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Migraines overview

Migraine headaches are a fairly common but often debilitating condition that is estimated to affect millions of people worldwide. Migraines are most commonly described as extremely intense headaches that start as a dull ache that increases in intensity into a throbbing, pounding pain that is often accompanied by fatigue, dizziness, and nausea. However, according to most experts, these symptoms must occur at least five times before they can be considered a migraine.

The consensus breaks migraines into three broad categories, low-frequency episodic migraine, high-frequency episodic migraine, and chronic migraine. Low-frequency episodic migraines are usually considered anything lower than ten symptom days per month, while high-frequency episodic migraines are typically between 10 and 14 days a month. Those suffering from Chronic migraines must have had more days with a migraine in the last three months than without, meaning more than 15 symptom days per month. What’s worse is migraines are usually a progressive condition, with around 2.5% episodic migraine patients transitioning to a chronic case every year.

While it’s not entirely known what causes headaches and especially migraines, we do know several risk factors. Stress and anxiety are often factors in not only causing migraines but also making them much more severe.

However, that doesn’t mean migraines only happen when you’re stressed; in fact, it’s well documented for them to happen on the weekend or even on vacation. Doctors also think erratic eating and sleeping can contribute to your risk. They’re also much more common in women than men, but there is no significant difference among children along.

Ultimately while developing true chronic migraines is unlikely for the vast majority of people, even low-frequency episodic migraines can often drastically alter your quality of life. That’s why understanding and exploring all your treatment options is such an important step.

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Table of Contents

CBD Research For Migraines

potencial impact research overview

Migraines - Clinical endocannabinoid deficiency (CECD): can this concept explain therapeutic benefits of cannabis in migraine, fibromyalgia, irritable bowel syndrome and other treatment-resistant conditions?

  • 2018
  • GW Pharmaceuticals, USA

related conditions:

Migraines

Review of the available literature suggests the introduction of CBD has a positive biochemical and pathophysiological effect on several conditions related to a clinical endocannabinoid deficiency. CBD was shown to block spinal, peripheral, and gastrointestinal discomfort and pain, most likely through a combination of decreasing inflammation and controlling dopamine production.

Migraines - Effects of anandamide in migraine: data from an animal model

  • University of Pavia, Italy
  • 2011

related conditions:

Migraines

Research confirms that an issue with the endocannabinoid system may contribute to the development of several debilitating conditions. Systematic introduction of CBD can bind with these CB receptors and alleviate pain and discomfort. CBD significantly decreased the nociceptive behavior of the Sprague-Dawley rats during both phases of testing.

Migraines - Cannabinoids and hallucinogens for headache

  • Boston University School of Medicine, USA
  • 2013

related conditions:

Migraines

Cannabis, specifically the active ingredients CBD and THC, enjoyed a long history as a useful medical treatment before being classified a schedule 1 substance, barring it from prescription. However, as state marijuana laws have begun to loosen, more and more people are now turning to CBD for chronic pain relief.

Migraines - The endocannabinoid system and migraine

  • IRCCS Neurological Institute, Pavia, Italy.
  • 2010

related conditions:

Migraines

The review indicates that taking CBD positively impacts the endocannabinoid system, which is known to have a central and peripheral effect on processing pain. The experimental and clinical data strongly suggest CBD is an extremely promising tool for reducing and regulating physiological and inflammatory pain.

Migraines - Variations in the cannabinoid receptor 1 gene predispose to migraine

  • University of Manchester, UK
  • 2009

related conditions:

Migraines

Researchers tested the effectiveness of CBD for treating nausea, photophobia, and general pain-related disability. CBD was shown to provide massive and sustained improvement to all three symptoms. The team identified CNR1 as the primary receptor driving this effect, but said more research is necessary to fully understand the impact.

CBD Research That Might Be Useful for Symptoms of Migraines

potencial impact research overview

Pain Relief - Control of pain initiation by endogenous cannabinoids

  • University of Naples Federico II
  • 1998

related conditions:

Pain Relief

Researchers concluded CBD significantly reduces discomfort and pain, in part, due to the interaction between two substances, PEA and anandamide. According to tests, they “act synergistically, reducing pain responses 100-fold more potently than each compound alone”.

Glaucoma - Cannabinoid applications in glaucoma

  • The University of the Basque Country, Spain
  • 2011

related conditions:

Glaucoma

Cannabinoids have been shown to have a significant impact on the intraocular pressure usually associated with vision problems. According to testing, activation of CB1 not only reduces pressure, but it also has a neuroprotective effect on retinal cells.

Nausea - Interaction between non-psychotropic cannabinoids in marijuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews

  • Palo Alto University, CA, USA
  • 2017

related conditions:

Nausea

CBD was shown to significantly suppress vomiting in lab rats and shrews. Researchers used another substance, known as cannabigerol (CBG) to reverse this suppression. Moderate doses of CBG and CBD are opposing each other at the 5-HT1A receptor, which is known to play an essential role in regulating nausea.

Migraines & CBD Research Overview

As you have undoubtedly heard by now, CBD has been gaining major support over the last several years for its many incredible benefits, including migraine relief. As more people are seeking alternatives to prescription drugs, CBD has been a life-changer for many people suffering from chronic or episodic migraines. One of the primary ways researchers believe CBD accomplishes this is by significantly reducing discomfort and pain.

Interestingly, the team believes it’s a combination of anti-inflammatory and dopamine regulating effects that grant CBD such powerful pain relief. Other reviews, such as The endocannabinoid system and migraine, show both clinical and experimental research has been extremely encouraging for CBD’s value regulating physiological and inflammatory pain. Let’s take a quick look at all the other relevant research we have about CBD for migraine relief.

For most people who struggle with chronic or episodic migraines, high levels of pain and discomfort are the most glaring symptoms of any attack—as such, understanding how to lessen the sharp pain associated with migraines is likely the best way to improve the quality of life for these people. While we still don’t understand everything about why CBD has this effect, research is getting us closer.

Using rats for testing, a report called Effects of anandamide in migraine: data from an animal model, also suggests that CBD significantly reduces migraine pain, and states that in addition to this, researchers have also determined that problems with the endocannabinoid system are at the heart of many debilitating conditions. More importantly, they now believe by binding to the CB receptors, the systematic introduction of CBD is helping to correct these issues. 

Some researchers have proposed that cannabinoids, by their analgesic effects, are promising alternatives for the treatment of acute and prophylactic migraine pain. These classes of researchers posit that because of the significant presence of CB1 receptors in the brain, it makes it easy for these receptors to be targeted for the treatment of migraine.

While severe pain is one of the most common symptoms of migraines, it’s certainly not the only debilitating one. For example, Variations in the cannabinoid receptor 1 gene predispose to migraine showed strong evidence CBD is an effective treatment for two other primary symptoms of migraines. Severe nausea, which sometimes goes along with migraines, can be the hardest symptom to deal with, especially since it’s so difficult to hide.

In a study to test the efficacy and tolerability of dronabinol in chemotherapy-induced nausea and vomiting (CINV) in a 5-day trial, researchers discovered that nausea intensity and vomiting were lowest in patients treated with dronabinol as active treatments were well tolerated though the researchers suggested that further research needed to be carried out before conclusive interpretations could be made.

Commentary on Research by Ahmed Diab M.D.:

“Research on Migraine has yet to identify a single cause or a pathophysiological basis. A recent review (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5928495/) has compiled recent research that discusses the site of action and mechanisms of pain control in migraine. It is still early to confirm the efficacy and safety of CBD (or other cannabis derivatives) in the treatment of migraine. However, recent reports are encouraging.”

Best CBD for Migraines

Pure CBD Oil Capsules (15mg)

Pure CBD Oil Capsules (15mg)

description

Every Day Optimal Soft Gel PCR Hemp Oil Capsule contains 15mg pure CBD from our proprietary high CBD strain of hemp.

$59.99
  • CBD Per Serving: 15mg
  • Number Of Servings: 30
  • Cost Per Serving: $2.00
  • Cost Per/mg of CBD: $0.13
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advantages

  • Easy Capsule Form
  • No GMO
  • All Natural
  Servings per day Days supplied in one package Cost per week
Low Dosage (15 mg/day) 1.00 30.0 $14.00
Mid Dosage (50 mg/day) 3.33 9.0 $46.66
High Dosage (100 mg/day) 6.67 4.5 $93.32

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Pure CBD Oil Capsules, (50mg)

Pure CBD Oil Capsules, (50mg)

description

Every Day Optimal Soft Gel PCR Hemp Oil Capsule contains 50mg of pure CBD.

$119.99
  • CBD Per Serving: 50mg
  • Number Of Servings: 30
  • Cost Per Serving: $4.00
  • Cost Per/mg of CBD: $0.08
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advantages

  • Easy Capsule Form
  • All Natural
  • GMP Compliant
  Servings per day Days supplied in one package Cost per week
Low Dosage (15 mg/day) 0.30 100.0 $8.40
Mid Dosage (50 mg/day) 1.00 30.0 $28.00
High Dosage (100 mg/day) 2.00 15.0 $56.00

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NoteCBD Capsules (25mg)

NoteCBD Capsules (25mg)

description

Enjoy the benefits of hemp extract with the convenience of a capsule. Each capsule contains a pre-portioned dose of full-spectrum hemp extract and MCT oil.

$95.00
  • CBD Per Serving: 25mg
  • Number Of Servings: 30
  • Cost Per Serving: $3.17
  • Cost Per/mg of CBD: $0.13
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advantages

  • Full Spectrum
  • Gluten Free
  • Lab Certified
  Servings per day Days supplied in one package Cost per week
Low Dosage (15 mg/day) 0.60 50.0 $13.30
Mid Dosage (50 mg/day) 2.00 15.0 $44.33
High Dosage (100 mg/day) 4.00 7.5 $88.67

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Suggested CBD Dosage for Migraines

Dosage Per Day

Low

15 mg

Mid

50 mg

High

100 mg

A fairly common question we’re asked is precisely how much CBD someone should take for their condition. While it would be great if we could just provide everyone with the perfect answer, the fact of the matter is everyone is different, and your reaction may vary. What’s more than enough for one person may barely make any difference for another; Even if they’re similar in age, weight, and background.

The only way to get the perfect dosage for you is by experimenting until you find it. The good news is that there’s very little downside to taking too much CBD, except potentially being tired or having a dry mouth. So we suggest making a journal to track how much you’re taking and how it’s affecting your symptoms throughout the day.

Researchers have suggested that when it comes to the reaction of CBD on migraine, low doses tending to alleviate it while higher doses seem to trigger a headache in most cases. It is recommended that drugs should be taken under a doctor’s supervision.

Tracking CBD Effectiveness For Migraines

Tracking your progress with anything is a distinct challenge if you don’t fully understand what you should be looking out for. Taking CBD for migraine relief is no different, and will likely require some experimentation. That said, it may be slightly easier to track than other conditions since most migraine sufferers already keep fairly detailed reports of the frequency and severity of their symptoms.

Obviously, a fewer number of migraine days per month is a clear win, but it’s also important to note if the severity of your symptoms is reduced when you do have a flare-up. Since severe pain and discomfort are the most common symptoms of migraines, it only makes sense to start there when tracking your success.

It can be hard to notice at first, but after a few weeks, most people note a distinct decrease in pain. The truth is that everyone is different, and the only way to truly understand what CBD will do to your body is by paying attention to it. However, that doesn’t mean we can help others.

By leaving a comment about your experience using CBD for migraine relief, you’ll be helping someone else on their own journey. If you do leave a comment, be sure to include a score for the general pain relief, nausea relief, and reduction in migraine days. By working together, we can help the most people as possible improve their quality of life once and for all.

3 CBD Experiences From Migraines Suffers

    A.Angel

    • August 1, 2019
    I have suffered with migraines and daily tension headaches for 40 yrs. For approximately 20 of those yrs I seeked out traditional treatments with Doctors and specialist. I have tried most everything that has been suggested at no prevail. Some of the medications were so harsh i couldn’t tolerate them, and for the most part i did not see acceptable results. Some treatments even made it worse. I had heard of CBD oil for many different issues but because of the stigma that surrounds it’s relation with the marijuana plant I ignored it for yrs. Until one day a close friend I had known for yrs, who also suffered as I did, told me she had tried it and her headaches we gone. I decided to research it, after doing so I thought it would be worth a try. I started taking it right away I noticed reduction in anxiety and SLEEP! For the first time in yrs i was sleeping. After approximately 2 weeks my daily headaches and migraines were GONE! I have been taking it approx 6 months and have had 3 minor migraines. I also helps me a great deal with Fibromyalgia. I was taking 6-8 ibuprofen daily for many yrs. Now i may take 2-4 a month! CBD oil has changed my life in many ways. Living as i have lived for so long I’m still somewhat in shock at how well this all natural product has worked for me. I do not have any ill side effects. The only immediate side effects is, i feel more relaxed and when i do fall asleep I sleep much better and longer.

    effectiveness:

    Also effective for:

    • Headaches
    • Nausea
    • Pain Relief
    • Sleep

    dosage:

    150mg capsules once a day

    CBD Type:

    N/A

    How Did You Take It?:

    N/A

    Janessa Hershman

    • February 7, 2020
    I used to suffer from headaches/migraines 15+ days out of the month. When I finally started taking a 10:1 CBD/THC capsule, my headaches/migraines quickly became a thing of the past. I rarely suffer from headaches/migraines now but before I started taking these capsules, I was a regular in our local emergency room.

    effectiveness:

    Also effective for:

    • Headaches
    • Nausea
    • Pain Relief
    • Sleep

    dosage:

    10

    CBD Type:

    CBD & THC

    How Did You Take It?:

    Pill

    Tommy Toker

    • May 27, 2020
    I get migraine headaches that seem to coincide with barometric pressure. I use tinctures to medicate for pain relief. My current mix is a Cannabis flower that has a 10/10 THC/CBD mix. Smoking is ineffective. However, consuming it and digestion usually leads to an overall body buzz that combined with a short nap, ( time for it to kick in) usually leads to relief.

    effectiveness:

    Also effective for:

    • Headaches
    • Nausea
    • Pain Relief
    • Sleep

    dosage:

    3

    CBD Type:

    CBD & THC

    How Did You Take It?:

    Edible

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