MS & CBD Research Overview
CBD has grown from a niche medicine only known by a few, to a massive industry of its own in just a short period. This is because millions of people are now aware of how CBD can improve a wide range of conditions. One benefit with a massive amount of evidence behind it relates to multiple sclerosis. In fact, one of the only CBD-based prescriptions in America is called Sativex and been proven to improve symptoms for those living with MS significantly.
An overview of Sativex called Sativex: clinical efficacy and tolerability in the treatment of symptoms of multiple sclerosis and neuropathic pain, explained how most people use the medication, as well as how much is generally taken per week. They concluded Sativex spray provides 20-30mg of CBD per day while providing a benefit for neuropathic pain.
As a painful condition, anything which can regulate the pain associated with multiple sclerosis is much needed. A report called Sativex for the management of multiple sclerosis symptoms discusses how CBD based medicines, such as Sativex, are able to reduce pain in patients with MS. They tested over 400 people and found CBD and THC mixtures actually provide a wide range of benefits for those living with central nervous system dysfunction.
A different report, called Meta-analysis of cannabis based treatments for neuropathic and multiple sclerosis-related pain, reviewed all of the available evidence on Sativex. The team concluded CBD-based Sativex is both safe and effective in the treatment of chronic and debilitating pain associated with MS.
Other researchers have looked into other ways in which CBD is able to reduce neuropathic pain. A study called Oromucosal delta9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, open-label, 2-year extension trial, found CBD can reduce pain without any significant adverse side effects. Interestingly, the team noted no reduction in effectiveness, even after over two years of use.
Other CBD-based medications are also looking to secure approval as a treatment for MS-related pain and discomfort. For example, Nabiximols in the treatment of spasticity, pain and urinary symptoms due to multiple sclerosis, highlights a new medication which promises to improve pain for those living with MS. Their clinical trials suggest the drug can not only improve pain, but spasticity, and even bladder dysfunction related to MS.
Even outside of specifically MS-related medications, CBD has been shown time and time again to be a significant source of pain relief for a wide range of reasons. A report called, Control of pain initiation by endogenous cannabinoids, showed CBD is able to reduce discomfort thanks to the interaction of PEA and anandamide, which provide powerful pain relief.
Outside of general pain and discomfort, one of the most common symptoms of MS is spasticity or tightness in the muscles and joints, making it harder to move effectively. Luckily, Sativex, and other CBD-based medications have been shown to reduce the severity of spasticity in MS patients significantly.
One such report is called THC and CBD oromucosal spray (Sativex®) in the management of spasticity associated with multiple sclerosis, and it shows just how well Sativex can control spasticity. The randomized, clinical evidence indicates Sativex significantly reduced spasticity, increasing overall well-being in patients. Perhaps more importantly, the team found evidence which suggests the adverse effects of CBD can be mitigated via uptitration.
Another report on Sativex, called Clinical efficacy and effectiveness of Sativex, a combined cannabinoid medicine, in multiple sclerosis-related spasticity, showed that CBD is one of the most reliable and effective treatments for spasticity currently available. Pain was reduced, while functional status was greatly increased.
Randomized trials of Sativex, such as Sativex long-term use: an open-label trial in patients with spasticity due to multiple sclerosis, have shown similar results. Researchers highlighted the significant pain-relieving effects of CBD, especially to control central nervous system pain and discomfort. Their data also showed a statistically relevant connection between Sativex and reduced spasticity.
As such a common symptom of MS, any reports showing the benefits of CBD-based Sativex to reduce spasticity, is a welcome sight. Another report which does just this is A double-blind, randomized, placebo-controlled, parallel-group study of Sativex, in subjects with symptoms of spasticity due to multiple sclerosis, Over the course of a 15-week, double blind trial, the team concluded CBD could reduce spasticity quite a bit. Impressively, this effect was shown even in advanced cases of MS.
Outside of the pain relief, and spasticity reducing power of CBD, there are still several ways in which medications such as Sativex are improving the lives of those suffering. A study called, Cannabidiol provides long-lasting protection against the deleterious effects of inflammation in a viral model of multiple sclerosis: a role for A2A receptors, showed that CBD activates the Adenosine A2A receptors, which provides a ton of anti-inflammatory power. This effect was so powerful, the researchers even believe CBD could be effective at helping any conditions, which involves inflammation.
Another report has noted just how well CBD can improve inflammation symptoms. The researchers behind, Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice, showed CBD is able to provide such a potent anti-inflammatory effect thanks to the expression of the GPR55 receptor, while also reducing levels of inflammation-causing chemicals.
Finally, there has been plenty of evidence which suggests CBD is a powerful anti-anxiety medication. Since anxiety is a symptom that sometimes goes along with MS, it’s nice to know that CBD is helping cover you there too. A report called, Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence, studied over 1500 papers on the best all-natural anxiety medications. The team found 21 different substances that have been shown to provide some positive effects, with none coming close to the anti-anxiety effect offered by CBD.