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Neuropathic Pain overview

When either trauma or disease has impacted the sensory system, affected nerves can no longer work properly, leading to a wide range of issues. For some, this means numbness, but others will have the opposite experience and start having what is known as neuropathic pain.

Neuropathic pain is usually described as an intensely sharp or burning pain. For many people, this pain will go away on its own, but for others, this is a chronic issue that requires intervention. The severity and location of the pain can vary quite a bit from case to case, or even for the same person.

The vast majority of neuropathic pain is a result of nerve damage or an abnormal nervous system. This nerve damage can have a significant impact on not only nerve function, but also pain found in the general area. Neuropathic pain can be quite mysterious, as conditions such as phantom limb syndrome exemplify.

This is a prime example of how pain is not always the direct result of an active injury, but rather the remaining nerves. In rare cases, patients who have lost an arm or leg report still receiving pain signals to the brain as if the affected limb were still there. Generally speaking, the nerves that were originally carrying a pain signal from the limb to the brain start misfiring and causing the sensation of pain.

When not the result of some obvious trauma, the cause of neuropathic pain can often be challenging to pinpoint, that said, some common causes of neuropathic pain include chronic alcohol abuse, diabetes, HIV/AIDS, and chemotherapy. Others will experience pain as a result of arthritis in the spine, shingles, or even syphilis.

Risk factors for neuropathic pain include anything which reduces the functionality of nerves in the body. This includes conditions such as carpal tunnel syndrome, which commonly leads to chronic pain. Other issues that can increase your risk include diabetes, various forms of cancer, stroke, MS, or even vitamin deficiencies.

Neuropathic pain is a widespread issue, with reports suggesting as many as one in every ten adults over the age of 30 is currently living with neuropathic pain at least some of the time. This risk increases even further at 50 and is most commonly found in the lower back, neck, or lower limbs.

Neuropathic pain is a severe problem for many people that significantly impacts their quality of life. While for some, it may remain relatively mild most of the time, for others, it can affect almost every aspect of their lives. If you believe you or a loved one could be suffering from neuropathic pain, please talk to your doctor as soon as possible. Only a professional can get you on the right path forward to a better life.

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Table of Contents

CBD Research For Neuropathic Pain

potencial impact research overview

Neuropathic Pain - Meta-analysis of Cannabis Based Treatments for Neuropathic and Multiple Sclerosis-Related Pain

  • PharmIdeas Research & Consulting
  • 2007

related conditions:

Neuropathic Pain

The authors of this review summarized the efficacy and safety data of cannabinoid-based drugs to assess their potential for treating neuropathic pain. Researchers analyzed the safety and efficacy of various cannabis-based drugs, while also assessing their impact on pain scores. They found that cannabinoids, particularly CBD/THC-based drugs, have been demonstrated to be effective in the treatment and management of neuropathic pain.

Neuropathic Pain - Sativex: Clinical Efficacy and Tolerability in the Treatment of Symptoms of Multiple Sclerosis and Neuropathic Pain

  • Hunters Moor Regional Neurological Rehabilitation Centre
  • 2006

related conditions:

Neuropathic Pain

Researchers sought to understand the impact Sativex, a cannabinoid-based THC/CBD oromucosal spray, may have on helping to manage neuropathic pain. They found that Sativex is both efficacious and well-tolerated in the treatment of a variety of neuropathic conditions. They conclude that if their results can be replicated, Sativex shows great promise as a potential treatment for neuropathic pain.

Neuropathic Pain - Cannabis, Pain, and Sleep: Lessons From Therapeutic Clinical Trials of Sativex, a Cannabis-Based Medicine

  • GW Pharmaceuticals
  • 2007

related conditions:

Neuropathic Pain

This review examines modern studies on the effects that THC and CBD may have on sleep, while also reporting new information on the impact of sleep in the context of neuropathic pain. They found that a 1:1 THC/CBD-based medicine, Sativex, improved subjective sleep parameters in patients suffering from a variety of pain conditions. While additional long-term safety studies are recommended, Sativex has been demonstrated to be effective and well-tolerated in studies extending as far as four years.

Neuropathic Pain - Sativex Successfully Treats Neuropathic Pain Characterised by Allodynia: A Randomised, Double-Blind, Placebo-Controlled Clinical Trial

  • University of Liverpool
  • 2007

related conditions:

Neuropathic Pain

For this study, researchers evaluated the effect of Sativex on pain and allodynia in patients with peripheral neuropathic pain. They observed improvements in the patient's Neuropathic Pain Scale composite scores, sleep NRS, dynamic allodynia, punctate allodynia, Pain Disability Index, as well as the Patient's Global Impression of Change. Not only that, but these results were maintained without dose escalation or toxicity concerns for an additional 52 weeks in an open-label extension study.

Neuropathic Pain - Cannabinoids for Neuropathic Pain

  • University of Utah
  • 2014

related conditions:

Neuropathic Pain

Researchers found that exogenous non-psychoactive cannabinoids such as CBD have been repeatedly demonstrated to be effective in a range of experimental neuropathic pain models, with evidence mounting for their therapeutic use in treating human neuropathic conditions. The authors recommend additional research go into these cannabinoids for the potential as a novel treatment for managing neuropathic pain.

Neuropathic Pain - Neuropathic Orofacial Pain: Cannabinoids as a Therapeutic Avenue

  • University College Cork
  • 2014

related conditions:

Neuropathic Pain

In this review, the authors investigate the potential use of cannabinoids in the treatment and management of symptoms associated with neuropathic orofacial pain. They note the analgesic properties of cannabinoids, and that multiple studies have demonstrated their safety and efficacy in the treatment of neuropathic pain. The authors recommend additional research into the development of a cannabinoid-based drug for the treatment of neuropathic pain.

Neuropathic Pain - Vanilloid TRPV1 Receptor Mediates the Antihyperalgesic Effect of the Nonpsychoactive Cannabinoid, Cannabidiol, in a Rat Model of Acute Inflammation

  • University of Milan-Bicocca
  • 2004

related conditions:

Neuropathic Pain

Researchers examine the antihyperalgesic effect of CBD could be mediated by CB1, CB2, or TRPV1 receptors. Using rat models, they found that modulation of the TRPV1 receptor influenced this effect, with little observed in the other receptors. In their conclusion, they note that the TRPV1 receptor may be a molecular target of CBDs antihyperalgesic effect.

Neuropathic Pain - Antihyperalgesic Effect of a Cannabis Sativa Extract in a Rat Model of Neuropathic Pain: Mechanisms Involved

  • University of Milano-Bicocca
  • 2008

related conditions:

Neuropathic Pain

This study sought to create a case for the development of cannabinoid-based drugs in the treatment of neuropathic pain. Using rat models, researchers found that formulations containing ratios of varying cannabinoids, as opposed to single cannabinoid drugs, offered better antinociceptive efficacy in neuropathic pain. These results demonstrate the therapeutic potential of cannabinoid-based medicines in the treatment and management of neuropathic pain.

Neuropathic Pain - Non-psychoactive Cannabinoids Modulate the Descending Pathway of Antinociception in Anaesthetized Rats Through Several Mechanisms of Action

  • Second University of Naples
  • 2011

related conditions:

Neuropathic Pain

For this experiment, researchers test two non-psychoactive cannabinoids, CBD and CBC, for their antinociceptive effect. Using rat models, the team found that both CBD and CBC were effective in inducing antinociceptive responses. In their results, the authors conclude that CBD and CBC stimulated antinociception and caused analgesia, showing potential as a therapeutic agent using multiple mechanisms of action.

Neuropathic Pain - Cannabinoids Suppress Inflammatory and Neuropathic Pain by Targeting α3 Glycine Receptors

  • National Institutes of Health
  • 2012

related conditions:

Neuropathic Pain

The authors of this study report that the administration of CBD and related synthetic analogs significantly suppress chronic inflammation and neuropathic pain without causing analgesic tolerance in rat models. Their findings suggest that cannabinoid-based formulations may be useful in suppressing chronic pain. They also conclude that cannabinoids may be a novel class of therapeutic agents in the treatment and management of chronic pain.

Neuropathic Pain - Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes

  • Miguel Hernandez University
  • 2007

related conditions:

Neuropathic Pain

This review explores the endocannabinoid system and cannabinoid-based medications, as well as their mechanisms of action. Through their work, the authors highlight the repeated demonstrated efficacy and safety of using cannabinoid-based medicines in the treatment and management of neuropathic pain and associated conditions. The authors recommend further clinical trials to evaluate potential applications of cannabinoid-based medications as novel therapeutic drugs for helping to manage pain.

Neuropathic Pain - Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study of the Efficacy, Safety, and Tolerability of THC:CBD Extract and THC Extract in Patients With Intractable Cancer-Related Pain

  • Severn Hospice
  • 2010

related conditions:

Neuropathic Pain

In this study, researchers compare the efficacy of a THC:CBD extract against a THC extract in relieving pain in patients facing advanced cancer. In their findings, the THC:CBD extract performed significantly better than the THC extract alone in improving the suffering of patients. The authors conclude that a THC:CBD extract is effective and well-tolerated for relieving pain in patients with advanced cancer not mitigated by opioids.

Neuropathic Pain - Marijuana extract helps prevent chemo pain

  • Temple University
  • 2011

related conditions:

Neuropathic Pain

The author of this article reviews a 2011 study on the effects of administering CBD to treat neuropathy caused by chemotherapy. The study’s results showed that CBD pretreatment before chemotherapy effectively prevented abnormal pain development, which may be permanent. There was no evidence of neuropathy even after pretreatment had ended. The author notes that while these results are promising, additional research is needed to evaluate the effects and underlying mechanisms using human models.

Neuropathic Pain - Pot Users Less Likely to Take Painkillers

  • Ameritox
  • 2013

related conditions:

Neuropathic Pain

This study by a drug screening company reviews potential nonadherence to patients prescribed opioids. Their findings indicated that consumers of cannabis actually ended up not taking their opioid medications, through the testing of urine samples that detected cannabinoids but not opioids. Their results suggest that cannabis users find effective and well-tolerated pain relief as opposed to those prescribed opioids.

Multiple Sclerosis - Oromucosal delta9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, open-label, 2-year extension trial

  • Walton Centre for Neurology and Neurosurgery
  • 2007

related conditions:

Multiple Sclerosis

Central neuropathic pain is one of the most common symptoms caused by any dysfunction in the nervous system. CBD was tested as a potential method for reducing pain without adverse side effects. CBD was shown to be an effective treatment option even after two years of doses, as there was no evidence of increased tolerance.

Parkinson's- The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain

  • University of Milano-Bicocca
  • 2007

related conditions:

Neuropathic Pain

Researchers wanted to take a deeper look at the anti-inflammatory and immunomodulatory effects of CBD. CBD was administered to rat models daily for two weeks, which resulted in very promising results. The team noted reduced hyperalgesia, which they attributed to a vanilloid antagonist. As such, they believe CBD has the potential to be therapeutic for chronic pain conditions.

Parkinson's- Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT(1A) receptors without diminishing nervous system function or chemotherapy efficacy

  • Temple University School of Medicine
  • 2014

related conditions:

Neuropathic Pain

The research concluded CBD provides a protective effect against Paclitaxel induced neurotoxicity in cancer patients. The study indicated CBD doesn’t harm either nervous system function or chemotherapy efficacy. The team also assessed the impact of CBD on several distinct factors, including place conditioning and cancer cell viability.

Parkinson's- Cannabinoids in the management of difficult to treat pain

  • GW Pharmaceuticals
  • 2008

related conditions:

Neuropathic Pain

This review of the available evidence suggests CBD and the endocannabinoid system could play an integral role in pain treatment. Not only do clinical trials show CBD is well-tolerated, but a growing number of researchers agree on their value. Repeated randomized trials have shown CBD based medications are safe and effective in treating central and peripheral neuropathic pain.

CBD Research That Might Be Useful for Symptoms of Neuropathic Pain

potencial impact research overview

Anxiety - Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence

  • University of Melbourne, Australia
  • 2013

related conditions:

Anxiety

A comprehensive review of all the plant-based medicine which has had both preclinical and human clinical trials conducted about their anxiolytic-like effect. An analysis of over 1500 papers identified 21 plants which had been adequately tested, with one of the most successful of these plants found to be CBD enriched Cannabis species.

Inflammation - Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice

  • Tongji University School of Medicine
  • 2013

related conditions:

Inflammation

A study of mice concluded CBD has significant anti-inflammatory effects. The researchers also saw evidence that the expression of the GPR55 receptor was improved after starting on CBD. Treatment with CBD was shown to significantly decrease the levels of several inflammation-related chemicals in test subjects.

Pain Relief - Control of pain initiation by endogenous cannabinoids

  • University of Naples Federico II
  • 1998

related conditions:

Pain ReliefSkinSkin Conditions

Researchers concluded CBD significantly reduces discomfort and pain, in part, due to the interaction between two substances, PEA and anandamide. According to tests, they “act synergistically, reducing pain responses 100-fold more potently than each compound alone”.

Neuropathic Pain & CBD Research Overview

Of all the things CBD has been shown to potentially improve over the last 20 years, few have more backing them than a reduction in neuropathic pain. It wasn’t all that long ago, very few people knew about the incredible benefits of CBD for those living with this debilitating pain. However, these days thousands of people are finding out every day just what CBD can do for them.

Researchers have long searched for new and effective treatments for neuropathic pain. As such, the researchers behind Meta-analysis of Cannabis Based Treatments for Neuropathic and Multiple Sclerosis-Related Pain wanted to review the available data to determine how safe and effective it really is. They concluded cannabinoids, but especially CBD based drugs have a powerful effect on the treatment of debilitating neuropathic pain.

Another report, called Cannabinoids for Neuropathic Pain, showed that CBD could be effective for a range of different pain-related disorders. They noted the mounting evidence proving the therapeutic uses of CBD in humans. The team believed that while their data provides a solid starting point, further inquiry is needed to understand the effect fully.

Other reviews of the research have come to similar conclusions about the applications of CBD. For instance, Neuropathic Orofacial Pain: Cannabinoids as a Therapeutic Avenue showed treatment with CBD could significantly reduce orofacial related neuropathic pain. As with other teams, they concluded not only is CBD effective but very well tolerated, even in high doses.

The movement to develop CBD-based medications for neuropathic pain has been growing for at least the last ten years. Research such as Antihyperalgesic Effect of a Cannabis Sativa Extract in a Rat Model of Neuropathic Pain: Mechanisms Involved, going back to 2008, observed the impact of CBD on neuropathic pain. They used rat models to show combinations of several cannabinoids with the CBD is much more effective than any cannabinoid alone.

This compounded effect has been observed by other researchers. Control of pain initiation by endogenous cannabinoids concluded that CBD medications, which include both PEA and anandamide, are 100-fold more effective than either substance would be on their own. This powerful benefit has even been harnessed into an FDA approved drug.

There’s been a lot of research on Sativex, a CBD based prescription drug, most commonly used to regulate treatment-resistant forms of epilepsy. However, one of the most potent effects Sativex has been shown to have in many reports is its pain-reducing properties.

Research looking into the impact of Sativex, such as Sativex: Clinical Efficacy and Tolerability in the Treatment of Symptoms of Multiple Sclerosis and Neuropathic Pain, have provided robust results. Not only was Sativex well-tolerated, but it was effective in regulating neuropathic disorders and reducing neuropathic pain.

Other reports, such as Cannabis, Pain, and Sleep: Lessons From Therapeutic Clinical Trials of Sativex, a Cannabis-Based Medicine, and Sativex Successfully Treats Neuropathic Pain Characterised by Allodynia: A Randomised, Double-Blind, Placebo-Controlled Clinical Trial have also provided incredible results. They were able to show CBD-based Sativex increased quality of sleep for those with debilitating neuropathic pain, as well as dramatically reducing patient’s Neuropathic Pain Scale scores, all without requiring increasing dosages.

CBD treatment has also been shown to help control cancer or chemotherapy-related neuropathic pain. A report called, Multicenter, Double-Blind, Randomized, Placebo-Controlled, Parallel-Group Study of the Efficacy, Safety, and Tolerability of THC:CBD Extract and THC Extract in Patients With Intractable Cancer-Related Pain, indicated CBD medications which still contain a bit of THC may provide a more potent effect on neuropathic pain than CBD alone.

Reviews of the data on CBD and chemo-related pain have provided some promising results. A 2011 study of the information called Marijuana extract helps prevent chemo pain, showed pretreatment with CBD was so effective it could even potentially prevent any abnormal pain from developing as a result of chemotherapy. Even more impressively, there were no signs of neuropathy, even after the pretreatment had worn off. This long-lasting impact has also been shown in other reports, including Oromucosal delta9-tetrahydrocannabinol/cannabidiol for neuropathic pain associated with multiple sclerosis: an uncontrolled, open-label, 2-year extension trial.

Further reports on CBD and reducing cancer-related pain, such as Cannabidiol inhibits paclitaxel-induced neuropathic pain through 5-HT(1A) receptors without diminishing nervous system function or chemotherapy efficacy, have yielded promising information. They observed that CBD treatment not only improves pain but doesn’t reduce the effectiveness of the chemo or harm the nervous system in any way.

There’s a lot of research indicating the power of CBD to help control neuropathic pain. In addition to the studies already mentioned, Cannabinoids Suppress Inflammatory and Neuropathic Pain by Targeting α3 Glycine Receptors showed CBD, and even its synthetic analogs can dramatically reduce inflammation and subsequent neuropathic pain.

One thing that’s very well-proven about CBD is how well tolerated it is in humans. Reports such as Role of the Cannabinoid System in Pain Control and Therapeutic Implications for the Management of Acute and Chronic Pain Episodes and Cannabinoids in the management of difficult to treat pain have been able to prove that not only is CBD an effective potential treatment for neuropathic pain, but prove beyond the shadow of a doubt that it’s safe for humans.

While we still don’t know a ton about what causes this effect, some researchers have started to uncover parts of the mystery. For example, the team behind Vanilloid TRPV1 Receptor Mediates the Antihyperalgesic Effect of the Nonpsychoactive Cannabinoid, Cannabidiol, in a Rat Model of Acute Inflammation, identified the TRPV1 receptor as a primary influencer, having minimal interaction with other receptors.

Other researchers have suggested additional cannabinoids could bolster the effects of CBD. This includes Non-psychoactive Cannabinoids Modulate the Descending Pathway of Antinociception in Anaesthetized Rats Through Several Mechanisms of Action, which showed CBD and CBC could significantly control the level of neuropathic pain, via antinociception and analgesia.

Another possible way in which CBD can control neuropathic pain was identified by the researchers behind The non-psychoactive cannabis constituent cannabidiol is an orally effective therapeutic agent in rat chronic inflammatory and neuropathic pain. The team showed CBD administration to rat models over the course of two weeks was able to reduce hyperalgesia dramatically. They concluded this effect was due to an interaction with vanilloid antagonist interactions. The team believes further research is needed to tease out the full benefits of CBD.

Outside of the direct benefits for those living with neuropathic pain, researchers have shown other ways CBD could be a useful tool. A report called, Pot Users Less Likely to Take Painkillers, reviewed drug screenings of patients who had been prescribed opioids. The team showed that those who used cannabinoids such as CBD and THC are more likely to not need their opioid medication for as long. The researchers believe this highlights how CBD could someday soon be a vital tool in the control of not only neuropathic pain but pain throughout the body.

Many who deal with neuropathic pain will also have general inflammation in various parts of their body — as such, having effective and well-tolerable treatment options are vital. That said, Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice provides plenty of evidence that CBD does exactly that. The team showed CBD can greatly reduce inflammation via an interaction with the GPR55 receptors.

Anxiety is another very common problem for people who face debilitating chronic pain. Luckily, CBD is well-known as a powerful anti-anxiety medication. In fact, Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence, looked at over 1500 studies before determining CBD is the best plant-based anxiety treatment we currently have at our disposal.

Best CBD for Neuropathic Pain

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description

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$299.99
  • CBD Per Serving: 200mg
  • Number Of Servings: 30
  • Cost Per Serving: $10.00
  • Cost Per/mg of CBD: $0.05
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  • THC Free
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Pure CBD Oil Capsules, (50mg)

Pure CBD Oil Capsules, (50mg)

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Suggested CBD Dosage for Neuropathic Pain

Dosage Per Day

Low

15 mg

Mid

30 mg

High

50 mg

We’re asked all the time what the precise amount of CBD needed to improve a given condition, such as neuropathic pain. It would be ideal if we could simply offer the right answer for everyone, but it sadly doesn’t work like that. There are far too many variables at play to ensure that the same amount of CBD will work for everyone in the same way.

That said, we still can provide a basic answer that you can then build off of based on your specific needs. According to reports, between 20-40mg per day is a reliable place to start for neuropathic pain. Researchers suggest taking more on severe pain days and less on more mild ones, but overall increasing dosages slowly over time until they find an ideal range.

CBD is very common around the country these days, often found in all sorts of chic shops and products. However, it’s actually still illegal in several places, making keeping track of local laws relevant. Just do your due diligence, and you shouldn’t run into any problems while traveling.

We should also mention that not all CBD products are non-psychoactive. In fact, some CBD products still contain a fair bit of THC to increase its effectiveness. Many report this having a benefit for several conditions, but it’s essential to keep in mind if you can’t be impaired. In that case, you have to make sure only to buy THC-free products.

Whichever way you end up taking your CBD, you should seriously consider leaving your experiences here for the next person to learn from. When people are first starting, it can be extremely challenging to determine what the right path forward is. By offering up our experiences, we can ensure the journey is that much easier for the newcomers.

Tracking CBD Effectiveness For Neuropathic Pain

A very common problem those starting on CBD face is trouble nailing down precisely how well it's working for them. This can definitely be a very frustrating problem, but most people deal with this as part of the process. CBD has a relatively subtle impact making it much more difficult to know how well it's working right away. What it really takes is trying different things and paying attention to how your system reacts.

If you're facing this problem and are looking for the solution, there's not much better advice we have than keeping a simple journal of your experiences and dosages. By simply tracking your daily dosages and subsequent symptoms, most people can establish precisely how well CBD is working for them in just a few weeks. You owe it to yourself to try everything you can to maximize the chances CBD improves your symptoms.

While reading about other's experiences online is an incredible tool, at some point, you have to do the experimentation for yourself. Each one of us will react slightly differently to a new regimen, so the only way to truly maximize the effectiveness is by paying attention to your body and adjusting dosages as you go.

We're often asked if keeping a journal is a vital part of this process. While it's true that you could be happy with what CBD is doing for you without tracking it, you'll never know if it could be even better. This simple trick is by far the easiest way we've found to make the most out of any CBD product you purchase.

We hope you choose to leave your experience here for others to learn from regardless of how you want to track your progress. The more information newcomers have at their disposal, the easier the transition period will be. All you need to do is provide a brief description of your time taking CBD along with a score for how well it improved any pain, trouble sleeping, and anxiety.

1 CBD Experience From Neuropathic Pain Suffers

    Kiri

    • May 6, 2020
    I use CBD for pain relief and to control inflammation. Vaping gives me quick acting relief from flares of joint pain and dislocations caused by my condition and also helps control some respiratory symptoms from my mast cell issues. Would definitely recommend it!

    effectiveness:

    Also effective for:

    • Anxiety
    • Inflammation
    • Pain Relief

    dosage:

    100

    CBD Type:

    CBD Isolate

    How Did You Take It?:

    Vape

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