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PTSD overview

Post-Traumatic Stress Disorder (PTSD) is an often debilitating mental condition triggered by either experiencing or witnessing a disturbing event. Individuals typically face daytime flashbacks and/or nightmares, along with severe anxiety associated with the experience.

While most people who go through a traumatic experience will temporarily experience difficulty coping, the majority of people begin to heal with some time and support. However, for some, adjusting can get harder over time, lasting months, and even years. Symptoms can become so severe individuals may be unable to carry out day-to-day activities, even ones they usually enjoy.

PTSD is a complex condition, with even the symptoms being quite varied. While symptoms of PTSD can start to present themselves within the first month after the event, it’s not uncommon for these symptoms to lie dormant for years until they begin to manifest.

There are four main types of PTSD, including acute stress disorder, uncomplicated PTSD, comorbid PTSD, and complex PTSD. Acute stress disorders are not actually PTSD. These are typically associated with experiencing a “life-threatening” event. However, unlike a normal stress response, acute stress disorders will develop into PTSD if left untreated.

Uncomplicated PTSD is generally the easiest form of PTSD to treat, as it’s associated with a single traumatic event, as opposed to an ongoing trauma, also known as complex PTSD. Both uncomplicated and complex PTSD typically involve avoidance of similar situations, as well as flashbacks to the event, or events. Finally, comorbid PTSD covers individuals who are suffering from multiple different conditions alongside their PTSD symptoms.

Other risk factors for developing PTSD are still being researched, but experts believe a history of depression or anxiety can significantly increase your chances of developing PTSD after a trauma. The reason our brains respond this way is also still being understood.

Many believe PTSD results from a defect in our survival mechanism, which keeps traumatic experiences fresh in our minds. However, some studies have shown people with PTSD tend to have abnormally higher stress hormone levels, while others show those with PTSD usually have a smaller hippocampus, which may result in the recurring flashbacks.

Nearly 9 million adults in the US are currently dealing with some form of PTSD or around 3.5%. Statistics show that women are almost twice as likely to experience PTSD than men, but it can occur to anyone at any age.

Given the high rate of occurrence and debilitating symptoms, experts continue to work to uncover new and effective treatments for PTSD. If you or a loved one may be suffering from PTSD, it’s important to talk to your doctor as soon as possible. Only a medical professional can provide an accurate diagnosis, along with the most relevant treatment options.

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Table of Contents

CBD Research For PTSD

potencial impact research overview

PTSD- The endocannabinoid system provides an avenue for evidence-based treatment development for PTSD

  • New York University
  • 2012

related conditions:

PTSD

Researchers wanted to uncover more well-tuned treatment options for those dealing with trauma. They found that CBD can significantly impact the effects of traumatic events on depression and anxiety. In fact, they found mitigating disruption in the CB1 receptor with CBD can greatly improve fear extinction, providing substantial evidence it’s a therapeutic treatment for fear-related stress disorders.

PTSD - Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the World Trade Center attacks

  • University of Calgary
  • 2013

related conditions:

PTSD

Research has concluded CBD receptors are integral in our ability to adapt to stress. This study found evidence that a deficit in the CB receptors could be directly tied to prolonged stress-related responses. Their data confirms what has been shown in animal models, that taking CBD can promote circulating levels of eCB 2-AG, known to mitigate stress levels.

PTSD - Enhancing cannabinoid neurotransmission augments the extinction of conditioned fear

  • Emory University
  • 2005

related conditions:

PTSD

Previous research has concluded that the eCB system plays an integral role as a therapeutic treatment for various anxiety disorders. The team wanted to see how CB1 blockage would affect the fear response of mice models. They found the eCB system can be modulated and positively enhanced to increase emotional learning, which suggests the possibility of CBD as a treatment for chronic stress disorders.

PTSD - Cannabidiol blocks long-lasting behavioral consequences of predator threat stress: possible involvement of 5HT1A receptors

  • University of Sao Paulo
  • 2012

related conditions:

PTSD

The researchers wanted to determine how effectively CBD can help treat PTSD-related anxiety symptoms. Rat models were exposed to predators, which is known to produce a long-lasting anxiogenic effect similar to PTSD. After exposure, some were given CBD daily before an elevated maze test seven days later. Their results indicate that CBD has a strong potential benefit for those suffering from anxiety conditions, such as PTSD.

PTSD - Stress switches cannabinoid type-1 (CB1) receptor-dependent plasticity from LTD to LTP in the bed nucleus of the stria terminalis

  • University Bordeaux Segalen
  • 2013

related conditions:

PTSD

The team wanted to further understand the connection between the functionality of the endocannabinoid system and the ability to handle stressful situations. The team tested mice models which lacked CB1 receptors, compared with normal controls. The deficit group showed a marked lower ability develop plasticity under stressful situations, and even in control tests. These results support the value of CBD to help regulate our endocannabinoid system.

PTSD - Mitigation of post-traumatic stress symptoms by Cannabis resin: a review of the clinical and neurobiological evidence

  • Hannover Medical School
  • 2012

related conditions:

PTSD

A case report of a 19-year-old, suffering from a range of PTSD and anxiety-based symptoms makes a strong case for the efficacy of CBD and other cannabinoids to treat these conditions. After starting on a cannabis regimen, the subject reported a significant reduction in the intensity of flashbacks, panic attacks, and an urge for self-mutilation. The researchers believe cannabinoids, and the endocannabinoid system, may play a pivotal role in fear extinction and antidepressive effects.

PTSD - Cannabinoid modulation of fear extinction brain circuits: a novel target to advance anxiety treatment

  • University of Michigan
  • 2014

related conditions:

PTSD

Researchers wanted a much deeper understanding of how the endocannabinoid system effects fear extinction and retention. Their evidence suggests enhancing the CBD transmission may indeed allow greater fear extinction in those suffering from anxiety-based conditions, such as PTSD. In fact, they believe CBD could be most effective as a supplement to exposure-based behavioral treatments.

PTSD - The endocannabinoid system and extinction learning

  • Johannes Gutenberg-University Mainz
  • 2007

related conditions:

PTSD

This review of the current CBD data summarizes everything we currently know about the connection between the endocannabinoid system and controlling extinction learning related to conditions such as PTSD. The role of endocannabinoids on learning and memory are well known, but recent research has suggested there could be significant value in CBD to treat anxiety-based disorders.

PTSD - A current overview of cannabinoids and glucocorticoids in facilitating extinction of aversive memories: potential extinction enhancers

  • Federal University of Santa Catarina
  • 2013

related conditions:

PTSD

Researchers wanted to uncover the connection between CBD and increased fear extinction, especially concerning the CB1 receptors. The team found evidence that a regimen of CBD can significantly reduce retention of memories which have the potential to trigger trauma. They also believe the best possible application for CBD is likely as a supplement to exposure-based treatments.

PTSD - Cannabinoids and traumatic stress modulation of contextual fear extinction and GR expression in the amygdala-hippocampal-prefrontal circuit

  • University of Haifa
  • 2013

related conditions:

PTSD

There is growing evidence that cannabinoids can significantly improve our response to stressful situations. Previous research by the team has determined the CB1 and CB2 receptors both help to limit stress-induced impairment. Taking everything into account, the researchers believe the interaction between cannabinoids and the glucocorticoid systems has a major role to play in regulating emotional trauma.

PTSD - Non-Antidepressant Long-term Treatment in Post-Traumatic Stress Disorder (PTSD)

  • Hotel Dieu Hospital France
  • 2015

related conditions:

PTSD

There is a need for new and effective treatments for anxiety-based conditions, such as PTSD, as the most common procedures often leave patients symptomatic. This review of the available research looks into all the different options for treating PTSD that aren’t merely antidepressants. The team confirmed the efficacy of using additional treatments, such as CBD, for traditional exposure therapy.

PTSD - The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system

  • University of Sao Paulo
  • 2013

related conditions:

PTSD

Researchers wanted to know if CBD is helping improve hippocampal neurogenesis. They believed this benefit is what ultimately provides the decreased anxiety, even after exposure to stressful situations. Ultimately, their data provides strong evidence CBD does indeed improve the hippocampal neurogenic action in PTSD patients.

PTSD - Modulation of fear memory by dietary polyunsaturated fatty acids via cannabinoid receptors

  • National Institute of Neuroscience
  • 2014

related conditions:

PTSD

Researchers concluded anxiety-based disorders, such as PTSD, can be regulated significantly via CB1 receptors. These CBD sensitive receptors showed a distinct ability to mitigate fear memory in mice models. Interestingly, the team concluded CB1 function was dramatically improved by ingesting n-3 long-chain polyunsaturated fatty acid (PUFA).

CBD Research That Might Be Useful for Symptoms of PTSD

potencial impact research overview

Mood - Sub-chronic impact of cannabinoids in street cannabis on cognition, psychotic-like symptoms and psychological well-being

  • University College London, UK
  • 2012

related conditions:

Mood Disorders

A much lower rate of psychosis-like symptoms were found in those who used marijuana with contained both THC and CBD, compared with types high only in THC. Researchers conclude the CBD attenuates the psychotic-like effects, leading to a greater sense of well-being and an overall improved mood.

Sleep - Cannabis, Cannabinoids, and Sleep: a Review of the Literature

  • Palo Alto University, CA, USA
  • 2017

related conditions:

Sleep

This report concludes CBD holds promise for significantly increasing the quality of REM sleep. Researchers believe it could one day be a primary force behind improved overall sleep quality. CBD was even shown to reduce daytime sleepiness in many patients.

Mood Disorders- Acute Effects of a Single, Oral dose of d9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) Administration in Healthy Volunteers

  • University of Barcelona
  • 2012

related conditions:

Mood Disorders

Unlike THC, which was shown to have acute behavioural and physiological effects, CBD was proven safe and well tolerated by healthy patients. In fact, while THC was associated with higher risks of anxiety and dysphoria, there were no differences between the CBD and placebo on any negative symptomatic variable.

PTSD & CBD Research Overview

People all over the world have been learning how much CBD can improve their PTSD symptoms. Over the last several years, the CBD industry has exploded in popularity, in part due to the increased interest in independent research on the effects of CBD. PTSD is a challenging condition to deal with, so anything which may improve the lives of those suffering is a welcome addition.

One thing the research has been very clear about is the impact of CB1 receptors on the impact of PTSD. Researchers have known for quite a while now that a great way to stimulate the CB1 receptors is via CBD supplements. In fact, a report called The endocannabinoid system provides an avenue for evidence-based treatment development for PTSD concluded CBD can improve CB1 function so much that it should be seen as a viable treatment option for fear-related disorders, such as PTSD.

Other studies have determined how important CB1 and CB2 are in our ability to adapt to stress on the fly. Reductions in circulating endocannabinoid levels in individuals with post-traumatic stress disorder following exposure to the World Trade Center attacks showed clear evidence taking CBD significantly increases levels of eCB 2-AG, which can help reduce stress.

It’s clear that the CB1 receptor is integral to this positive impact, as studies such as Enhancing cannabinoid neurotransmission augments the extinction of conditioned fear, have shown. Researchers tested how deficits in CB1 impacts the fear response in mice. They found not only is the endocannabinoid system important, but supplementing it can significantly increase emotional learning.

When compared with normal test subjects, mice models who lacked the CB1 receptors were markedly less able to adapt under new and stressful situations. The researchers behind Stress switches cannabinoid type-1 (CB1) receptor-dependent plasticity from LTD to LTP in the bed nucleus of the stria terminalis, took these results as solid evidence CBD could be an effective treatment for conditions such as PTSD, which subjects patients to excessive stress.

In relation to specific PTSD symptoms, CBD has been shown in reports such as A current overview of cannabinoids and glucocorticoids in facilitating extinction of aversive memories: potential extinction enhancers to provide enhanced protection against memories which could trigger trauma. Interestingly, the researchers also believe the best application for CBD-based PTSD treatments is as a supplement to exposure therapy.

Other reports have reached similar conclusions, with Cannabinoids and traumatic stress modulation of contextual fear extinction and GR expression in the amygdala-hippocampal-prefrontal circuit, and Modulation of fear memory by dietary polyunsaturated fatty acids via cannabinoid receptors, both able to determine that a CBD regimen can significantly reduce sensitivity to triggering memories, and reducing the subsequent emotional trauma. Finally, a report called The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system, also found that CBD can improve the hippocampal neurogenesis, providing decreased anxiety, even after stressful situations.

The anti-anxiety benefits of CBD have been well documented, but now researchers are expanding their knowledge further to determine how it can improve the symptoms of PTSD. Reports such as Cannabidiol blocks long-lasting behavioral consequences of predator threat stress: possible involvement of 5HT1A receptors, and Cannabinoid modulation of fear extinction brain circuits: a novel target to advance anxiety treatment, both provide a deeper understanding of how CBD treatment can benefit those dealing with severe anxiety.

In fact, a case study of a 19-year-old, called Mitigation of post-traumatic stress symptoms by Cannabis resin: a review of the clinical and neurobiological evidence, showed CBD significantly reduced the intensity of flashbacks, panic attacks, and the urge to self mutilate due to exposure of triggers.

Reviews of the available research, including The endocannabinoid system and extinction learning, and Non-Antidepressant Long-term Treatment in Post-Traumatic Stress Disorder (PTSD) show that not only do we require new and effective treatments for conditions such as PTSD, but CBD is an extremely viable option thanks, in part, to its neuroprotective properties.

Other reports have shown additional ways in which CBD is an effective treatment option for PTSD. Sub-chronic impact of cannabinoids in street cannabis on cognition, psychotic-like symptoms and psychological well-being concluded CBD reduces the frequency of psychosis-like symptoms, leading to an increased sense of well-being.

Sleep issues are another problem that often plagues those with PTSD, but luckily CBD has been shown to significantly improve REM sleep in humans. A report called Cannabis, Cannabinoids, and Sleep: a Review of the Literature indicated CBD may one day be a vital tool in improving sleep quality for all types of people, especially those dealing with debilitating conditions.

Finally, unlike some other medications for anxiety-based conditions like PTSD, which are sometimes aren’t well tolerated, CBD has been proven safe and effective time and time again. In fact, Acute Effects of a Single, Oral dose of d9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) Administration in Healthy Volunteers, concludes unlike THC, CBD use is not associated with higher risks of anxiety and dysphoria.

Best CBD for PTSD

NoteCBD Capsules (25mg)

NoteCBD Capsules (25mg)

description

Enjoy the benefits of hemp extract with the convenience of a capsule. Each capsule contains a pre-portioned dose of full-spectrum hemp extract and MCT oil.

$95.00
  • CBD Per Serving: 25mg
  • Number Of Servings: 30
  • Cost Per Serving: $3.17
  • Cost Per/mg of CBD: $0.13
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advantages

  • Full Spectrum
  • Gluten Free
  • Lab Certified
  Servings per day Days supplied in one package Cost per week
Low Dosage (10 mg/day) 0.40 75.0 $8.87
Mid Dosage (20 mg/day) 0.80 37.5 $17.73
High Dosage (30 mg/day) 1.20 25.0 $26.60

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Pure CBD Oil Capsules, (50mg)

Pure CBD Oil Capsules, (50mg)

description

Every Day Optimal Soft Gel PCR Hemp Oil Capsule contains 50mg of pure CBD.

$119.99
  • CBD Per Serving: 50mg
  • Number Of Servings: 30
  • Cost Per Serving: $4.00
  • Cost Per/mg of CBD: $0.08
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advantages

  • Easy Capsule Form
  • All Natural
  • GMP Compliant
  Servings per day Days supplied in one package Cost per week
Low Dosage (10 mg/day) 0.20 150.0 $5.60
Mid Dosage (20 mg/day) 0.40 75.0 $11.20
High Dosage (30 mg/day) 0.60 50.0 $16.80

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Pure CBD Oil Capsules (15mg)

Pure CBD Oil Capsules (15mg)

description

Every Day Optimal Soft Gel PCR Hemp Oil Capsule contains 15mg pure CBD from our proprietary high CBD strain of hemp.

$59.99
  • CBD Per Serving: 15mg
  • Number Of Servings: 30
  • Cost Per Serving: $2.00
  • Cost Per/mg of CBD: $0.13
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advantages

  • Easy Capsule Form
  • No GMO
  • All Natural
  Servings per day Days supplied in one package Cost per week
Low Dosage (10 mg/day) 0.67 45.0 $9.33
Mid Dosage (20 mg/day) 1.33 22.5 $18.66
High Dosage (30 mg/day) 2.00 15.0 $28.00

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Suggested CBD Dosage for PTSD

Dosage Per Day

Low

10 mg

Mid

20 mg

High

30 mg

Probably the most common question we ever get is precisely how much CBD should be taken for a given condition. While it would be fantastic if we could simply provide a cure-all answer for each issue, things aren’t quite that simple. Finding the ideal dosage for you is going to require a bit of experimentation.

Luckily, since CBD is a non-psychoactive substance, you don’t have to worry about any impairing effects from taking a little too much. Each person has a unique system that may require a different regimen than others.

However, while we can’t provide a perfect dose for each person with PTSD, we have a solid foundation for you to start with. According to a report called Cannabidiol as a Therapeutic Alternative for Post-traumatic Stress Disorder: From Bench Research to Confirmation in Human Trials, anywhere between 12-25mg of CBD per day was shown to alleviate key symptoms, without any adverse side effects.

It’s important to remember that while CBD has exploded in popularity in most parts of the country, some places still treat CBD and THC as the same. As such, be careful whenever traveling, as your favorite CBD product could land you in hot water.

We should also mention that while most CBD products these days are CBD only, many are formulated with a bit of THC still included to bolster effects. For anyone who is uninterested, or unable, to get high, they should always double-check to only get THC free products.

No matter what you do, be sure to consider keeping a journal to track your progress. While it can seem a bit awkward at first, nothing will make your transition to taking CBD easier than keeping a little journal.

Tracking CBD Effectiveness For PTSD

Often one of the most challenging things for people to do when they first start taking CBD is understanding how well it’s working for them. Since the desired impact of CBD is relatively subtle, it can be hard to know how well it’s working at times. However, PTSD is such a debilitating condition that this tends to be less of a problem than with other conditions.

That said, the best thing you can do when starting on CBD is to keep a little journal. You don’t need to keep extremely detailed notes, just simply how much you took and how it made you feel. Many people are amazed when they realize how much insight this simple trick truly offers.

Since everyone is different, everyone’s going to have a slightly different experience with CBD. For some, it will only take a day or two until they feel serious relief, while for others, it could take a few weeks on a consistent regimen to start noticing a change.

While it can seem like an unnecessary or even trivial process at first, there really is no better way to uncover how CBD affects your body in a timely manner than keeping a journal. This is especially true when it comes to zeroing in on your ideal dosage, or routine.

If you do decide to keep a journal to track your progress, please consider leaving a short description of your experience here for others. You’d be surprised how helpful a brief description can be, along with a score for how well CBD impacted your panic attacks, anxiety, and trouble sleeping. Together we can build a better world!

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