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Mood Disorders overview

The term mood disorders cover a wide range of conditions that impact your general emotional state. This typically results in unstable or variable mood and behavior, often bad enough to affect the ability to function in the world.

This means mood disorders usually have symptoms related to either anxiety, depression, mania, or some combination. One of the most significant concerns when it comes to mood disorders is the possibility that they could raise someone’s risk of suicide.

There is a wide range of specific disorders that fall under the umbrella of mood disorder. Two of the most common are major depressive disorder, which is characterized by prolonged and persistent periods of sadness and bipolar disorder, which includes alternating periods of depression and mania.

Other mood disorders include seasonal affective disorder, premenstrual dysphoric disorder, disruptive mood dysregulation disorder, cyclothymic disorder, along with many others. Another common form of mood disorders are those related to depression brought on by illness, medication, or substance use.

While the symptoms of each mood disorder will vary, the most common among them tend to be things such as ongoing depression and anxiety, feelings of helplessness, low self-esteem, and excessive guilt. Other common issues tend to go hand-in-hand with mood disorders, such as relationship problems, trouble sleeping, and leaving home.

Unfortunately, mood disorders are unlikely to resolve themselves without some form of intervention. This makes having healthcare professionals you feel comfortable being honest with very important for anyone dealing with a mood disorder.

The precise cause of mood disorders depends on the given condition, but most are relatively mysterious in nature. One thing researchers do know is that mood disorders are likely caused, in part, by an imbalance of various brain chemicals. These abnormalities may be inherited, as mood disorders are known to run in families. Traumatic life events are also known to be a cause of depression and anxiety.

As mentioned, the most common risk factors for mood disorders are either having a family history or facing a traumatic life event. While many other things can raise your risk, these are the most prevalent. Ongoing stress can also be a contributor to developing mood disorders.

According to reports, around 21 million Americans 18 and older are living with some type of mood disorder. Researchers indicate nearly 9.7% of adults faced one in the last year. Reports also indicate the risk of depression in women is almost twice as high as it is for men.

If you’re concerned that you or a loved one could be dealing with a mood disorder, you need to talk to a doctor as soon as possible. Only a trained professional can accurately diagnose any psychological disorder and provide the right path forward.

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Table of Contents

CBD Research For Mood Disorders

potencial impact research overview

Mood Disorders - Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders

  • Federal University of Minas Gerais
  • 2012

related conditions:

Mood Disorders

This review looks at recent in vivo studies to understand the underlying mechanisms behind CBD’s pharmacological properties. The authors suggest that these mechanisms are not unitary, but rather are based on the behavioral response being measured. They conclude that additional research is needed to investigate the involvement of other possible mechanisms, although it highlights CBD’s safety profile and range of therapeutic potential.

Mood Disorders - The endocannabinoid system and the treatment of mood and anxiety disorders

  • The Rockefeller University
  • 2009

related conditions:

Mood Disorders

The authors highlighted a growing body of evidence demonstrating the role endocannabinoid deficiency may play in depressive responses, as well as the antidepressant effect of exogenous endocannabinoid supplementation. In their conclusion, the authors argue that both clinical and preclinical data suggest cannabinoid receptor signaling may be a useful target in the development of novel therapies for mood and anxiety disorders.

Mood Disorders - The endocannabinoid system and psychiatric disorders

  • University of Insubria
  • 2010

related conditions:

Mood Disorders

This report summarizes the latest data on the role of the endocannabinoid system in controlling mood disorders. The authors state that current research indicates exogenous cannabinoid therapy may be a useful therapeutic alternative for the treatment of depressive disorders. The review concludes that there is therapeutic potential in the pharmacological manipulation of the endocannabinoid system for treating a variety of mood disorders.

Mood Disorders - The endocannabinoid system in the regulation of emotions throughout lifespan: a discussion on therapeutic perspectives

  • Complutense University
  • 2012

related conditions:

Mood Disorders

The authors summarize the latest information on the role of the endocannabinoid system in controlling emotional and anxiety-related disorders. They discuss data from animal models indicating the endocannabinoid system plays a crucial role in brain development and is most likely involved in the control of emotional states during early developmental stages. They conclude the endocannabinoid system is a promising strategy in the management of several anxiety and mood disorders.

Mood Disorders - Endocannabinoid system dysfunction in mood and related disorders

  • University of Newcastle upon Tyne
  • 2011

related conditions:

Mood Disorders

The team examined the therapeutic potential of exogenous cannabinoids in various psychiatric disorders. Their review of the available literature indicates endocannabinoids may hold antidepressant and antipsychotic properties. They believe CBD could offer therapeutic potential in the treatment of mood disorders. In their conclusion, the authors note that additional research is needed to understand the full role of the endocannabinoid system in psychiatric disorders to help assess their therapeutic potential.

Mood Disorders - Effects of cannabidiol (CBD) on regional cerebral blood flow

  • University of São Paulo
  • 2004

related conditions:

Mood Disorders

This report seeks to investigate how the potential anxiolytic effects of CBD are mediated using functional neuroimaging. In a double-blind procedure featuring human volunteers, researchers found that CBD significantly decreased subjective anxiety and increased mental sedation, whereas no change was observed in the control group. They conclude this data suggests CBD has anxiolytic properties, which are mediated by an action on limbic and paralimbic areas of the brain.

Mood - Sub-chronic impact of cannabinoids in street cannabis on cognition, psychotic-like symptoms and psychological well-being

  • University College London, UK
  • 2012

related conditions:

Mood Disorders

A much lower rate of psychosis-like symptoms were found in those who used marijuana with contained both THC and CBD, compared with types high only in THC. Researchers conclude the CBD attenuates the psychotic-like effects, leading to a greater sense of well-being and an overall improved mood.

CBD Research That Might Be Useful for Symptoms of Mood Disorders

potencial impact research overview

Anxiety - Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence

  • University of Melbourne, Australia
  • 2013

related conditions:

Anxiety

A comprehensive review of all the plant-based medicine which has had both preclinical and human clinical trials conducted about their anxiolytic-like effect. An analysis of over 1500 papers identified 21 plants which had been adequately tested, with one of the most successful of these plants found to be CBD enriched Cannabis species.

Mood Disorders- Acute Effects of a Single, Oral dose of d9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) Administration in Healthy Volunteers

  • University of Barcelona
  • 2012

related conditions:

Mood Disorders

Unlike THC, which was shown to have acute behavioural and physiological effects, CBD was proven safe and well tolerated by healthy patients. In fact, while THC was associated with higher risks of anxiety and dysphoria, there were no differences between the CBD and placebo on any negative symptomatic variable.

Sleep - Cannabis, Cannabinoids, and Sleep: a Review of the Literature

  • Palo Alto University, CA, USA
  • 2017

related conditions:

Sleep

This report concludes CBD holds promise for significantly increasing the quality of REM sleep. Researchers believe it could one day be a primary force behind improved overall sleep quality. CBD was even shown to reduce daytime sleepiness in many patients.

Mood Disorders & CBD Research Overview

Many people are learning every day about the wonderful world of CBD. Thanks to a growing pile of peer-reviewed evidence, we now know many more of the benefits of taking CBD. One condition which has also been shown to be somewhat mitigated by taking a regimen of CBD is mood disorders.

One reason so many experts are looking to CBD in the fight against mood disorders is the adaptive effect it seems to provide. Instead of having the same impact on each person, CBD has instead been observed to target more dysfunctional systems depending on the subject. This has been noted in reports such as Multiple mechanisms involved in the large-spectrum therapeutic potential of cannabidiol in psychiatric disorders.

The team of researchers found that the mechanisms behind CBD’s pharmacological properties are heavily influenced by the behavioral response being observed. While they believe more research is ultimately needed, these early results have been quite fascinating.

Another report entitled The endocannabinoid system in the regulation of emotions throughout lifespan: a discussion on therapeutic perspectives summarized all the available information on the role of the endocannabinoid system to benefit emotional disorders. The researchers highlighted evidence that suggests the endocannabinoid system plays a critical role in brain development. They ultimately concluded cannabinoids, such as CBD, hold a lot of promise as a supplement to therapies for anxiety and mood disorders.

The team behind, Effects of cannabidiol (CBD) on regional cerebral blood flow, wanted to determine any potential anti-anxiety impact of CBD. Their neuroimaging showed cannabidiol dramatically reduced anxiety in subjects while increasing mental sedation.

Additionally, reports such as Sub-chronic impact of cannabinoids in street cannabis on cognition, psychotic-like symptoms and psychological well-being have provided ample evidence that CBD doesn’t increase the chances of psychotic-like effects observed with THC treatment. The team concluded that CBD should be held as a valuable tool for being able to help control mood without any notable side-effects.

This same phenomenon was noted by the researchers behind Acute Effects of a Single, Oral dose of d9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) Administration in Healthy Volunteers. They also showed that while THC provides some relief from anxiety, it could also trigger worse symptoms in particular cases. CBD, on the other hand, wasn’t shown to have any of the negative side-effects, while retaining the positives.

Research has also shown that CBD may be able to mitigate some symptoms of various mood disorders, including anxiety and depression. For example, The endocannabinoid system and the treatment of mood and anxiety disorders showed clinical and preclinical evidence that suggests CBD should be seen as a potential addition to existing treatments for anxiety and mood disorders.

Summaries of all the latest evidence on CBD and mood disorders have offered interesting insight. The endocannabinoid system and psychiatric disorders showed the endocannabinoid system, and CBD may be a viable alternative treatment for depressive disorders. Not only did their analysis prove the value of CBD to treat depression, but also various other mood disorders as well.

Other reports into the impact of CBD on mood disorders have yielded similar results. One such study is Endocannabinoid system dysfunction in mood and related disorders which examined the therapeutic potential of cannabinoids, such as CBD, to reduce symptoms of psychiatric disorders. They concluded that while more research is needed, their findings should provide a solid starting point for further inquiry.

CBD may also hold particular value for those who are looking to reduce their anxiety without taking heavy lab-made medications. Reports such as Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence, show that CBD is a powerful all-natural solution. Their analysis of over 1500 papers identified 21 plant-based medicines for anxiety, with CBD ranking supreme.

Finally, many people who live with mood disorders can suffer from difficulty falling and staying asleep. Luckily, CBD has been shown to provide a powerful benefit to our REM sleep. Cannabis, Cannabinoids, and Sleep: a Review of the Literature, showed treatment with CBD could dramatically improve the quality of REM sleep while also reducing daytime sleepiness.

Best CBD for Mood Disorders

Everyday Optimal CBD Capsules (200mg)

Everyday Optimal CBD Capsules (200mg)

description

Are you looking for something stronger than almost any CBD oil product on the market? Then you’ll love the newest addition to our high potency CBD line. With each capsule containing 200mg of pure CBD, you’ll experience all-natural, long-lasting relief for tough pain, sleep problems, anxiety, and more.

$299.99
  • CBD Per Serving: 200mg
  • Number Of Servings: 30
  • Cost Per Serving: $10.00
  • Cost Per/mg of CBD: $0.05
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advantages

  • Highest Capsule In USA
  • 100% USA Made
  • THC Free
  Servings per day Days supplied in one package Cost per week
Low Dosage (10 mg/day) 0.05 600.0 $3.50
Mid Dosage (30 mg/day) 0.15 200.0 $10.50
High Dosage (60 mg/day) 0.30 100.0 $21.00

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NoteCBD Capsules (25mg)

NoteCBD Capsules (25mg)

description

Enjoy the benefits of hemp extract with the convenience of a capsule. Each capsule contains a pre-portioned dose of full-spectrum hemp extract and MCT oil.

$95.00
  • CBD Per Serving: 25mg
  • Number Of Servings: 30
  • Cost Per Serving: $3.17
  • Cost Per/mg of CBD: $0.13
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advantages

  • Full Spectrum
  • Gluten Free
  • Lab Certified
  Servings per day Days supplied in one package Cost per week
Low Dosage (10 mg/day) 0.40 75.0 $8.87
Mid Dosage (30 mg/day) 1.20 25.0 $26.60
High Dosage (60 mg/day) 2.40 12.5 $53.20

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Relax Full Spectrum CBD Oil (3500mg)

Relax Full Spectrum CBD Oil (3500mg)

description

Relax Full Spectrum CBD Oil, available with an oil tincture dropper, delivers the ideal amount of CBD to meet all of your wellness needs. Made in the USA  from 100% high quality industrial hemp, this 3500 mg bottle of CBD is perfect for those wanting to combat stress, anxiety, and chronic pain.

$168.00
  • CBD Per Serving: 116.67mg
  • Number Of Servings: 30
  • Cost Per Serving: $5.60
  • Cost Per/mg of CBD: $0.05
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advantages

  • 100% Hemp Product
  • Made in USA
  • Full Spectrum
  Servings per day Days supplied in one package Cost per week
Low Dosage (10 mg/day) 0.09 350.0 $3.36
Mid Dosage (30 mg/day) 0.26 116.7 $10.08
High Dosage (60 mg/day) 0.51 58.3 $20.16

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Suggested CBD Dosage for Mood Disorders

Dosage Per Day

Low

10 mg

Mid

30 mg

High

60 mg

We’re always asked what the specific amount of CBD is needed to treat a given problem, such as mood disorders. While it would be great if we had the simple answer ready to go for each problem, the truth is it’s not that simple. The only way to identify your ideal routine is to try different things and pay attention to how your body reacts.

That said, we can offer a jumping-off point for you to begin your search for the ideal routine. According to experts, starting between 20-40mg of CBD daily is a solid starting point for depressive disorders, while other reports have shown larger doses, as high as 400mg+ are ideal for treating severe anxiety. This wide range means you’ll have extra work to do to determine what the right amount needed to manage your most prominent issues.

It’s also worth mentioning that while CBD has become an everyday thing in many parts of the country, this isn’t the case everywhere. In fact, lots of places still consider THC and CBD to be essentially the same, meaning you must take care when traveling. If you do your due diligence, you’ll avoid any potentially embarrassing situations.

We should also mention that while many CBD products will be THC-free, this isn’t always the case. Some people find that with a bit of THC still present, CBD is more able to provide many of its benefits. That said, if you don’t want to risk getting high, you have to ensure you only by THC-free products.

Whichever way you end up taking and tracking your CBD usage, we sincerely hope you choose to leave your experiences here for others to learn from. We all have some knowledge to share, and by working together we can make the task easier for the next person to come along. Information is power, and what better information than experience from real users?

Tracking CBD Effectiveness For Mood Disorders

Something that tends to be difficult for many people beginning CBD treatment is identifying precisely how well things are going. It’s very understandable, given the relatively subtle impact CBD is known for. That doesn’t make things less frustrating for newcomers, but we suggest sticking with it and paying attention to what your body is telling you.

One thing we can suggest to improve your chances of finding success with CBD is keeping a simple journal of your dosages and daily experience. For many people, all it takes is some commitment to tracking their progress before they begin to understand whether or not CBD is working for them.

Everyone is different, and each person’s ideal regimen reflects that. What’s most effective for one person may have little to no impact on another. The only way to find what works best for you is by trying lots of different things and keeping a keen eye on the results.

We’re often asked if keeping this hypothetical journal is totally necessary for success. While it’s true you could get everything you want out of CBD right away; it’s much more likely that you will have to try some different things before feeling it’s right. That’s where tracking your daily experience becomes a significant benefit.

If you do choose to track your first attempts at taking CBD, we ask that you consider leaving those experiences here for others to build from. We all needed a bit of help when we were starting out, so why not make things that much easier for the next person. All we want is a brief description of your experience, along with scores for how well you feel CBD improved your anxiety, mood swings, and trouble sleeping.

Written By
John Mace Alois is lead content creator at the Did CBD Work? project. He’s analyzed over 400 research papers related to Cannabidiol and helped publish over 55 works related to different conditions for the project. He majored in Cultural Anthropology, with a minor in English, from the University at Albany. He is an avid collector of art supplies and refurbishes old furniture in his spare time.

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