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Parkinson's overview

Parkinson’s disease is a debilitating condition which affects the brain and its ability to control movement. While it typically occurs in elderly people, it’s also found in younger adults. Regardless of how old you are when you develop Parkinson’s, it can significantly reduce your overall quality of life.

While what causes this condition is still a mystery, experts know the symptoms are a result of gradual degeneration in the nerve cells which control movement. For many, the first signs can be as innocuous as mild stiffness or acute hand tremors.

Movement is controlled by the basal ganglia, which requires a delicate balance of chemicals to send signals to the body. Experts believe Parkinson’s causes the degeneration of cells which provide some of these substances, throwing off the overall balance. The full extent of this relationship is still being researched, but evidence indicates that Parkinson’s may be related to other neurological conditions, such as Alzheimer’s, Creutzfeldt-Jakob disease, Huntington’s disease, and more.

According to experts, the precise cause of the vast majority of Parkinson’s cases is unknown; However, they do have some leads. One of the primary risk factors for Parkinson’s disease we know is genetics. While not all cases have a genetic component, many do. Other causes are things as varied as viral infections or even exposure to toxins, such as carbon monoxide.

While not an extremely common condition, it does affect a significant number of people worldwide. Sixty thousand people are diagnosed with Parkinson’s every year in America, with an estimated 10 million affected around the globe.

If you’re worried you or a loved one may be experiencing the early signs of Parkinson’s disease, be sure to make an appointment with your doctor as soon as possible. Only a professional can properly diagnose and treat conditions such as Parkinson’s

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Table of Contents

CBD Research For Parkinson's

potencial impact research overview

Parkinson's- Effects of cannabidiol in the treatment of patients with Parkinson's disease: an exploratory double-blind trial

  • University of Sao Paulo
  • 2014

related conditions:

Parkinson’s Disease

The research confirmed CBD could be an effective treatment for neurological degeneration. Interestingly, they found evidence suggesting CBD could significantly improve the quality of life for those living with debilitating neurological conditions. While they believe more research is needed, this report provides ample reason to look deeper into the impact of CBD.

Parkinson's- Prospects for cannabinoid therapies in basal ganglia disorders

  • University Institute of Research in Neurochemistry
  • 2011

related conditions:

Parkinson’s Disease

The team concluded CBD has antioxidant properties in relation to several neurological conditions. Research finds that activation of the CB2 receptor could soon be a viable option for treatment of neurologically degenerative disorders. They observed ample evidence suggesting the neuroprotective properties to warrant further clinical evaluation.

Parkinson's- Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties

  • Complutense University
  • 2007

related conditions:

Parkinson’s Disease

The study indicates CBD has valuable neuroprotective properties which can be leveraged to fight against several degenerative disorders. CBD was shown to provide this benefit via an antioxidant effect which researchers believe needs to be studied more closely. Interestingly, CBD was shown to provide a more significant benefit when administered on a regular basis, early on in development.

Parkinson's- Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's disease

  • Complutense University
  • 2005

related conditions:

Parkinson’s Disease

Research shows CBD has neuroprotective properties, especially in regards to acute and chronic neurodegeneration. The study found evidence which suggests this neuroprotective benefit is provided thanks to the antioxidant properties of CBD. Their testing concluded CBD increased cerebellar cell survival after exposure to toxic 6-hydroxydopamine.

Parkinson's- Cannabidiol for the treatment of psychosis in Parkinson's disease

  • University of Sao Paulo
  • 2009

related conditions:

Parkinson’s Disease

The team determined CBD is a safe and effective treatment for the psychosis which often accompanies neurological conditions. They gave participants a 150mg oral dose of CBD every day for four weeks along with their standard treatments. The data indicates that not only is CBD effective at treating psychosis, but it does it without any evident adverse side effects.

Parkinson's- Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ⁹-THCV in animal models of Parkinson's disease

  • University Institute of Research in Neurochemistry
  • 2011

related conditions:

Parkinson’s Disease

CBD is shown to provide several benefits thanks to a powerful antioxidant effect. The team found evidence of an ability to activate CB2 receptors while simultaneously blocking CB1 receptors. As such, researchers are optimistic about the ability of CBD to help delay the progression of several debilitating neurological conditions.

Parkinson's- Therapeutic potential of cannabinoids in CNS disease

  • Northwestern University Medical School
  • 2003

related conditions:

Parkinson’s Disease

The team wanted to better understand all the ways in which the endocannabinoid system and CBD can affect the treatment of neurological disorders. They identified several CNS disorders in which CBD was found to provide an improvement. The data suggests not only does CBD counteract oxidative damage, but it may also one day be part of an effective treatment for chronic pain.

CBD Research That Might Be Useful for Symptoms of Parkinson's

potencial impact research overview

Parkinson's- Cannabinoids control spasticity and tremor in a multiple sclerosis model

  • University College London
  • 2000

related conditions:

Restlessness

Their testing confirmed CBD was able to effectively reduce the strength and frequency of tremors and spasticity in test mice. They concluded that interaction with the CB1 and CB2 receptors is the primary culprit of this effect.

Arthritis - Arthritis and cannabinoids: HU‐210 and Win‐55,212–2 prevent IL‐1 α‐induced matrix degradation in bovine articular chondrocytes in‐vitro

  • Royal Pharmaceutical Society of Great Britain
  • 2006

related conditions:

Arthritis

CBD was shown to have “analgesic, immunomodulatory and anti‐inflammatory properties.” Researchers determined a CBD regimen reduces joint damage from arthritis, mainly by strengthening cartilage. They also noted several different ways in which the body reacts favorably to the introduction of CBD, especially in mitigating the degradation and inflammation induced by cytokines.

Sleep - Cannabis, Cannabinoids, and Sleep: a Review of the Literature

  • Palo Alto University, CA, USA
  • 2017

related conditions:

Sleep

This report concludes CBD holds promise for significantly increasing the quality of REM sleep. Researchers believe it could one day be a primary force behind improved overall sleep quality. CBD was even shown to reduce daytime sleepiness in many patients.

Parkinson's & CBD Research Overview

CBD has quickly grown into a massive industry, in part, thanks to the wide range of conditions it's been shown to improve. That said, we're only just starting to uncover everything there is to know about the impact of CBD. For instance, we now believe that CBD could be an effective part of Parkinson's disease treatment strategies.

Parkinson's disease is associated with neurodegeneration which results in less control over movement. CBD has been repeatedly shown to have potent neuroprotective benefits which studies show could benefit those dealing with Parkinson's. One report, called Effects of cannabidiol in the treatment of patients with Parkinson's disease: an exploratory double-blind trial* found ample evidence backing CBD as protecting against neurological degeneration, like that associated with Parkinson's.

Other studies have reached similar conclusions. Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's disease* showed CBD could protect against both acute and chronic neurodegeneration. Their data showed CBD increased the survival rate of brain cells after exposure to substances associated with Parkinson's, such as 6-hydroxydopamine.

But other researchers have started to understand why CBD provides this distinct neuroprotective benefit. Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties* found that CBD provides this benefit thanks to an antioxidant effect. While they believe it must be studied more thoroughly, the team believes it could soon present a viable addition to Parkinson's treatment plans.

As such, other researchers have spent time trying to understand the nature of this antioxidant effect better. A report called, Prospects for cannabinoid therapies in basal ganglia disorders* concluded activation of the CB2 receptor could be central to this impact. Researchers observed significant neuroprotective properties which need to be studied further.

Other studies have looked deeper into the relationship between the CB1 and CB2 receptors and what it means for people dealing with Parkinson's. A report called Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ⁹-THCV in animal models of Parkinson's disease* showed activation of CB1, while blocking CB2, resulted in a slower progression of conditions such as Parkinson's.

While we still don't know enough about the relationship between CBD and Parkinson's, what evidence we do have is quite promising. In fact, Therapeutic potential of cannabinoids in CNS disease* found that CBD can counteract the oxidative damage resulting from several CNS disorders, including Parkinson's.

But what does all this mean for those dealing with Parkinson's disease in their everyday lives? Well, there is no shortage of evidence suggesting CBD can help ease some of the debilitating symptoms of Parkinson's. Cannabidiol for the treatment of psychosis in Parkinson's disease* was a report which found that CBD can help reduce the psychosis which is sometimes known to accompany conditions like Parkinson's.

But one of the most significant ways CBD could one day improve the lives of those with Parkinson's is by reducing the tremors which characterize this disease. Cannabinoids control spasticity and tremor in a multiple sclerosis model* was able to show significant evidence that CBD can reduce both the strength and frequency of muscle tremors in lab mice. Once again, the CB1 and CB2 receptors were believed to be the primary culprit behind this effect, warranting further study.

Another common symptom of those living with Parkinson's is stiff and inflamed joints. Luckily, CBD has also been shown to be an incredibly powerful anti-inflammatory medication by reports such as Arthritis and cannabinoids: HU‐210 and Win‐55,212–2 prevent IL‐1 α‐induced matrix degradation in bovine articular chondrocytes in‐vitro.* The team concluded a regular CBD regimen could significantly reduce joint damage via the strengthening of cartilage.

Finally, as with many debilitating conditions, trouble sleeping can often be a significant problem for people with Parkinson's disease. However, many researchers are optimistic about the ability of CBD to improve REM sleep. One such report is called Cannabis, Cannabinoids, and Sleep: a Review of the Literature*, which not only found CBD improves sleep, but it can also reduce daytime sleepiness as well.

Best CBD for Parkinson's

NoteCBD Capsules (10mg)

NoteCBD Capsules (10mg)

description

Enjoy the benefits of hemp extract with the convenience of a capsule. Each capsule contains a pre-portioned dose of full-spectrum hemp extract and MCT oil.

$45.00
  • CBD Per Serving: 10mg
  • Number Of Servings: 30
  • Cost Per Serving: $1.50
  • Cost Per/mg of CBD: $0.15
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advantages

  • Full Spectrum
  • Lab Certified
  • Organic
  Servings per day Days supplied in one package Cost per week
Low Dosage (5 mg/day) 0.50 60.0 $5.25
Mid Dosage (15 mg/day) 1.50 20.0 $15.75
High Dosage (30 mg/day) 3.00 10.0 $31.50

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NoteCBD Capsules (25mg)

NoteCBD Capsules (25mg)

description

Enjoy the benefits of hemp extract with the convenience of a capsule. Each capsule contains a pre-portioned dose of full-spectrum hemp extract and MCT oil.

$95.00
  • CBD Per Serving: 25mg
  • Number Of Servings: 30
  • Cost Per Serving: $3.17
  • Cost Per/mg of CBD: $0.13
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advantages

  • Full Spectrum
  • Gluten Free
  • Lab Certified
  Servings per day Days supplied in one package Cost per week
Low Dosage (5 mg/day) 0.20 150.0 $4.43
Mid Dosage (15 mg/day) 0.60 50.0 $13.30
High Dosage (30 mg/day) 1.20 25.0 $26.60

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Pure CBD Oil Capsules (15mg)

Pure CBD Oil Capsules (15mg)

description

Every Day Optimal Soft Gel PCR Hemp Oil Capsule contains 15mg pure CBD from our proprietary high CBD strain of hemp.

$59.99
  • CBD Per Serving: 15mg
  • Number Of Servings: 30
  • Cost Per Serving: $2.00
  • Cost Per/mg of CBD: $0.13
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advantages

  • Easy Capsule Form
  • No GMO
  • All Natural
  Servings per day Days supplied in one package Cost per week
Low Dosage (5 mg/day) 0.33 90.0 $4.67
Mid Dosage (15 mg/day) 1.00 30.0 $14.00
High Dosage (30 mg/day) 2.00 15.0 $28.00

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Suggested CBD Dosage for Parkinson's

Dosage Per Day

Low

5 mg

Mid

15 mg

High

30 mg

Probably the most common question we get by far is how much CBD should be taken for a given condition. While it would be perfect if we could just give the precise dosage, the fact is each person is different and there’s no way the same dosages will work for everyone.

That said, the best way to find your ideal dosage is simply by experimenting until you find what works best. This is another way in which keeping a journal can be of a major benefit to you. And since CBD is non-psychoactive, you don’t have to worry about taking too much and ending up impaired.

Despite there not being a perfect dosage for everyone dealing with Parkinson’s, that doesn’t mean we aren’t able to give some insight into where to begin your experimentation. According to a report by Dr. Maureen A. Leehey, Professor of Neurology and Chief of the Movement Disorders Division at the University of Colorado, dosages between 5mg and 20mg per day can provide benefits for those living with Parkinson’s disease.

While CBD has grown into a well-respected medication in many parts of the country, there are still places which treat CBD the same as THC. In these places, you can get in serious trouble if you’re found in possession of CBD products, so always be sure to do your research before traveling with your CBD.

It’s also important to keep in mind that not all CBD products are 100% THC free. In fact, some conditions are known to be more effectively treated when a little THC is still present along with the CBD. As such, you must make sure the products you buy are 100% CBD if you’re looking to avoid any psychoactive side-effects.

Just keep in mind, whatever type of CBD product you buy, the best thing you can do to improve its effectiveness is to keep a journal. It takes a little getting used too, but nothing else can make the transition quite as smooth as staying aware of how CBD is affecting your body.

Tracking CBD Effectiveness For Parkinson's

For most people, it can seem pretty intimidating figuring out how to track the effectiveness of CBD. While it’s true that for many conditions, it can be challenging to notice the effect of CBD right away, Parkinson’s isn’t nearly as bad as others. Since for many, their symptoms are a prevalent part of their everyday lives; any change is usually very noticeable.

Regardless, it’s always constructive to start a journal to track your progress with CBD. Most people are amazed by how much of a difference, simply keeping track of their dosages and symptoms can make in understanding how it impacts you personally. For all the people who are wondering what’s the best way to identify any progress, this is it.

The bottom line is that each person is different and will have a slightly different response to CBD. Not only that, but for most people, it takes a bit of time until their body has fully acclimated to the new medication, and benefits become more evident. With just a few weeks of tracking your progress, you’ll be amazed at how much better you’ll understand how CBD affects you.

If you’re looking to zero in on exactly how CBD works for you or a loved one, be sure to start a journal. It may seem like a small thing to do when dealing with Parkinson’s disease, but if you simply pay attention to how CBD is impacting your tremors, inflammation, and stiffness over a few weeks, it can make a world of difference.

That said, if you do decide to keep track of your progress with CBD, we sincerely hope you consider leaving your experiences here for others looking to improve their quality of life. If you just leave a short description of your time using CBD, along with a score for how well it improved your tremors, inflammation, and stiffness, we can build the world’s strongest resource for people who want to learn about CBD.

Experiences Using CBD for Parkinson's

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