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Rheumatism overview

Rheumatic diseases are a range of conditions that impact tendons, ligaments, bones, and muscles throughout the body. This includes many types of arthritis and other issues that can significantly impact your quality of life. While they tend to occur in older individuals, they’re known to occur at any age.

Most of these conditions are caused by immune system dysfunction, leading to tissue damage. While doctors aren’t entirely sure what causes this reaction, they’ve identified both genes and the environment as potential factors.

The most common symptoms of rheumatic diseases include joint pain, trouble moving, and general inflammation around the body. There are over 200 distinct types of rheumatism, with some of the most common being osteoarthritis, rheumatoid arthritis, lupus, gout, and scleroderma.

The precise causes of rheumatic diseases aren’t currently understood. As with most conditions, having a family history is one of the more impactful risk factors. Sex also appears to play a significant role, with women being more likely to develop some form of rheumatism than men. Some risk factors of rheumatism that we can control include things such as smoking, diet, and exercise. Living a healthy lifestyle is shown to reduce the risk of developing these conditions significantly.

Current estimates suggest that nearly 25% of the adult US population, or 54.4 million people, are currently living with some form of rheumatism. Making matters worse, researchers believe this number could jump to over 78 million in the next 20 years.

Anyone who’s worried they or a loved one could be dealing with rheumatism should seriously consider talking to a doctor. Only they can get you on the right path forward, with an accurate diagnosis. Rheumatism can be controlled, and quality of life significantly increased, but it requires the right treatment plan.

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Table of Contents

CBD Research For Rheumatism

potencial impact research overview

Rheumatism - Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress

  • University of Mississippi Medical Center
  • 2011

related conditions:


Excessive or unresolved oxidative stress can cause organ dysfunction or damage, and targeting oxidative stress has often proved problematic, given the complexities of various diseases and their associated immune response. The authors of this review discuss recent studies suggesting that CBD may be useful in treating a number of diseases and disorders known to involve immune activation and associated oxidative stress. These studies highlight the unique mechanisms associated with CBD and how its therapeutic potential holds promise as a prototype for the development of novel anti-inflammatory drugs.

Rheumatism - Efficacy, tolerability and safety of cannabinoids in chronic pain associated with rheumatic diseases

  • McGill University Health Centre
  • 2016

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Researchers review randomized controlled trials from a limited set of databases that attempt to use cannabinoids to treat chronic pain associated with various rheumatic diseases. Their research notes cannabinoids were generally well-tolerated and safe during the various studies durations. They conclude that at the time of publishing, there is insufficient evidence for recommending cannabinoids in managing chronic pain associated with rheumatic diseases, but it is growing.

Rheumatism - Clinical Implications for Cannabinoid Use in the Rheumatic Diseases

  • American College of Rheumatology
  • 2012

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This review highlights the potential of cannabinoids as therapeutic agents in the treatment of rheumatic diseases and the management of their symptoms. Authors showcase studies noting the anti-inflammatory and analgesic properties of cannabinoids, such as CBD, and their potential benefit to those living with rheumatic diseases. They ultimately advocate for well-controlled clinical studies to better understand the therapeutic potential of cannabinoids for rheumatic diseases and their associated symptoms.

Rheumatism - Cannabinoids in the Management of Musculoskeletal or Rheumatic Diseases

  • McGill University Health Centre
  • 2016

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The authors of this review examine current evidence surrounding the efficacy and potential adverse effects of using exogenous cannabinoids to treat rheumatic conditions. They claim that the risks of herbal cannabis are not well defined, although they do not explain how. The review concludes that the evidence is currently scant, which precludes making recommendations for using cannabinoid preparations to treat rheumatology patients.

CBD Research That Might Be Useful for Symptoms of Rheumatism

potencial impact research overview

Anxiety - Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence

  • University of Melbourne, Australia
  • 2013

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A comprehensive review of all the plant-based medicine which has had both preclinical and human clinical trials conducted about their anxiolytic-like effect. An analysis of over 1500 papers identified 21 plants which had been adequately tested, with one of the most successful of these plants found to be CBD enriched Cannabis species.

Inflammation - Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice

  • Tongji University School of Medicine
  • 2013

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A study of mice concluded CBD has significant anti-inflammatory effects. The researchers also saw evidence that the expression of the GPR55 receptor was improved after starting on CBD. Treatment with CBD was shown to significantly decrease the levels of several inflammation-related chemicals in test subjects.

Pain Relief - Control of pain initiation by endogenous cannabinoids

  • University of Naples Federico II
  • 1998

related conditions:

Pain Relief

Researchers concluded CBD significantly reduces discomfort and pain, in part, due to the interaction between two substances, PEA and anandamide. According to tests, they “act synergistically, reducing pain responses 100-fold more potently than each compound alone”.

Rheumatism & CBD Research Overview

It’s become quite clear over the last several years that CBD has a lot more to offer than we previously realized. Thanks to a growing pile of peer-reviewed evidence, we are now starting to get an idea for how much CBD can do, perhaps even for those with rheumatic diseases.

CBD has been shown to be a powerful treatment for general inflammation in the body. Reports such as Anti-inflammatory role of cannabidiol and O-1602 in cerulein-induced acute pancreatitis in mice, have not only shown that CBD has this impact, but identified the primary receptor behind this process. The team concluded activation of the GPR55 receptor with CBD was responsible for reducing the level of inflammation related chemicals in the body dramatically.

Studies looking into the relationship between inflammation and oxidative stress, have provided some promising results. Cannabidiol as an emergent therapeutic strategy for lessening the impact of inflammation on oxidative stress, highlighted some recent research suggesting CBD is a powerful treatment option for conditions related to immune activation, as well as it’s associated oxidative stress.

Another review of the available research, called Clinical Implications for Cannabinoid Use in the Rheumatic Diseases, showcased several reports about the anti-inflammatory power of CBD. They found enough encouraging data to advocate for further research into the potential of CBD to mitigate rheumatic conditions.

That said, not every report has found enough evidence to suggest CBD is an effective treatment for various types of rheumatism. The researchers behind Efficacy, tolerability and safety of cannabinoids in chronic pain associated with rheumatic diseases concluded CBD is extremely well tolerated, even in high doses. However, they did not feel there was enough evidence at the time of publishing to recommend cannabinoids for managing the chronic pain associated with rheumatism.

Reports like Cannabinoids in the Management of Musculoskeletal or Rheumatic Diseases have also attempted to make the case that CBD isn’t currently well-understood enough to be considered an effective treatment for the complications of rheumatic disorders. Other reports, including Control of pain initiation by endogenous cannabinoids, have instead suggested this lack of consistency may be caused by the interaction between CBD and two related cannabinoids, PEA and anandamide. Primarily because this interaction is known to elicit a much more potent pain relieving effect than CBD does alone.

Finally, a much more subtle way in which CBD could improve the lives of those living with rheumatism is by reducing the commonly associated anxiety. Many reports, including Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence, have highlighted this benefit of CBD. In fact, researchers looked at over 1500 papers before concluding CBD is the single most powerful plant-based medication for anxiety we’ve identified.

Best CBD for Rheumatism

Everyday Optimal CBD Capsules (200mg)

Everyday Optimal CBD Capsules (200mg)


Are you looking for something stronger than almost any CBD oil product on the market? Then you’ll love the newest addition to our high potency CBD line. With each capsule containing 200mg of pure CBD, you’ll experience all-natural, long-lasting relief for tough pain, sleep problems, anxiety, and more.

  • CBD Per Serving: 200mg
  • Number Of Servings: 30
  • Cost Per Serving: $10.00
  • Cost Per/mg of CBD: $0.05
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  • Highest Capsule In USA
  • 100% USA Made
  • THC Free
  Servings per day Days supplied in one package Cost per week
Low Dosage (10 mg/day) 0.05 600.0 $3.50
Mid Dosage (30 mg/day) 0.15 200.0 $10.50
High Dosage (80 mg/day) 0.40 75.0 $28.00

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NoteCBD Tincture (250mg)

NoteCBD Tincture (250mg)


Support your health and wellness with CBD-infused tinctures specifically formulated for human consumption. This tincture is made with full spectrum hemp oil, MCT oil, and essential oils.

  • CBD Per Serving: 8.33mg
  • Number Of Servings: 30
  • Cost Per Serving: $1.50
  • Cost Per/mg of CBD: $0.18
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  • Full Spectrum Extract
  • Lab Certified
  • Made In USA
  Servings per day Days supplied in one package Cost per week
Low Dosage (10 mg/day) 1.20 25.0 $12.61
Mid Dosage (30 mg/day) 3.60 8.3 $37.82
High Dosage (80 mg/day) 9.60 3.1 $100.84

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Pure CBD Oil Capsules, (50mg)

Pure CBD Oil Capsules, (50mg)


Every Day Optimal Soft Gel PCR Hemp Oil Capsule contains 50mg of pure CBD.

  • CBD Per Serving: 50mg
  • Number Of Servings: 30
  • Cost Per Serving: $4.00
  • Cost Per/mg of CBD: $0.08
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  • Easy Capsule Form
  • All Natural
  • GMP Compliant
  Servings per day Days supplied in one package Cost per week
Low Dosage (10 mg/day) 0.20 150.0 $5.60
Mid Dosage (30 mg/day) 0.60 50.0 $16.80
High Dosage (80 mg/day) 1.60 18.8 $44.80

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Suggested CBD Dosage for Rheumatism

Dosage Per Day


10 mg


30 mg


80 mg

By far, the most common question we get is how much CBD needs to be taken to treat a given type of condition, such as rheumatic disorders. We truly wish that it were that simple, and we had an easy answer for everyone. However, what it really takes is a little bit of trial and error from the user.

While we don’t have the exact answer for everyone, we can offer a solid jumping-off point. According to experts at rheumatoidarthritis.org, starting out with between 10-20mg of CBD per day can be enough to significantly improve symptoms. They also note those with more severe symptoms should try larger doses, upwards of 80mg per day.

It’s also important to mention that while CBD is a very common thing in most parts of the country these days, that’s not the case everywhere. Many local laws actually treat CBD the same as it would THC, making it varying degrees of illegal. If you want to avoid any unwarranted trouble, be sure to look into the local laws before traveling with your CBD.

Another thing newcomers to CBD sometimes miss is that not all CBD products will be THC-free. Actually, some people find that a bit of THC can significantly improve the desired effects of CBD. However, if you’re not looking to risk being impaired, be sure to only purchase CBD-only products.

Whichever way you end up tracking your progress with CBD, or how much you take, please consider leaving those experiences here for others to learn from. There is so much information out there on CBD, and it can be very hard to know what is fact vs. fiction. User-generated reviews offer people a chance to see what others, just like them, are experiencing when trying CBD for the first time.

Tracking CBD Effectiveness For Rheumatism

Easily one of the most common problems we help people with is not knowing how well CBD is working for them. Most people find this extremely frustrating, but it’s important to know that you’re not alone. CBD has a subtle impact, which requires paying attention to understand fully. The only way to know for sure if CBD is going to work for you is by trying it for yourself and keeping a close watch on what happens.

The primary thing we suggest to those who are struggling with this problem is to start keeping a journal. All it takes is a brief overview of your daily symptoms, along with how much CBD you took that day. Most people are shocked by how much of a difference this simple little exercise can make.

There is a ton of value in reading about what other people have gone through, but at some point, you have to get out there yourself. Each person is far too unique for the same plan to work for everyone, so the only way to find your ideal plan is to work for it. You must start a regimen and pay attention to the results.

While you may wonder if keeping this journal is totally necessary, the truth is that nothing you can do so easily will make such a large impact. Of course, you could be successful without starting a journal, but if you’re already buying and trying CBD, why not do everything you can to improve the odds of success?

All it takes is a simple description of your time taking CBD, along with how it improved any pain, anxiety, or inflammation. In just a couple of minutes, you could provide the information which ultimately changes the life of someone in need.

Written By
John Mace Alois is lead content creator at the Did CBD Work? project. He’s analyzed over 400 research papers related to Cannabidiol and helped publish over 55 works related to different conditions for the project. He majored in Cultural Anthropology, with a minor in English, from the University at Albany. He is an avid collector of art supplies and refurbishes old furniture in his spare time.

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