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Neurodegeneration overview

Neurodegenerative diseases are a broad range of conditions that are characterized by a reduction in the ability to control your body’s activity. This can include your balance, locomotion, and ability to speak. However, it can also affect your ability to breathe or even your heart’s ability to pump blood.

The vast majority of these conditions are genetic, while others can be triggered by substance abuse or as a complication of another diagnosis. Other common causes of neurodegenerative disorders include exposure to toxins and chemicals, or even contracting certain viruses.

In the case of some neurodegenerative conditions, researchers still haven’t been able to determine a specific cause. These conditions are some of the most mysterious, and therefore hard to treat out there. One thing all neurodegenerative disorders have in common is that they can significantly impact your quality of life.

The primary symptom in most neurodegenerative disorders is an abnormality in the function of nerves or muscle systems around the body. Where this occurs, how severe it is, and how rapidly it progresses can all vary significantly depending on which condition you’re dealing with.

Many of these degenerative nerve disorders are life-threatening, or at the very least, quite severe. While the course of action and outlook will depend on your diagnosis, the vast majority of these disorders have no known cure. However, we’ve developed many treatments that promise to reduce pain and increase overall mobility.

Some of the most common neurodegenerative disorders include things such as Alzheimer’s, Parkinson’s, and Multiple Sclerosis. One thing that is significantly impeding the progress of neurodegeneration treatments is the broad range of specific disorders that each have their own set of challenges and symptoms.

While genetics likely has the most significant role to play on our risk of developing various neurodegenerative disorders, the actual connection for most of these conditions is mostly conjecture at this point. That said, one thing we know that increases your chances of developing a neurodegenerative disorder is increasing age.

According to rough estimates, around 6.5 million people in the US are living with some type of common neurodegenerative disorder. The most common by far is Alzheimer’s at nearly five million people, followed by Parkinson’s at one million, and MS at 400,000. These conditions have been on the rise, with reports suggesting as many as one in five Americans over the age of 65 will have a neurodegenerative disorder by the year 2030.

Neurodegenerative disorders are extremely serious and require intervention as soon as possible. If you’re worried that you or a loved one could be living with one of these debilitating conditions, please don’t hesitate to get in contact with a medical professional. While many of these disorders can be terminal, early detection and treatment are the biggest factors in extending life and increasing the quality of lived years.

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Table of Contents

CBD Research For Neurodegeneration

potencial impact research overview

Neurodegenerative Disorders - Cannabidiol: a promising drug for neurodegenerative disorders?

  • University of Naples Federico II
  • 2009

related conditions:

Neurodegeneration

For this review, the authors note the detriment neurodegenerative diseases pose in industrialized countries, while highlighting the promise cannabis-based compounds such as CBD offer in helping manage them. Specifically, they highlight research reviewing the neuroprotective and antiinflammatory properties of cannabinoids and how they impact neurodegenerative diseases. They conclude that CBD, lacking any psychotropic effect, could be a promising therapeutic agent in the treatment of neurodegeneration.

Neurodegenerative Disorders - Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid?

  • University of Madrid
  • 2013

related conditions:

Neurodegeneration

The research team behind this study sought to explore the neuroprotective potential of CBD and how its anti-inflammatory and antioxidant properties may provide benefits to those living with neurodegenerative disorders. They found that CBD not only acts on the endocannabinoid system but also causes direct or indirect activation of additional metabotropic receptors. The authors conclude that CBD therapy holds great promise for the treatment of neurodegenerative disorders.

Neurodegenerative Disorders - Transdermal delivery of cannabidiol attenuates binge alcohol-induced neurodegeneration in a rodent model of an alcohol use disorder

  • University of Kentucky
  • 2013

related conditions:

Neurodegeneration

This study aimed to advance the preclinical development of transdermal delivery of CBD for the treatment of alcohol-induced neurodegeneration. Using a 5.0% CBD gel on rat models, researchers observed a 48% reduction in neurodegeneration, as well as notable gains in neuroprotection. Their results demonstrate the potential of using transdermal CBD treatment in alcohol-induced neurodegeneration.

Neurodegenerative Disorders - Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders

  • Pontifical Catholic University
  • 2012

related conditions:

Neurodegeneration

Researchers sought to understand the usefulness of CBD in the treatment of memory impairment caused by neurodegenerative disorders. Their findings indicated that chronic CBD treatment improved recognition memory in rat models. They also found that CBD may hold potential in the treatment of the cognitive decline associated with neurodegenerative disorders.

Neurodegenerative Disorders - Cannabidiol normalizes caspase 3, synaptophysin, and mitochondrial fission protein DNM1L expression levels in rats with brain iron overload: implications for neuroprotection

  • Pontifical Catholic University
  • 2014

related conditions:

Neurodegeneration

In this study, researchers analyze the expression level of brain proteins involved in mitochondrial fusion and fission mechanisms. They found that CBD rescued iron-induced neurodegenerative effects, bringing levels in line with the control group. These results suggest that iron may affect mitochondrial dynamics, and CBDs neuroprotective and memory-rescuing properties may offer promise in the treatment of neurodegenerative disorders.

CBD Research That Might Be Useful for Symptoms of Neurodegeneration

potencial impact research overview

Anxiety - Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence

  • University of Melbourne, Australia
  • 2013

related conditions:

Anxiety

A comprehensive review of all the plant-based medicine which has had both preclinical and human clinical trials conducted about their anxiolytic-like effect. An analysis of over 1500 papers identified 21 plants which had been adequately tested, with one of the most successful of these plants found to be CBD enriched Cannabis species.

Nausea - Interaction between non-psychotropic cannabinoids in marijuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews

  • Palo Alto University, CA, USA
  • 2017

related conditions:

Nausea

CBD was shown to significantly suppress vomiting in lab rats and shrews. Researchers used another substance, known as cannabigerol (CBG) to reverse this suppression. Moderate doses of CBG and CBD are opposing each other at the 5-HT1A receptor, which is known to play an essential role in regulating nausea.

Mood Disorders- Acute Effects of a Single, Oral dose of d9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) Administration in Healthy Volunteers

  • University of Barcelona
  • 2012

related conditions:

Mood Disorders

Unlike THC, which was shown to have acute behavioural and physiological effects, CBD was proven safe and well tolerated by healthy patients. In fact, while THC was associated with higher risks of anxiety and dysphoria, there were no differences between the CBD and placebo on any negative symptomatic variable.

Neurodegeneration & CBD Research Overview

We’ve learned a lot about the power of CBD to control various issues over the last 15 years. It wasn’t all that long ago that most people had no idea what CBD even was, let alone how effective a treatment it can be. Luckily, researchers have continued to publish peer-reviewed studies that highlight the full range of possible applications, including for general neurodegeneration.

CBD has been shown by several different teams to have distinct neuroprotective properties. For instance, a report out of the University of Naples called Cannabidiol: a promising drug for neurodegenerative disorders?, reviewed all the research looking into this possible connection. The team concluded CBD is a promising option for those looking to protect against various neurodegenerative diseases, mainly thanks to its lack of psychoactive side-effects.

Another study, called Transdermal delivery of cannabidiol attenuates binge alcohol-induced neurodegeneration in a rodent model of an alcohol use disorder, concluded many of the same things. Their study sought to provide preclinical data supporting the use of CBD for neurodegeneration. They used a CBD gel on rat models and noted a nearly 50% drop in the rate of neurodegeneration alongside increased neuroprotection. Researchers concluded transdermal CBD could be a viable strategy for reducing alcohol-induced neurodegeneration.

While we have plenty of reports highlighting the power of CBD to slow neurodegeneration, some researchers are now focusing on how this benefit works. The researchers behind Cannabidiol for neurodegenerative disorders: important new clinical applications for this phytocannabinoid? made some important discoveries about how CBD impacts the body. The experiments confirmed CBD leads to the activation of many additional metabotropic receptors via the endocannabinoid system. As such, they believe CBD could one day soon be a significant part of treatment plans for neurodegeneration.

Another study also provided some of the answers to the question. Cannabidiol normalizes caspase 3, synaptophysin, and mitochondrial fission protein DNM1L expression levels in rats with brain iron overload: implications for neuroprotection analyzed the various expressions of brain proteins used in important processes. The team found that treatment with CBD significantly reduced iron-induced neurodegeneration. They concluded iron affected mitochondrial dynamics and CBD could have a large role to play in the development of neuroprotective medicines.

There are several other, less direct, ways in which CBD has been able to help those living with a neurodegenerative disorder. Memory loss is one of the most common issues associated with any neurodegeneration. However, Memory-rescuing effects of cannabidiol in an animal model of cognitive impairment relevant to neurodegenerative disorders concluded that starting a regimen of CBD greatly improved the recognition memory of rat models. The team believes their data suggests CBD could be a powerful treatment option for mitigating cognitive decline and must be studied further.

Another common problem for those with a neurodegenerative disorder that can significantly impact the quality of life is anxiety. That said, CBD has been shown many times to be a potent anti-anxiety medication. In fact, the researchers behind Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence, analyzed over 1500 studies before concluding CBD is the single most effective plant-based treatment for anxiety we have.

Some who develop a neurodegenerative disorder will struggle with mood swings and personality changes. While CBD hasn’t been shown to reduce the chances of this, researchers have long-established CBD is extremely well-tolerated in humans. Reports such as Acute Effects of a Single, Oral dose of d9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) Administration in Healthy Volunteers, have suggested CBD is a much more viable treatment for neurological disorders. This is mainly because it doesn’t increase the risk of anxiety or dysphoria, like THC can.

CBD has also been shown to be a powerful treatment for nausea. Nausea is a relatively common issue associated with many neurodegenerative disorders or their treatments. However, Interaction between non-psychotropic cannabinoids in marijuana: effect of cannabigerol (CBG) on the anti-nausea or anti-emetic effects of cannabidiol (CBD) in rats and shrews, has not only shown CBD reduces nausea but identified one of the primary receptors at play. The researchers concluded moderate doses of CBD activates the 5-HT1A receptors, moderating symptoms.

Best CBD for Neurodegeneration

Everyday Optimal CBD Oil Tincture (4000mg)

Everyday Optimal CBD Oil Tincture (4000mg)

description

CBD oil comes in many forms and potencies, but we haven’t seen any product sold by our competitors as powerful as our 4000mg cbd oil tincture. We make this powerful hemp oil product for people who demand fast, sure-fire relief from severe symptoms.

$289.99
  • CBD Per Serving: 133.33mg
  • Number Of Servings: 30
  • Cost Per Serving: $9.67
  • Cost Per/mg of CBD: $0.07
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advantages

  • Fast Effective Relief
  • Zero THC
  • Made In USA
  Servings per day Days supplied in one package Cost per week
Low Dosage (500 mg/day) 3.75 8.0 $253.75
Mid Dosage (800 mg/day) 6.00 5.0 $406.00
High Dosage (1000 mg/day) 7.50 4.0 $507.50

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Relax Full Spectrum CBD Oil (3500mg)

Relax Full Spectrum CBD Oil (3500mg)

description

Relax Full Spectrum CBD Oil, available with an oil tincture dropper, delivers the ideal amount of CBD to meet all of your wellness needs. Made in the USA  from 100% high quality industrial hemp, this 3500 mg bottle of CBD is perfect for those wanting to combat stress, anxiety, and chronic pain.

$168.00
  • CBD Per Serving: 116.67mg
  • Number Of Servings: 30
  • Cost Per Serving: $5.60
  • Cost Per/mg of CBD: $0.05
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advantages

  • 100% Hemp Product
  • Made in USA
  • Full Spectrum
  Servings per day Days supplied in one package Cost per week
Low Dosage (500 mg/day) 4.29 7.0 $168.00
Mid Dosage (800 mg/day) 6.86 4.4 $268.79
High Dosage (1000 mg/day) 8.57 3.5 $335.99

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Diamond CBD Full Spectrum Honey Tincture (2500mg)

Diamond CBD Full Spectrum Honey Tincture (2500mg)

description

These tasty new honey tinctures are made of 100% all-natural honey, presenting a delicious addition to how to deliver you with the ideal amount of CBD. Available in strengths ranging from 25mg to 3500mg, add it to your morning coffee, tea, or just use it throughout the day to sweeten up every moment while enjoying all of the awesome benefits that CBD offers.

$128.00
  • CBD Per Serving: 83.33mg
  • Number Of Servings: 30
  • Cost Per Serving: $4.27
  • Cost Per/mg of CBD: $0.05
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advantages

  • Honey Flavor
  • Control Over Dosing
  • All Natural Ingredients
  Servings per day Days supplied in one package Cost per week
Low Dosage (500 mg/day) 6.00 5.0 $179.21
Mid Dosage (800 mg/day) 9.60 3.1 $286.73
High Dosage (1000 mg/day) 12.00 2.5 $358.41

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Suggested CBD Dosage for Neurodegeneration

Dosage Per Day

Low

500 mg

Mid

800 mg

High

1000 mg

We're often asked what the ideal dosage needed to treat a variety of conditions is. We wish that it were that simple, and we could provide a basic answer for each situation and call it a day. However, people are much more complicated than that, and what works for one person may not be right for the next.

While we can't offer a precise answer, we can provide a starting point to begin your experimentation. Experts believe that around 5mg of CBD per pound a day is a stable place to start for those looking to prevent neurodegeneration. However, this is no small amount of CBD, as the average person should, by that measure, be taking about 1000mg of CBD per day.

As CBD becomes more and more popular, it's essential to keep in mind that while it's become pervasive in most parts of the country, it's not legal everywhere. In fact, there are still places that treat THC and CBD as essentially the same. Just make sure to research before taking any CBD with you when you travel.

It's also important to talk about the fact that not all CBD products will be THC free. This is because people find that a bit of THC still mixed with the CBD product can significantly increase benefits. However, if you're not able to be impaired, it's important only to use THC-free products.

CBD can be quite mysterious, and sharing our experiences with one another can be a significant way to clear things up. Whichever way you're taking CBD, we hope you'll consider leaving your experience here for others to read and be inspired. By sharing our stories, we make an arduous journey that much more easy for the next people who need it bad.

Tracking CBD Effectiveness For Neurodegeneration

Something we see quite often is people having trouble determining exactly how well CBD is working for them at first. While it can be very frustrating, it’s important to remember that it happens to most people, and it’s just part of the process. CBD has a relatively subtle impact on most conditions, and so determining precisely what it’s doing for you can take a little bit of experimentation and attention.

We suggest to anyone who is having this problem to start keeping track of their daily doses and symptoms in a journal. We’ve yet to find anyone who committed to this plan and didn’t come out, feeling at least somewhat better equipped to answer if CBD works for them or not. If you’re going through the trouble of buying CBD, why not do everything you can to maximize effectiveness?

Sharing information and reading it online has a lot of value, but at the end of the day, each person has a unique system that may require a slightly different routine to maximize things. That’s why it’s so important to invest the time yourself and determine how CBD is working for you personally, not just what it says online. The only way to do this is by paying close attention to what your body is telling you.

Lots of people wonder if keeping this journal is something that must be done to increase the chances of success. While, of course, it’s possible to be successful without any real tracking, we firmly believe nothing is a quicker and easier way to increase your understanding than this.

Whatever you decide to do, we do hope you choose to leave your experiences here for others to benefit from. To do this, all it takes is a short description of how CBD worked for you, along with a score for its effectiveness at treating any memory loss, mood changes, and anxiety. By working together, we can provide a valuable set of information to the next people who need it.

Written By
John Mace Alois is lead content creator at the Did CBD Work? project. He’s analyzed over 400 research papers related to Cannabidiol and helped publish over 55 works related to different conditions for the project. He majored in Cultural Anthropology, with a minor in English, from the University at Albany. He is an avid collector of art supplies and refurbishes old furniture in his spare time.

1 CBD Experience From Neurodegeneration Suffers

    Sundus Jaber

    • May 20, 2020
    So I have multiple conditions. I have PCOS, Hypothyroidism, depression, insomnia, PTSD and was diagnosed with fibromyalgia but now my doctors are not sure but I do have nerve damage and a family history of neurological issues. CBD literally helped with all of these more than my prescriptions without the worry of side effects and dependence which came with my antidepressants and prescription painkillers. 100 mg really made me feel like a normal human being and it was so freeing but I can not afford it regularly, so I take 50 mg on my bad days.

    effectiveness:

    Also effective for:

    • Anxiety
    • Mood Disorders
    • Nausea

    dosage:

    50

    CBD Type:

    CBD Isolate

    How Did You Take It?:

    Pill

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