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Parkinson's overview

Published on September 11th, 2019

Last updated on June 6th, 2020

Parkinson’s disease is a debilitating condition that affects the brain and its ability to control movement. While it typically occurs in elderly people, it is also found in younger adults. Regardless of how old you are when you develop Parkinson’s disease, it can significantly reduce your overall quality of life.

While what causes this condition is still a mystery, experts know the symptoms are a result of gradual degeneration in the nerve cells which control movement. For many, tremors at rest are the earliest signs. They can also be unilateral (on one side of the body).

Parkinson disease is associated with the loss of neurons in the basal ganglia (responsible for motor action smoothness and preciseness), which secretes dopamine. Loss of these neurons leads to the three cardinal features of Parkinson’s disease, which are tremors, rigidity, and bradykinesia (slow movement). Experts believe that Parkinson’s disease causes the degeneration of cells that provide some of these actions, thereby throwing off the overall balance. The full extent of this relationship is still being researched. Nevertheless, evidence indicates that Parkinson’s may be related to other neurological conditions, such as Alzheimer’s, Creutzfeldt-Jakob disease, Huntington’s disease, and more.

According to experts, the precise cause of the vast majority of Parkinson’s cases is unknown. However, they do have some leads. One of the primary risk factors for Parkinson’s disease that we know is genetics. While not all cases have a genetic component, many do. Other causes are things as varied as viral infections or even exposure to toxins, such as carbon monoxide.

While not an extremely common condition, it does affect a significant number of people worldwide. Sixty thousand people are diagnosed with Parkinson’s every year in America, with over 6 million persons estimated to suffer from Parkinson’s disease globally.

If you’re worried that you or a loved one may be experiencing the early signs of Parkinson’s disease, be sure to make an appointment with your doctor as soon as possible. Only a professional can accurately diagnose and treat conditions such as Parkinson’s.

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Table of Contents

CBD Research For Parkinson's

potencial impact research overview

Parkinson's- Effects of cannabidiol in the treatment of patients with Parkinson's disease: an exploratory double-blind trial

  • University of Sao Paulo
  • 2014

related conditions:

Parkinson’s Disease

The research confirmed CBD could be an effective treatment for neurological degeneration. Interestingly, they found evidence suggesting CBD could significantly improve the quality of life for those living with debilitating neurological conditions. While they believe more research is needed, this report provides ample reason to look deeper into the impact of CBD.

Parkinson's- Prospects for cannabinoid therapies in basal ganglia disorders

  • University Institute of Research in Neurochemistry
  • 2011

related conditions:

Parkinson’s Disease

The team concluded CBD has antioxidant properties in relation to several neurological conditions. Research finds that activation of the CB2 receptor could soon be a viable option for treatment of neurologically degenerative disorders. They observed ample evidence suggesting the neuroprotective properties to warrant further clinical evaluation.

Parkinson's- Evaluation of the neuroprotective effect of cannabinoids in a rat model of Parkinson's disease: importance of antioxidant and cannabinoid receptor-independent properties

  • Complutense University
  • 2007

related conditions:

Parkinson’s Disease

The study indicates CBD has valuable neuroprotective properties which can be leveraged to fight against several degenerative disorders. CBD was shown to provide this benefit via an antioxidant effect which researchers believe needs to be studied more closely. Interestingly, CBD was shown to provide a more significant benefit when administered on a regular basis, early on in development.

Parkinson's- Cannabinoids provide neuroprotection against 6-hydroxydopamine toxicity in vivo and in vitro: relevance to Parkinson's disease

  • Complutense University
  • 2005

related conditions:

Parkinson’s Disease

Research shows CBD has neuroprotective properties, especially in regards to acute and chronic neurodegeneration. The study found evidence which suggests this neuroprotective benefit is provided thanks to the antioxidant properties of CBD. Their testing concluded CBD increased cerebellar cell survival after exposure to toxic 6-hydroxydopamine.

Parkinson's- Cannabidiol for the treatment of psychosis in Parkinson's disease

  • University of Sao Paulo
  • 2009

related conditions:

Parkinson’s Disease

The team determined CBD is a safe and effective treatment for the psychosis which often accompanies neurological conditions. They gave participants a 150mg oral dose of CBD every day for four weeks along with their standard treatments. The data indicates that not only is CBD effective at treating psychosis, but it does it without any evident adverse side effects.

Parkinson's- Symptom-relieving and neuroprotective effects of the phytocannabinoid Δ⁹-THCV in animal models of Parkinson's disease

  • University Institute of Research in Neurochemistry
  • 2011

related conditions:

Parkinson’s Disease

CBD is shown to provide several benefits thanks to a powerful antioxidant effect. The team found evidence of an ability to activate CB2 receptors while simultaneously blocking CB1 receptors. As such, researchers are optimistic about the ability of CBD to help delay the progression of several debilitating neurological conditions.

Parkinson's- Therapeutic potential of cannabinoids in CNS disease

  • Northwestern University Medical School
  • 2003

related conditions:

Parkinson’s Disease

The team wanted to better understand all the ways in which the endocannabinoid system and CBD can affect the treatment of neurological disorders. They identified several CNS disorders in which CBD was found to provide an improvement. The data suggests not only does CBD counteract oxidative damage, but it may also one day be part of an effective treatment for chronic pain.

CBD Research That Might Be Useful for Symptoms of Parkinson's

potencial impact research overview

Parkinson's- Cannabinoids control spasticity and tremor in a multiple sclerosis model

  • University College London
  • 2000

related conditions:

Restlessness

Their testing confirmed CBD was able to effectively reduce the strength and frequency of tremors and spasticity in test mice. They concluded that interaction with the CB1 and CB2 receptors is the primary culprit of this effect.

Arthritis - Arthritis and cannabinoids: HU‐210 and Win‐55,212–2 prevent IL‐1 α‐induced matrix degradation in bovine articular chondrocytes in‐vitro

  • Royal Pharmaceutical Society of Great Britain
  • 2006

related conditions:

Arthritis

CBD was shown to have “analgesic, immunomodulatory and anti‐inflammatory properties.” Researchers determined a CBD regimen reduces joint damage from arthritis, mainly by strengthening cartilage. They also noted several different ways in which the body reacts favorably to the introduction of CBD, especially in mitigating the degradation and inflammation induced by cytokines.

Sleep - Cannabis, Cannabinoids, and Sleep: a Review of the Literature

  • Palo Alto University, CA, USA
  • 2017

related conditions:

Sleep

This report concludes CBD holds promise for significantly increasing the quality of REM sleep. Researchers believe it could one day be a primary force behind improved overall sleep quality. CBD was even shown to reduce daytime sleepiness in many patients.

Parkinson's & CBD Research Overview

CBD has quickly grown into a massive industry, in part, thanks to the wide range of conditions it's been shown to improve. That said, we're only just starting to uncover everything there is to know about the impact of CBD.

CBD is a cannabinoids extract, and cannabinoids have been suggested to have promising therapeutic effects that target the mechanistic pathways that underlie PD. Some researchers have argued that cannabinoids are capable of acting in an anti-oxidant fashion, thereby opposing oxidative stress at the mitochondrion.

That there is a physiological connection between cannabinoid's regulation of functions of metabolism and mitochondrial in energetics and motion is a plausible mechanism that could be dysregulated in PD pathology.

PD compromises the brain region associated with motion, and this area of the brain also have cannabinoid receptors, with the globus pallidus, and substantia nigra pars reticulate showing some of the highest CB1 receptor expression levels in the brain. CB2 receptors have also been found in the basal ganglia region that also expresses the ionotropic cannabinoid receptor TRPV1.

It has also been found that cannabinoids are pro-survival factors in neurons. These factors help protect against cell deaths induced by oxidation. That said, some researchers have argued that CB1 is not directly involved in the neuroprotective function of cannabinoids.

The anti-aggresomal factor of isolated cannabinoid compounds has also been proposed by researchers with suggestions that tetrahydrocannabinol can act as a direct binding agent to Aβ plaque peptides in Alzheimer's and causing disaggregation. It has also been shown that cannabinoids are pro-clearance agents that encourage autophagy and the dissolution of inclusion bodies. It is known by researchers that neuro-inflammation is a natural process of brain aging that is increased and proliferated in degenerative diseases such as PD.

Other research has suggested that a significant decrease in psychotic symptoms under CBD treatment for Parkinson's disease. Some researchers have contended that CBD did not worsen the motor function and decreased the total scores of the Unified Parkinson's Disease Rating Scale and that no adverse effect was observed during the trials.

These reports and data suggest that CBD may be a well-tolerated and effective treatment option for psychosis in PD.

Best CBD for Parkinson's

NoteCBD Capsules (10mg)

NoteCBD Capsules (10mg)

description

Enjoy the benefits of hemp extract with the convenience of a capsule. Each capsule contains a pre-portioned dose of full-spectrum hemp extract and MCT oil.

$45.00
  • CBD Per Serving: 10mg
  • Number Of Servings: 30
  • Cost Per Serving: $1.50
  • Cost Per/mg of CBD: $0.15
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advantages

  • Full Spectrum
  • Lab Certified
  • Organic
  Servings per day Days supplied in one package Cost per week
Low Dosage (5 mg/day) 0.50 60.0 $5.25
Mid Dosage (15 mg/day) 1.50 20.0 $15.75
High Dosage (30 mg/day) 3.00 10.0 $31.50

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NoteCBD Capsules (25mg)

NoteCBD Capsules (25mg)

description

Enjoy the benefits of hemp extract with the convenience of a capsule. Each capsule contains a pre-portioned dose of full-spectrum hemp extract and MCT oil.

$95.00
  • CBD Per Serving: 25mg
  • Number Of Servings: 30
  • Cost Per Serving: $3.17
  • Cost Per/mg of CBD: $0.13
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advantages

  • Full Spectrum
  • Gluten Free
  • Lab Certified
  Servings per day Days supplied in one package Cost per week
Low Dosage (5 mg/day) 0.20 150.0 $4.43
Mid Dosage (15 mg/day) 0.60 50.0 $13.30
High Dosage (30 mg/day) 1.20 25.0 $26.60

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Pure CBD Oil Capsules (15mg)

Pure CBD Oil Capsules (15mg)

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Every Day Optimal Soft Gel PCR Hemp Oil Capsule contains 15mg pure CBD from our proprietary high CBD strain of hemp.

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  • CBD Per Serving: 15mg
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  • Cost Per/mg of CBD: $0.13
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  Servings per day Days supplied in one package Cost per week
Low Dosage (5 mg/day) 0.33 90.0 $4.67
Mid Dosage (15 mg/day) 1.00 30.0 $14.00
High Dosage (30 mg/day) 2.00 15.0 $28.00

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Suggested CBD Dosage for Parkinson's

Dosage Per Day

Low

5 mg

Mid

15 mg

High

30 mg

Probably the most common question we get by far is how much CBD should be taken for a given condition. While it would be perfect if we could just give the precise dosage, the fact is each person is different and there’s no way the same dosages will work for everyone.

That said, the best way to find your ideal dosage is simply by experimenting until you find what works best. This is another way in which keeping a journal can be of a major benefit to you. And since CBD is non-psychoactive, you don’t have to worry about taking too much and ending up impaired.

Despite there not being a perfect dosage for everyone dealing with Parkinson’s, that doesn’t mean we aren’t able to give some insight into where to begin your experimentation. In a clinical trial, patients were given a dosage of dose of 150 mg per day. While CBD has grown into a well-respected medication in many parts of the country, there are still places that treat CBD the same as THC. In these places, you can get in serious trouble if you’re found in possession of CBD products, so always be sure to do your research before traveling with your CBD.

It’s also important to keep in mind that not all CBD products are 100% THC free. Some conditions are known to be more effectively treated when a little THC is still present along with the CBD. As such, you must make sure the products you buy are 100% CBD if you’re looking to avoid any psychoactive side-effects.

Just keep in mind, whatever type of CBD product you buy, the best thing you can do to improve its effectiveness is to keep a journal. It takes a little getting used too, but nothing else can make the transition quite as smooth as staying aware of how CBD is affecting your body.

This disclaimer informs readers that ONLY COMMENTARY expressed in this file belongs solely to Ahmed Diab, M.D., and not necessarily to the author’s employer, organization, committee, or other group or individual.

 

Commentary by Ahmed Diab M.D.

“CBD has not yet been shown to have a significant role to play in controlling neurodegenerative diseases like Parkinson’s. Chagas et al. have conducted a double-blind controlled trial and found no difference in UPDRS between CBD and Placebo. They did, however, find an improved PDQ-39 in patients taking CBD suggesting an association between CBD and improved quality of life for Parkinson patients.”

Tracking CBD Effectiveness For Parkinson's

For most people, it can seem pretty intimidating figuring out how to track the effectiveness of CBD. While it’s true that for many conditions, it can be challenging to notice the effect of CBD right away, Parkinson’s isn’t nearly as bad as others. Since for many, their symptoms are a prevalent part of their everyday lives; any change is usually very noticeable.

Regardless, it’s always constructive to start a journal to track your progress with CBD. Most people are amazed by how much of a difference, simply keeping track of their dosages and symptoms can make in understanding how it impacts you personally. For all the people who are wondering what’s the best way to identify any progress, this is it.

The bottom line is that each person is different and will have a slightly different response to CBD. Not only that, but for most people, it takes a bit of time until their body has fully acclimated to the new medication, and benefits become more evident. With just a few weeks of tracking your progress, you’ll be amazed at how much better you’ll understand how CBD affects you.

If you’re looking to zero in on exactly how CBD works for you or a loved one, be sure to start a journal. It may seem like a small thing to do when dealing with Parkinson’s disease, but if you simply pay attention to how CBD is impacting your tremors, inflammation, and stiffness over a few weeks, it can make a world of difference.

That said, if you do decide to keep track of your progress with CBD, we sincerely hope you consider leaving your experiences here for others looking to improve their quality of life. If you just leave a short description of your time using CBD, along with a score for how well it improved your tremors, inflammation, and stiffness, we can build the world’s strongest resource for people who want to learn about CBD.

Written By
John Alois
John Mace Alois is lead content creator at the Did CBD Work? project. He’s analyzed over 400 research papers related to Cannabidiol and helped publish over 55 works related to different conditions for the project. He majored in Cultural Anthropology, with a minor in English, from the University at Albany. He is an avid collector of art supplies and refurbishes old furniture in his spare time.
https://www.johnmacealois.com/
team@didcbdwork.com
Reviewed By*
Ahmed Diab, M.D.
Ahmed Diab, M.D is a graduate of Ain Shams University in Cairo, Egypt. Senior He is currently Senior Medical Writer at NegidaClin. He has written dozens of manuscripts for pharmaceutical enterprises. He published works also included drug safety and efficacy for those with Parkinsons Disease and a historical analysis of the performance of prostheses in femoral neck fractures.

*The information contained here does not constitute medical recommendations. Ahmed Diab does not recommend a certain dosage or a certain indication for any of our products. Please consult your personal physician before using any product.

PubMed.Gov Study
team@didcbdwork.com

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