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People who struggle with Schizophrenia, rated CBD highly in helping ease their condition.

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Schizophrenia overview

Schizophrenia is a very serious mental illness that can dramatically affect the way an individual interprets and interacts with the world around them. It can manifest as any combination of hallucinations, delusions, and vivid thoughts and feelings which have no apparent connection to reality.

If left unchecked, schizophrenia can prevent people from being able to live a functional life. Those diagnosed will need continued treatment throughout their lives. Early detection and intervention are associated with more favorable outcomes, and less severe complications developing.

The primary symptoms of schizophrenia can vary from person to person, but they all involve various issues with the regulation and control of thoughts, feelings, and behavior. Delusions are one of the more common cognitive problems associated with schizophrenia. These false beliefs can revolve around various topics, including being harmed or harassed, believing you’re incredibly important, having doomsday prophecies, and believing others are in love with you.

Hallucinations are another common symptom for those with schizophrenia. Patients may experience a genuine sensation of something happening to them, despite it not happening. While they can occur with any of the senses, audio hallucinations tend to be the most common.

Some living with schizophrenia will have trouble communicating because of disorganized thoughts and speech. While for others, their illness may exhibit itself with childlike or unpredictable behavior, an inability to perform basic hygiene, or an apparent lack of emotion.

Researchers don’t currently understand exactly what causes schizophrenia, but they believe it’s a combination of multiple factors, including genetics, brain chemistry, and even environment. One thing that’s been shown to be associated with schizophrenia is issues with neurotransmitters, including dopamine and glutamine.

The primary risk factors for schizophrenia are things that can’t be controlled, such as family history and certain birth complications. However, another factor researchers have shown may increase the risk of developing schizophrenia is taking powerful psychoactive drugs during adolescence and young adulthood.

Schizophrenia is a relatively uncommon condition, with estimates suggesting around 1.5 million people across the globe are diagnosed each year. This translates to about 100,000 Americans or about 14,000 in a city of two million. It’s rare for both young children and adults over 45 to develop schizophrenia, with most people diagnosed in their 20s.

Those living with schizophrenia will face a constant struggle, but the right combination of medication and therapy can make a world of difference. If you’re worried you or a loved one could be dealing with this, don’t hesitate to talk to a doctor. Only they can offer a full diagnosis, and get them on the path to a better life.

Be careful not to push too hard against someone unwilling to take help. That said, if you believe they could be a danger to themselves or someone else, you may need to call emergency responders to help get them evaluated by mental health professionals.

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Table of Contents

CBD Research For Schizophrenia

potencial impact research overview

Schizophrenia - Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug

  • University of Sao Paulo
  • 2006

related conditions:

Schizophrenia

Noting that CBD tends to counteract anxiogenic responses to THC, researchers explore the potential anxiolytic and/or antipsychotic properties of CBD. The team highlights multiple studies showcasing anxiolytic and antipsychotic-like properties of CBD, particularly case reports showing that CBD may be a safe and well-tolerated alternative treatment for schizophrenia. They conclude that CBD is an effective, safe, and well-tolerated alternative treatment for schizophrenia and may provide therapeutic potential for managing other psychotic conditions.

Schizophrenia - Cannabidiol as a potential treatment for psychosis

  • University Medical Centre Utrecht
  • 2014

related conditions:

Schizophrenia

In this review, the authors concisely provide an overview of currently available data investigating the antipsychotic properties of CBD. The team performed a targeted literature review searching for articles using Medline and EMBASE, featuring experiments with psychosis models, psychotic symptoms, or psychotic disorders as the outcome measure and involving the use of CBD as an intervention. The authors conclude that evidence from several research databases showcases the therapeutic potential of CBD in antipsychotic treatment.

Schizophrenia - Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia

  • Heidelberg University
  • 2012

related conditions:

Schizophrenia

This double-blind, randomized clinical trial compares CBD to amisulpride, a potent antipsychotic, in the treatment of acute schizophrenia. While both treatments were safe and led to significant clinical improvement, CBD displayed a markedly superior side-effect profile to amisulpride. These results suggest that the underlying mechanism behind the antipsychotic effects of CBD represents an entirely novel therapeutic target in the treatment of schizophrenia.

Schizophrenia - Medical use of cannabis. Cannabidiol: A new light for schizophrenia?

  • Boehringer Ingelheim Pharma GmbH
  • 2013

related conditions:

Schizophrenia

The authors of this review highlight the pharmacological and medicinal history of cannabis use dating as far back as 2,800 B.C. They highlight the potential antipsychotic properties of CBD, noting a lower side-effect profile than traditional antipsychotics. Their findings suggest CBD has a pharmacological profile similar to that of atypical antipsychotic drugs, and clinical trials show CBD is a well-tolerated alternative treatment for managing schizophrenia.

Schizophrenia - A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation

  • University of Sao Paulo
  • 2012

related conditions:

Schizophrenia

In this article, researchers provide a clinical review of research evaluating the antipsychotic potential of CBD. The team notes that CBD appears to have a pharmacological profile similar to atypical antipsychotics while having a remarkable safety and side-effect profile. Their results suggest that CBD may offer therapeutic potential in treating psychosis in general, and schizophrenia in particular.

Schizophrenia - Peripheral endocannabinoid system dysregulation in first-episode psychosis

  • Clinical and Provincial Hospital of Barcelona
  • 2013

related conditions:

Schizophrenia

This study compares endocannabinoid system regulation in a group with first-episode psychosis against a group of healthy controls. Researchers found that the endocannabinoid system appears dysregulated in patients who have suffered first-episode psychosis, and that continuous cannabis use could accentuate the malfunction of the endogenous cannabinoid system. They conclude that the modulation of the endocannabinoid system may be a promising therapeutic target in the treatment of psychotic disorders.

Schizophrenia - Cannabinoids and schizophrenia: Therapeutic prospects

  • GW Pharmaceuticals
  • 2014

related conditions:

Schizophrenia

The authors of this paper review the role of the endocannabinoid system in maintaining mental health, as well as its potential as a possible alternative treatment for schizophrenia. They highlight evidence from preclinical and clinical models highlighting their potential as novel atypical antipsychotic drugs. The preliminary data reviewed suggest that CBD, in combination with a CB1 antagonist, may not only augment traditional antipsychotic drugs, but also target the metabolic, inflammatory, and stress-related components of schizophrenia as well.

Schizophrenia - Antipsychotic-like effects of cannabidiol and rimonabant: Systematic review of animal and human studies

  • Ruhr-University Bochum
  • 2012

related conditions:

Schizophrenia

Preclinical studies and clinical trials investigated the antipsychotic effects of CBD and presented the possible underlying mechanisms of action. Analysts note that the pharmacological manipulation of the endogenous cannabinoid system may be associated with its potential antipsychotic properties. Their results confirm the hypothesis of the antipsychotic activity of CBD, noting it also has a pharmacological profile similar to that of atypical antipsychotic drugs.

Schizophrenia - Cannabidiol monotherapy for treatment-resistant schizophrenia

  • University of Sao Paulo
  • 2006

related conditions:

Schizophrenia

Researchers investigate the efficacy and safety of CBD monotherapy in patients with treatment-resistant schizophrenia. While CBD was regarded as safe and well-tolerated in the three patients sampled, only one displayed mild improvement. This preliminary data from a modest sample potentially suggests that CBD monotherapy may not be sufficient for managing treatment-resistant schizophrenia alone.

Schizophrenia - Cannabis with high cannabidiol content is associated with fewer psychotic experiences

  • University Medical Centre Utrecht
  • 2011

related conditions:

Schizophrenia

The objective of this web-based cross-sectional study is to investigate the role of CBD in the association between cannabis usage and psychiatric symptoms in a large non-clinical population of cannabis users. Researchers found an inverse relationship between CBD and self-reported positive symptoms, but not with negative symptoms or depression. Their results suggest that high-CBD cannabis was associated with significantly lower degrees of psychotic symptoms, providing support for the antipsychotic potential of CBD.

Schizophrenia - Marijuana compound treats schizophrenia with few side effects: Clinical trial

  • University of Cologne
  • 2012

related conditions:

Schizophrenia

In this study, researchers studied a group of people diagnosed with schizophrenia who were hospitalized for a psychotic episode. In a double-blind clinical trial, the patients were divided into two groups, one given amisulpride and one given CBD. Researchers found that not only was CBD as effective as the atypical antipsychotic but was also essentially free of the side effects typically associated with antipsychotic drugs.

Schizophrenia - Clearing the smoke: what do we know about adolescent cannabis use and schizophrenia?

  • University of Calgary
  • 2014

related conditions:

Schizophrenia

This article seeks to investigate any potential association between adolescent cannabis use and the development of schizophrenia. Authors state that such a hypothesis is without evidence, noting that while cannabis use has increased among the general population, the prevalence of schizophrenia has remained stable. They conclude that while there is little evidence supporting a link between cannabis use and schizophrenia, those diagnosed with schizophrenia should be warned of potential nontrivial issues linked to this condition and the use of cannabis.

CBD Research That Might Be Useful for Symptoms of Schizophrenia

potencial impact research overview

Anxiety - Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence

  • University of Melbourne, Australia
  • 2013

related conditions:

Anxiety

A comprehensive review of all the plant-based medicine which has had both preclinical and human clinical trials conducted about their anxiolytic-like effect. An analysis of over 1500 papers identified 21 plants which had been adequately tested, with one of the most successful of these plants found to be CBD enriched Cannabis species.

Mood Disorders- Acute Effects of a Single, Oral dose of d9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) Administration in Healthy Volunteers

  • University of Barcelona
  • 2012

related conditions:

Mood Disorders

Unlike THC, which was shown to have acute behavioural and physiological effects, CBD was proven safe and well tolerated by healthy patients. In fact, while THC was associated with higher risks of anxiety and dysphoria, there were no differences between the CBD and placebo on any negative symptomatic variable.

Sleep - Cannabis, Cannabinoids, and Sleep: a Review of the Literature

  • Palo Alto University, CA, USA
  • 2017

related conditions:

Sleep

This report concludes CBD holds promise for significantly increasing the quality of REM sleep. Researchers believe it could one day be a primary force behind improved overall sleep quality. CBD was even shown to reduce daytime sleepiness in many patients.

Schizophrenia & CBD Research Overview

There are a lot of reasons why CBD has grown into such a powerful industry over just the last couple of years. Not too long ago, few people had any idea about the power of CBD. One of the major factors has been the tireless research published on the various benefits, including for those dealing with schizophrenia.

There are plenty of reports which suggest CBD may be an effective treatment option for reducing anxiety and psychosis associated with schizophrenia. Even more importantly, most of these studies have also concluded that CBD is remarkably well tolerated by humans, even in high doses. For instance, Cannabidiol, a Cannabis sativa constituent, as an antipsychotic drug highlighted several studies which show CBD is a safe and well tolerated alternative for treating schizophrenia, and potentially other conditions.

Other studies, including Cannabidiol as a potential treatment for psychosis, and Medical use of cannabis. Cannabidiol: A new light for schizophrenia? have also reviewed currently available data to determine the antipsychotic properties of CBD. Countless reports, including anecdotal reports going back thousands of years, have concluded that cannabinoids like CBD are very safe for human use. Making them an attractive option over the heavy drugs used to treat psychosis.

A critical review of the antipsychotic effects of cannabidiol: 30 years of a translational investigation provided clinical research supporting this antipsychotic power of CBD. They concluded CBD seems to have a similar profile to more traditional antipsychotics, while being extremely well-tolerated.

Surveys of those living with schizophrenia, such as Cannabis with high cannabidiol content is associated with fewer psychotic experiences, have uncovered an inverse relationship between starting a CBD regimen and self-reported positive outcomes. Perhaps more importantly, those surveyed didn’t report any negative outcomes or increased depression.

Clinical trials of this impact, including Marijuana compound treats schizophrenia with few side effects: Clinical trial, have reached similar conclusions. The team observed two groups of individuals who were hospitalized during a psychotic episode. Not only was CBD found to be a safe option, but it was shown to be similarly effective as traditional treatments, without the usual side effects.

Other researchers have started to uncover the mechanisms by which CBD provides this effect. For instance, Cannabidiol enhances anandamide signaling and alleviates psychotic symptoms of schizophrenia, showed CBD was remarkably similar to a common antipsychotic used to treat schizophrenia, while having much more mild side-effects. Their double-blind, randomized trial concluded CBD had a superior side-effect profile, while the mechanism behind this effect was shown to potentially have therapeutic uses.

Studies comparing psychosis patients against healthy controls, such as Peripheral endocannabinoid system dysregulation in first-episode psychosis, have yielded robust data. The team found evidence that the endocannabinoid system was partially dysfunctional in first-episode psychosis patients. However, starting a regimen of cannabinoids, such as CBD, was shown to promote proper regulation of the endocannabinoid system. Researchers hope these treatments could one day be an important part of therapy for a variety of psychotic disorders.

Diving deeper, some experts have begun to observe which receptors are playing the largest role in the benefits of CBD for those with schizophrenia. Cannabinoids and schizophrenia: Therapeutic prospects found a properly regulated endocannabinoid system is one key to mental health. The preliminary data from preclinical and clinical models suggests CBD in combination with other CB1 antagonists can not only bolster effects of traditional antipsychotics, but also help treat some of the more subtle issues related to schizophrenia, including inflammation, stress management, and metabolic processes.

Another article supporting the value of CBD to help those with mental illness is Antipsychotic-like effects of cannabidiol and rimonabant: Systematic review of animal and human studies. The team of researchers noted supplementation of the endocannabinoid system with CBD was associated with several potential antipsychotic effects. They even found the pharmacological profile of CBD is quite similar to some atypical antipsychotics.

That said, not every paper has found lots of evidence supporting the power of CBD for schizophrenics. In fact, Cannabidiol monotherapy for treatment-resistant schizophrenia, showed that while CBD was very well-tolerated in humans, there isn’t enough evidence to say it improved schizophrenia symptoms on its own.

Some researchers have instead focused other questions surrounding the use of CBD and schizophrenia. For many years, rumors stated that using cannabis during adolescence could increase your risk of developing schizophrenia. Luckily, reports such as Clearing the smoke: what do we know about adolescent cannabis use and schizophrenia? have shown these concerns are flimsy at best. They believe any minor association noted is much more likely due to self medicating.

Reports such as Acute Effects of a Single, Oral dose of d9-tetrahydrocannabinol (THC) and Cannabidiol (CBD) Administration in Healthy Volunteers, have concluded CBD is a much better supplemental treatment option for those with psychosis disorders than THC, as it doesn’t have the same risk of increased anxiety.

In fact, reports have shown that CBD may be the single best all-natural anxiety medication we have at our disposal. According to, Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence, CBD was more effective at treating anxiety than any other plant based compound noted in the over 1500 papers analyzed.

Another common problem for those living with schizophrenia is extreme difficulty getting quality REM sleep. That said, reports like Cannabis, Cannabinoids, and Sleep: a Review of the Literature, have shown CBD treatment can dramatically improve overall sleep quality and even reduce daytime sleepiness.

Best CBD for Schizophrenia

Diamond CBD Full Spectrum Honey Tincture (2500mg)

Diamond CBD Full Spectrum Honey Tincture (2500mg)

description

These tasty new honey tinctures are made of 100% all-natural honey, presenting a delicious addition to how to deliver you with the ideal amount of CBD. Available in strengths ranging from 25mg to 3500mg, add it to your morning coffee, tea, or just use it throughout the day to sweeten up every moment while enjoying all of the awesome benefits that CBD offers.

$128.00
  • CBD Per Serving: 83.33mg
  • Number Of Servings: 30
  • Cost Per Serving: $4.27
  • Cost Per/mg of CBD: $0.05
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advantages

  • Honey Flavor
  • Control Over Dosing
  • All Natural Ingredients
  Servings per day Days supplied in one package Cost per week
Low Dosage (400 mg/day) 4.80 6.2 $143.37
Mid Dosage (600 mg/day) 7.20 4.2 $215.05
High Dosage (800 mg/day) 9.60 3.1 $286.73

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Everyday Optimal CBD Oil Tincture (4000mg)

Everyday Optimal CBD Oil Tincture (4000mg)

description

CBD oil comes in many forms and potencies, but we haven’t seen any product sold by our competitors as powerful as our 4000mg cbd oil tincture. We make this powerful hemp oil product for people who demand fast, sure-fire relief from severe symptoms.

$289.99
  • CBD Per Serving: 133.33mg
  • Number Of Servings: 30
  • Cost Per Serving: $9.67
  • Cost Per/mg of CBD: $0.07
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advantages

  • Fast Effective Relief
  • Zero THC
  • Made In USA
  Servings per day Days supplied in one package Cost per week
Low Dosage (400 mg/day) 3.00 10.0 $203.00
Mid Dosage (600 mg/day) 4.50 6.7 $304.50
High Dosage (800 mg/day) 6.00 5.0 $406.00

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Relax Full Spectrum CBD Oil (3500mg)

Relax Full Spectrum CBD Oil (3500mg)

description

Relax Full Spectrum CBD Oil, available with an oil tincture dropper, delivers the ideal amount of CBD to meet all of your wellness needs. Made in the USA  from 100% high quality industrial hemp, this 3500 mg bottle of CBD is perfect for those wanting to combat stress, anxiety, and chronic pain.

$168.00
  • CBD Per Serving: 116.67mg
  • Number Of Servings: 30
  • Cost Per Serving: $5.60
  • Cost Per/mg of CBD: $0.05
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advantages

  • 100% Hemp Product
  • Made in USA
  • Full Spectrum
  Servings per day Days supplied in one package Cost per week
Low Dosage (400 mg/day) 3.43 8.8 $134.40
Mid Dosage (600 mg/day) 5.14 5.8 $201.59
High Dosage (800 mg/day) 6.86 4.4 $268.79

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Suggested CBD Dosage for Schizophrenia

Dosage Per Day

Low

400 mg

Mid

600 mg

High

800 mg

The most common question we ever get is how much CBD should be taken to help a particular condition, such as schizophrenia. We wish we had the same answer to provide for everyone, but the truth is people are more complicated than that. Given the wide range of known and unknown, variables it's impossible to provide one answer that's right for everyone.

So while we don't have the exact answer, we can offer a solid starting point. According to some studies, 600mg of CBD may offer the same impact as amisulpride in treating psychotic symptoms, while having less negative side effects.

One thing worth mentioning is that even though CBD has become extremely common across the country, it's not legal everywhere. Some places still consider CBD to be, legally, the same as marijuana. That said, all you need to do is make sure you always check the local laws before taking CBD with you on your travels.

It's also important to note that not all CBD products will be THC-free. In fact, some people find a bit of THC included with the CBD can improve desired effects for certain conditions. However, if you can't be impaired, you must ensure you double-check everything before you buy.

No matter how you decide to take your CBD, we hope you decide to leave your experiences here for more people to learn from. We each have some insight to offer the next person, and together we can make the journey much easier.

Tracking CBD Effectiveness For Schizophrenia

One of the problems we see quite often is beginners having trouble understanding how well CBD is working for them. Most people find this frustrating, so never feel like you're doing something wrong. The truth is that even when working perfectly, for most conditions, the impact of CBD is relatively subtle and about change over time. As such, the best thing you can do to zero in on your ideal dosage is paying attention to what your body says.

One possible solution for anyone faced with this problem could be as simple as starting a journal. In fact, the number one thing we recommend to new users is keeping track of their daily doses along with how they felt that day. This one exercise has helped countless people find the right dose of CBD for them. If you're already going through the trouble of trying CBD, you owe it to yourself to try something simple that could make it all worth it.

Ultimately, each of our systems is slightly different and may react differently than others. This can be a particular problem for those with mental disorders, such as schizophrenia. As such, the only way to know for sure if CBD helps is to try it for yourself. The experience of others can be extremely valuable, but at the end of the day, you need to do the experiments for yourself.

Some people wonder if this whole journal thing is really necessary. While you can absolutely be very successful taking CBD without doing this, we firmly believe nothing is going to improve your chances as easily.

However CBD ends up working for you, we really hope you consider leaving those experiences here for the next person to learn from. While other's experiences shouldn't be the only thing you look at, they provide some important insight into how it could impact your day-to-day life. If you do decide to leave your experience, all we need is a short description of your time taking CBD and a score for how well it improved any mood swings, anxiety, or trouble sleeping.

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