver functions using rat models induced with hepatic failure by thioacetamide. Researchers found that neurological and cognitive functions, as well as motor activity, were notably impaired in the thioacetamide-treated mice and that these functions were restored through exogenous CBD. The authors conclude that CBD restores liver function, normalizes 5-HT levels, and helps to improve brain pathology by normalizing brain function.

Liver Disease - Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation

  • Hadassah-Hebrew University Medical School
  • 2009

related conditions:

Liver Disease

The therapeutic effects of CBD on hepatic encephalopathy are caused by bile duct ligation, which is a model of chronic liver disease. Researchers found that cognitive and locomotor function was impaired by the ligation, but improved by CBD. The authors concluded that CBD reverses hepatic damage and compensates for the ligation effect in part from down-regulation of A(2)A adenosine receptor.

CBD Research That Might Be Useful for Symptoms of Liver Disease

potencial impact research overview

Inflammation - Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice

  • Tongji University School of Medicine
  • 2013

related conditions:

Inflammation

A study of mice concluded CBD has significant anti-inflammatory effects. The researchers also saw evidence that the expression of the GPR55 receptor was improved after starting on CBD. Treatment with CBD was shown to significantly decrease the levels of several inflammation-related chemicals in test subjects.

Nausea - Interaction between non-psychotropic cannabinoids in marijuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews

  • Palo Alto University, CA, USA
  • 2017

related conditions:

Nausea

CBD was shown to significantly suppress vomiting in lab rats and shrews. Researchers used another substance, known as cannabigerol (CBG) to reverse this suppression. Moderate doses of CBG and CBD are opposing each other at the 5-HT1A receptor, which is known to play an essential role in regulating nausea.

Pain Relief - Control of pain initiation by endogenous cannabinoids

  • University of Naples Federico II
  • 1998

related conditions:

Pain Relief

Researchers concluded CBD significantly reduces discomfort and pain, in part, due to the interaction between two substances, PEA and anandamide. According to tests, they “act synergistically, reducing pain responses 100-fold more potently than each compound alone”.

Liver Disease & CBD Research Overview

These days, CBD is well known for the many benefits it can provide to a wide variety of conditions. That said, it hasn’t always been the case. In fact, without the last 15 years of research, we would know very little about the power of CBD. However, thanks to the tireless research, we know many of the diseases CBD may be able to improve, including liver disease.

For example, a report called The endocannabinoid system and liver diseases looked into whether or not the endocannabinoid system could be a valuable tool in the fight against liver disease. The team concluded that CBD’s interaction with the endocannabinoid receptors could increase the effectiveness of mechanisms responsible for inflammatory control and cell repair.

Another report which reached a similar conclusion, Cannabidiol protects against hepatic ischemia/reperfusion injury by attenuating inflammatory signaling and response, oxidative/nitrative stress, and cell death, further investigated how CBD impacts hepatic complications. Their testing concluded CBD reduced oxidative stress, which reduced inflammation and controlled cell death. The team believes further research is needed, but their results provide a solid starting point.

A reduction in the severity of liver damage is something reported by several other studies, including Therapeutic potential of cannabidiol against ischemia/reperfusion liver injury in rats. Those researchers exposed rat models to CBD after suffering significant liver injury. The CBD was shown to improve the rate of deterioration caused by liver injury dramatically. They were so confident in their findings they suggested CBD is an invaluable tool in the repair and protection of the liver.

Another study which demonstrates how CBD reduces inflammatory damage to the liver is Role of myeloid-derived suppressor cells in amelioration of experimental autoimmune hepatitis following activation of TRPV1 receptors by cannabidiol. The team of researchers identified the mechanism which provided immunosuppressive benefits while simultaneously suppressing hepatitis. Analysis confirms CBD-induced interactions have a powerful role to play in the control of inflammation.

Aside from the ability of CBD to control liver damage and enhance repair, there are several ways in which cannabidiol could have a significant benefit to those living with liver disease. One study, entitled Cannabidiol causes activated hepatic stellate cell death through a mechanism of endoplasmic reticulum stress-induced apoptosis, found that CBD induces apoptosis in hepatic cells. Experts are optimistic about the potential of apoptosis to help regulate liver fibrosis. Treatment with CBD was shown to kill hepatic cells while leaving others alone selectively.

Further study into this effect on hepatic cells, such as Cannabidiol improves brain and liver function in a fulminant hepatic failure-induced model of hepatic encephalopathy in mice has offered interesting findings. The team observed that treatment with CBD was able to effectively remove any adverse effects brought on by thioacetamide. CBD appears to restore liver function, in part, by normalizing 5-HT levels.

Finally, a report called Cannabidiol ameliorates cognitive and motor impairments in mice with bile duct ligation highlighted the benefits provided by CBD on hepatic encephalopathy, common with liver disease. The impaired cognitive and locomotor function associated with ligation was dramatically improved by CBD.

Several other studies on CBD provide encouraging data about its value in treating symptoms of liver disease. While not explicitly about liver disease, many of these do provide encouraging data for its value. For instance, inflammation is a significant problem for many people living with liver disease. However, CBD is known to help reduce inflammation throughout the body thanks to reports like Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice. The researchers showed expression of the GPR55 receptor is central in CBD’s ability to control swelling.

Nausea is another common problem that many with liver disease tend to deal with. That said, CBD is known to be a powerful anti-nausea medication thanks to reports such as Interaction between non-psychotropic cannabinoids in marijuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews. The researchers showed that by interacting with the 5-HT1A receptors, CBD could dramatically reduce nausea.

However, for many living with liver disease, chronic pain is one of the most annoying symptoms they must learn to live with. That said, CBD does have some significant value to provide these people, as it’s a powerful plant-based pain reliever. A study called Control of pain initiation by endogenous cannabinoids indicated it’s the interaction between two distinct CBD related cannabinoids, PEA and anandamide, which increases their pain-reducing ability 100-fold.

Best CBD for Liver Disease

Diamond CBD Full Spectrum Honey Tincture (2500mg)

Diamond CBD Full Spectrum Honey Tincture (2500mg)

description

These tasty new honey tinctures are made of 100% all-natural honey, presenting a delicious addition to how to deliver you with the ideal amount of CBD. Available in strengths ranging from 25mg to 3500mg, add it to your morning coffee, tea, or just use it throughout the day to sweeten up every moment while enjoying all of the awesome benefits that CBD offers.

$128.00
  • CBD Per Serving: 83.33mg
  • Number Of Servings: 30
  • Cost Per Serving: $4.27
  • Cost Per/mg of CBD: $0.05
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advantages

  • Honey Flavor
  • Control Over Dosing
  • All Natural Ingredients
  Servings per day Days supplied in one package Cost per week
Low Dosage (300 mg/day) 3.60 8.3 $107.52
Mid Dosage (500 mg/day) 6.00 5.0 $179.21
High Dosage (700 mg/day) 8.40 3.6 $250.89

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Everyday Optimal CBD Oil Tincture (4000mg)

Everyday Optimal CBD Oil Tincture (4000mg)

description

CBD oil comes in many forms and potencies, but we haven’t seen any product sold by our competitors as powerful as our 4000mg cbd oil tincture. We make this powerful hemp oil product for people who demand fast, sure-fire relief from severe symptoms.

$289.99
  • CBD Per Serving: 133.33mg
  • Number Of Servings: 30
  • Cost Per Serving: $9.67
  • Cost Per/mg of CBD: $0.07
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advantages

  • Fast Effective Relief
  • Zero THC
  • Made In USA
  Servings per day Days supplied in one package Cost per week
Low Dosage (300 mg/day) 2.25 13.3 $152.25
Mid Dosage (500 mg/day) 3.75 8.0 $253.75
High Dosage (700 mg/day) 5.25 5.7 $355.25

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Relax Full Spectrum CBD Oil (3500mg)

Relax Full Spectrum CBD Oil (3500mg)

description

Relax Full Spectrum CBD Oil, available with an oil tincture dropper, delivers the ideal amount of CBD to meet all of your wellness needs. Made in the USA  from 100% high quality industrial hemp, this 3500 mg bottle of CBD is perfect for those wanting to combat stress, anxiety, and chronic pain.

$168.00
  • CBD Per Serving: 116.67mg
  • Number Of Servings: 30
  • Cost Per Serving: $5.60
  • Cost Per/mg of CBD: $0.05
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advantages

  • 100% Hemp Product
  • Made in USA
  • Full Spectrum
  Servings per day Days supplied in one package Cost per week
Low Dosage (300 mg/day) 2.57 11.7 $100.80
Mid Dosage (500 mg/day) 4.29 7.0 $168.00
High Dosage (700 mg/day) 6.00 5.0 $235.19

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Suggested CBD Dosage for Liver Disease

Dosage Per Day

Low

300 mg

Mid

500 mg

High

700 mg

The most frequently asked question here at DidCBDWork.com is easily how much CBD is the right amount to treat a given condition, such as liver disease. In a perfect world, we would have a simple answer that applies to everyone, but this isn’t a perfect world. Each person has a slightly different system and will have varying ideas of the ideal.

That said, we can still offer a solid starting point for you to begin your search. According to reports, larger doses of CBD, around 400-600mg, tend to be effective for conditions such as liver disease. However, research is still limited, and most experts suggest starting with low doses and working your way up over time. Remember, what takes a lot for one person, may take a lot less for you.

It’s also important to mention that CBD may be common these days, but it’s still treated as an illegal substance in many places. Certain laws even treat CBD and THC as virtually the same, meaning it can land you into some hot water. Just be sure to do a little research before taking any CBD with you on your travels.

Most CBD products will be THC-free, but this is not always the case. Some people find that CBD products that still contain a bit of THC are actually more effective at treating many conditions. However, if you’re not able to get high, you’ll need to ensure you only buy THC-free CBD products.

Any way you decide to move forward with CBD will still provide valuable information for those coming after you. As such, we ask everyone to leave their experience here, along with a score for how well CBD improved your pain, nausea, and inflammation. Together we can build a more well informed and well-equipped world.

Tracking CBD Effectiveness For Liver Disease

Something that many people seem to struggle with when first starting out on a regimen of CBD is understanding just how well things are going. It can be annoying to take CBD for a week and not feel any closer to knowing if it’s working at all. The truth is that even when working correctly, CBD tends to have a subtle impact, making paying attention to little changes in your body very important. Many experts agree this is particularly true for conditions such as liver disease, where you won’t notice an improvement in an obvious way.

What’s most important for people taking CBD to do is keep track of the gradual changes and symptoms. That’s why we always suggest keeping a simple journal of daily doses and the subsequent symptoms. Over the course of a few weeks, this sort of system can pay major dividends, especially when it comes to conditions such as liver disease.

Everyone has a different system and needs to remember to not rely too heavily on the experiences of others. While research is essential, at a certain point, you just have to get out there and try things for yourself. That’s why experimentation is still the best way to maximize the value of your CBD in the long-term.

While keeping a journal may not be for everyone, we do suggest at least giving it a try. Nothing we’ve ever found has come close to offering as many answers with as little effort. All it takes is some diligence and a desire to learn, and you will have the answer to if CBD works for you or not.

Anyone who does decide to track their progress taking CBD should think about leaving a brief overview of that progress here for others to learn from, along with a score for how well it improved any pain, nausea, inflammation. While this only takes a couple of minutes of your time, it could make a world of difference for people only getting started in the world of CBD.

Experiences Using CBD for Liver Disease

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