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Stress overview

When it’s under control, stress is a perfectly normal and even useful response. However, if it gets out of control and becomes chronic, stress can lead to a wide range of more severe issues with your relationships, work, and even your health.

Simply put, stress is what happens when your body releases chemicals which trigger its fight or flight response. For most people, this only occurs when you’re in a stressful situation, and afterward, your body is able to recover rather quickly. But if your stress response remains active for an extended period, it can directly lead to much more severe problems since the excess of stress hormones put so much wear on your body.

If you don’t get a handle on your stress levels, it’s been shown to cause serious health problems such as depression, high blood pressure, heart disease, heart attack, ulcers, and even more. Chronic stress is also known to lead to other less severe, but still troublesome problems, such as weight loss or gain, various types of upset stomach, skin conditions such as acne, and even fertility issues.

Stress can be a complicated issue because everyone has different specific triggers. However, work-related stress tops the list, with nearly half of all Americans saying they experience some level work-related stress. Even worse, a full 25% of workers say their job is the most significant source of stress in their lives.

Another major source of stress is life stresses, such as the death of a loved one, divorce, illness or injury, increased financial burden, or trauma. Any of these and many more can lead to severe chronic stress.

The last primary source of stress for the average person is overthinking and worrying. Stress is often self-induced by worrying about issues that will likely never become a reality. Things such as increased exposure to negative media coverage, change, or even just personal beliefs can significantly increase your stress levels without a direct event.

Figures have shown around 80% of Americans deal with stress either frequently (44%) or sometimes (35%) in their daily lives. This makes it an extremely prevalent issue, with only 4% of people saying they never feel stressed out.

One of the best things you can do for you or a loved one who’s dealing with chronic stress is to talk to a doctor about your treatment options. Getting professional help is always the right course of action, especially when symptoms become more severe. But before you do, let’s first take a close look at what peer-reviewed evidence on stress has to say.

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Table of Contents

CBD Research For Stress

potencial impact research overview

Stress- Endogenous cannabinoid signaling is essential for stress adaptation

  • University of British Columbia
  • 2010

related conditions:

Stress

The research found that CBD plays a significant role in mitigating wear from chronic stress in the body. They concluded the administration of CBD before the final stress induction test blocked the repeated stress-induced decline of corticosterone responses. They were able to show that a divergent relationship between two endocannabinoid ligands was at the heart of this regulation.

Stress- Regulation of endocannabinoid signaling by stress: implications for stress-related affective disorders

  • University of British Columbia
  • 2008

related conditions:

Stress

Researchers concluded that CBD could significantly decrease the adverse effects of prolonged stress, especially in regards to depression. The endocannabinoid system was shown to tonically constrain the activation of a key stress-related adrenal gland. During repeated exposure, the endocannabinoid system was still shown to dampen activity in stress circuits.

Stress- Functional interactions between stress and the endocannabinoid system: from synaptic signaling to behavioral output

  • The Rockefeller University
  • 2010

related conditions:

Stress

The data suggests CBD plays a significant role on multiple levels as both a regulator and effector of stress responses. The researchers concluded CBD is activating and terminating a distinct adrenal stress response in both acute and chronic cases of stress. The team even found evidence CBD is used by the body to modulate cognitive and emotional processes.

Stress- Neuromodulators, stress and plasticity: a role for endocannabinoid signalling

  • University of Calgary
  • 2014

related conditions:

Stress

There’s been an increasing amount of evidence that extended stress can modify neural circuits themselves. This report takes an in-depth look at the impact CBD has on stress-induced changes, as well as their plasticity in this system. Interestingly, they concluded significant flexibility is limited to early adolescence, indicating different types of control at various developmental stages.

Stress- Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress

  • University of British Columbia
  • 2005

related conditions:

Stress

One common problem that goes along with stress is cognitive function and flexibility. The researchers found CBD administration completely reversed cognitive impairment during the Morris water maze test. Their data suggests CBD could become a valuable tool in developing better stress responses from those with neuropsychiatric disorders.

Stress- Endocannabinoids and stress

  • Max Planck Institute of Psychiatry
  • 2011

related conditions:

Stress

The researchers took an in-depth look at how CBD impacts the HPA axis, which is known to be a fundamental hormonal response related to stress. They concluded CBD is particularly useful in allostatic states and during recovery processes. They believe more research is needed, but CBD should be seen as a promising treatment for chronic stress-related conditions.

Stress- Stress regulates endocannabinoid-CB1 receptor signaling

  • Medical College of Wisconsin
  • 2014

related conditions:

Stress

The data suggests the CB1 receptor is stress-responsive, and introduction of CBD can significantly decrease the chances of stress-related problems. CBD was shown to dampen the behavioral and endocrine effects of acute stress. The researchers also found repeated exposure to the same stress while taking CBD can result in a significant dampening of the stress response itself.

Stress- Chronic stress impairs α1-adrenoceptor-induced endocannabinoid-dependent synaptic plasticity in the dorsal raphe nucleus.

  • University at Buffalo
  • 2014

related conditions:

Stress

The researchers concluded chronic stress has an inhibiting effect on EPSC and the eCB-mediated depolarization suppression. CBD receptors were shown to have reduced effectiveness when under stress, which impairs the a1-AR LTD. The team also showed evidence of a connection between noradrenaline and synaptic strength and plasticity in the brain.

Stress- Endocannabinoid-mediated modulation of stress responses: physiological and pathophysiological significance

  • National University of Ireland
  • 2010

related conditions:

Stress

The report shows there is a viable connection between stress mitigating responses and the endocannabinoid system. Their data highlights a system in which specific brain activity is mitigated in order to facilitate positive responses to chronic stress. The team believes research should now be focused on understanding how to exploit the endocannabinoid system to treat a wide range of stress-related disorders.

Stress- Cannabinoid receptor activation prevents the effects of chronic mild stress on emotional learning and LTP in a rat model of depression

  • University of Haifa
  • 2014

related conditions:

Stress

The researchers were interested in whether or not CBD treatment could have a significant impact for those dealing with chronic stress. Researchers tracked several things during their study, including emotional learning, long-term potentiation in the brain, and depression. Their data clearly showed enhancement of the CBD receptors could provide a viable treatment for several of the negative side effects of chronic stress on the body.

Stress- Cannabinoids ameliorate impairments induced by chronic stress to synaptic plasticity and short-term memory

  • University of Haifa
  • 2013

related conditions:

Stress

This study was focused on if CBD treatment could reduce the impact of long-term effects of stress on memory and plasticity. The team also looked into how CBD affects other common symptoms of chronic stress, such as depression and anxiety. They determined CB1 receptors provide a beneficial impact and could be part of a viable treatment option for several stress-related cognitive impairments.

Stress- The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system

  • University of Sao Paulo
  • 2013

related conditions:

Stress

This report supports the anxiolytic value of CBD in stressed mice, especially in regards to its proneurogenic action in the adult hippocampus. They showed evidence CBD promotes progenitor proliferation, as well as cell cycle progression. Perhaps more importantly, repeated doses of CBD increased hippocampal progenitor proliferation and neurogenesis in test mice.

Stress- Low-frequency stimulation evokes serotonin release in the nucleus accumbens and induces long-term depression via production of endocannabinoid

  • University of Bologna
  • 2014

related conditions:

Stress

Research shows that eCB travels retrogradely through the system and binds to CB1 receptors, which help facilitate a significant decrease in stress-related depression symptoms. They set out to determine the relationship between eCB pathways and other receptor systems, especially serotonin. The team believes their results provide ample starting ground for further research into the underlying mechanisms behind this effect.

CBD Research That Might Be Useful for Symptoms of Stress

potencial impact research overview

Anxiety - Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence

  • University of Melbourne, Australia
  • 2013

related conditions:

Anxiety

A comprehensive review of all the plant-based medicine which has had both preclinical and human clinical trials conducted about their anxiolytic-like effect. An analysis of over 1500 papers identified 21 plants which had been adequately tested, with one of the most successful of these plants found to be CBD enriched Cannabis species.

Sleep - Cannabis, Cannabinoids, and Sleep: a Review of the Literature

  • Palo Alto University, CA, USA
  • 2017

related conditions:

Sleep

This report concludes CBD holds promise for significantly increasing the quality of REM sleep. Researchers believe it could one day be a primary force behind improved overall sleep quality. CBD was even shown to reduce daytime sleepiness in many patients.

Nausea- Effect of cannabinoids on lithium-induced vomiting in the Suncus murinus (house musk shrew)

  • Wilfrid Laurier University
  • 2004

related conditions:

Nausea

CBD was shown to suppress nausea at lower levels than THC, but both active ingredients effectively treated vomiting. Interestingly, this effect was reversed by SR-121716 for THC, but the anti-nausea effects of CBD were not impacted.

Stress & CBD Research Overview

More and more people are beginning to swear by the power of CBD to help alleviate issues in their lives. While small pockets of people have known about CBD for years, the last few years have really brought its value to the forefront.

Stress is one of the most prevalent problems in society today. CBD is not only shown to help improve stress itself, but also many of the problems which can arise when stress becomes chronic, such as depression and anxiety.

While more research is being conducted all the time, there’s a growing consensus CBD plays a vital role in controlling the effect of chronic stress on the body. In fact, a report called Endogenous cannabinoid signaling is essential for stress adaptation concluded taking CBD before a stress test can block the repeated stress-induced decline.

Other studies have begun to look into why this happens.

For instance, Functional interactions between stress and the endocannabinoid system: from synaptic signaling to behavioral output found evidence CBD plays an important role as both a regulator and effector of stress on the body. The team found a specific adrenal stress response, which allows CBD to terminate both acute and chronic stress. A different report, called Endocannabinoid-mediated modulation of stress responses: physiological and pathophysiological significance, found evidence of a clear connection between stress mitigating responses and CBD.

Another set of researchers looked into the relationship between the HPA axis and CBD. Their report called Endocannabinoids and stress, concluded CBD is especially useful during stress-induced recovery processes. So while more research is required, they believe CBD should be seen as a viable treatment option moving forward.

In fact, an article called, Cannabinoids ameliorate impairments induced by chronic stress to synaptic plasticity and short-term memory took a deep dive in order to determine if CBD is effective at reducing the long-term effects of chronic stress. After analyzing all their data, the team found CB1 receptors have a positive impact on several different stress-induced cognitive impairments, such as anxiety and depression.

While CBD has been shown many times to reduce stress symptoms themselves, it’s also important to know CBD can be an effective treatment for many of the issues which go along with chronic stress. Two of the most commonly referenced stress-induced problems are anxiety and depression, as their quality of life plummets.

Anxiety is a prevalent issue for many people, but when chronic stress becomes a factor, things can quickly get out of hand. A report called The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system was able to provide significant support for the anxiolytic benefits of CBD on stressed subjects. Even more importantly, higher doses were shown to provide a more significant effect on hippocampal progenitor proliferation.

A comprehensive review of the available research, called Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence, looked at over 1500 articles on plant-based treatments for anxiety. Impressively, the called CBD one of the single most effective treatments they found and suggested more research is undertaken.

Some studies have taken a broader approach and identified several different ways in which CBD can help improve common symptoms of stress. One report, called Cannabinoids ameliorate impairments induced by chronic stress to synaptic plasticity and short-term memory identified several ways in which CBD, and the CB1 receptor specifically, provide benefits for common stress-related symptoms, such as anxiety, depression, memory issues, and inflexibility.

Depression is an extremely troublesome side-effect of chronic stress, with many people finding it impossible to live fulfilling lives. A report called Low-frequency stimulation evokes serotonin release in the nucleus accumbens and induces long-term depression via production of endocannabinoid, shed some light on how CBD is helping those with stress-induced depression. They found that eCB can travel through the system and bind to CB1 receptors, which helps decrease depression symptoms.

Another article, entitled Regulation of endocannabinoid signaling by stress: implications for stress-related affective disorders, provided further insight into the impact of CBD on stress-induced depression. The team concluded the endocannabinoid system is able to constrain the activation of a critical stress-related adrenal gland. Impressively, even after repeated exposure, the CBD was still shown to reduce the activity in these neural circuits significantly.

CBD has been shown by other researchers to protect from some of the worst side effects of chronic stress. A report called Neuromodulators, stress and plasticity: a role for endocannabinoid signalling, provided evidence CBD reduces the neural circuit changes associated with extended periods of stress. Other reports, including Chronic stress impairs α1-adrenoceptor-induced endocannabinoid-dependent synaptic plasticity in the dorsal raphe nucleus, have highlighted a deep connection between stress-related noradrenaline and synaptic strength.

These types of improvements were associated with a complete reversal of cognitive impairment during the Morris water maze test, according to a report called Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress. They believe CBD is particularly valuable as a stress regulator for those with neuropsychiatric disorders.

Several other research articles have found evidence CBD reduces the chances of developing a stress-induced condition. For example, Stress regulates endocannabinoid-CB1 receptor signaling found repeated exposure to the same stress while on a CBD regimen dramatically reduces the stress response elicited over time.

Finally, CBD is also known to be a very effective treatment for the more mild symptoms of prolonged stress, such as trouble sleeping and upset stomach. A report called Cannabis, Cannabinoids, and Sleep: a Review of the Literature proved CBD can significantly improve REM sleep for those who have been having difficulty. Meanwhile, Effect of cannabinoids on lithium-induced vomiting in the Suncus murinus (house musk shrew) concluded CBD has anti-nausea benefits which aren’t reversed by SR-121716. Unlike the other major active ingredient in cannabis, THC.

Best CBD for Stress

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Fibromyalgia Relief CBD Capsules, 25mg CBD + Added Vitamins

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  • CBD Per Serving: 25mg
  • Number Of Servings: 60
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NoteCBD Capsules (25mg)

NoteCBD Capsules (25mg)

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Enjoy the benefits of hemp extract with the convenience of a capsule. Each capsule contains a pre-portioned dose of full-spectrum hemp extract and MCT oil.

$95.00
  • CBD Per Serving: 25mg
  • Number Of Servings: 30
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  • Cost Per/mg of CBD: $0.13
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Suggested CBD Dosage for Stress

Dosage Per Day

Low

15 mg

Mid

25 mg

High

50 mg

Another pervasive question we answer is what the precise dosage is required to treat a given condition. Unfortunately, the truth is that each person is different and may require relatively different treatments.

For most people, the best way to determine their ideal dosages is by pure experimentation. Since CBD isn’t a psychoactive substance, it’s very easy to try different things without worrying about any unintended consequences. This allows total freedom to try different combinations until you land on your perfect mix.

That said, we can still provide you with a basic range to help start your journey. According to a report by researchers at the University of Colorado, CBD is an invaluable tool for treating anxiety-related disorders, such as chronic stress.

The researchers were able to decrease the anxiety level in just under 80% of participants. The team gave the vast majority of subjects a 25mg CBD capsule once a day after breakfast, with a handful getting 50mg or 75mg pills instead depending on their size and history.

You should always keep in mind that even though CBD has become a super popular new medicine, it’s still a very illegal substance some places. Be sure to take the time and read the local laws before purchasing CBD products, and especially before traveling.

Finally, we always like to mention that even though the vast majority of CBD products don’t contain any THC, some do. In fact, some people find the benefits of CBD much more potent when combined with a bit of THC to balance things out. So it’s always important to double-check when buying your CBD if you can’t or don’t want to get high. Regardless of how you take your CBD, be sure to seriously consider keeping a journal. You’ll be amazed at how much of a difference it can make in your life.

Tracking CBD Effectiveness For Stress

You may be wondering what’s the best way to tell if CBD is working for you. It’s a crucial question and probably one of the most common we get. Stress can be a bit tricky to stay on top of, so paying close attention to your body is always the most important thing you can do.

Stress can be a bit more difficult to track than some other conditions. But it also happens to be an issue that CBD can help improve in several distinct ways. That’s why the best thing you can do to keep track of your progress with CBD is starting a daily log of your doses and symptoms.

Any new drug in your system is going to take some time to get used too, and the more information you arm yourself with, the better. This is especially true for stress, as CBD is not only shown to treat stress itself, but also common stress-induced conditions such as anxiety and trouble sleeping.

Given all the different ways in which CBD could be improving your stress symptoms, being able to go back and compare different days is an invaluable tool. For most people, this provides just enough insight to determine the ideal regimen.

However you decide to track your progress with CBD, we sincerely hope you choose to leave your experiences here for others to learn from. It will only take you a couple of minutes, but it could make a world of difference for someone who needs to get a handle on their stress level.

Just leave your experience below with a score for how well CBD improved each of your stress, anxiety, and depression levels. Working together, we can provide the necessary information to those who need it most!

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