Stress & CBD Research Overview
More and more people are beginning to swear by the power of CBD to help alleviate issues in their lives. While small pockets of people have known about CBD for years, the last few years have really brought its value to the forefront.
Stress is one of the most prevalent problems in society today. CBD is not only shown to help improve stress itself, but also many of the problems which can arise when stress becomes chronic, such as depression and anxiety.
While more research is being conducted all the time, there’s a growing consensus CBD plays a vital role in controlling the effect of chronic stress on the body. In fact, a report called Endogenous cannabinoid signaling is essential for stress adaptation concluded taking CBD before a stress test can block the repeated stress-induced decline.
Other studies have begun to look into why this happens.
For instance, Functional interactions between stress and the endocannabinoid system: from synaptic signaling to behavioral output found evidence CBD plays an important role as both a regulator and effector of stress on the body. The team found a specific adrenal stress response, which allows CBD to terminate both acute and chronic stress. A different report, called Endocannabinoid-mediated modulation of stress responses: physiological and pathophysiological significance, found evidence of a clear connection between stress mitigating responses and CBD.
Another set of researchers looked into the relationship between the HPA axis and CBD. Their report called Endocannabinoids and stress, concluded CBD is especially useful during stress-induced recovery processes. So while more research is required, they believe CBD should be seen as a viable treatment option moving forward.
In fact, an article called, Cannabinoids ameliorate impairments induced by chronic stress to synaptic plasticity and short-term memory took a deep dive in order to determine if CBD is effective at reducing the long-term effects of chronic stress. After analyzing all their data, the team found CB1 receptors have a positive impact on several different stress-induced cognitive impairments, such as anxiety and depression.
While CBD has been shown many times to reduce stress symptoms themselves, it’s also important to know CBD can be an effective treatment for many of the issues which go along with chronic stress. Two of the most commonly referenced stress-induced problems are anxiety and depression, as their quality of life plummets.
Anxiety is a prevalent issue for many people, but when chronic stress becomes a factor, things can quickly get out of hand. A report called The anxiolytic effect of cannabidiol on chronically stressed mice depends on hippocampal neurogenesis: involvement of the endocannabinoid system was able to provide significant support for the anxiolytic benefits of CBD on stressed subjects. Even more importantly, higher doses were shown to provide a more significant effect on hippocampal progenitor proliferation.
A comprehensive review of the available research, called Plant-based medicines for anxiety disorders, part 2: a review of clinical studies with supporting preclinical evidence, looked at over 1500 articles on plant-based treatments for anxiety. Impressively, the called CBD one of the single most effective treatments they found and suggested more research is undertaken.
Some studies have taken a broader approach and identified several different ways in which CBD can help improve common symptoms of stress. One report, called Cannabinoids ameliorate impairments induced by chronic stress to synaptic plasticity and short-term memory identified several ways in which CBD, and the CB1 receptor specifically, provide benefits for common stress-related symptoms, such as anxiety, depression, memory issues, and inflexibility.
Depression is an extremely troublesome side-effect of chronic stress, with many people finding it impossible to live fulfilling lives. A report called Low-frequency stimulation evokes serotonin release in the nucleus accumbens and induces long-term depression via production of endocannabinoid, shed some light on how CBD is helping those with stress-induced depression. They found that eCB can travel through the system and bind to CB1 receptors, which helps decrease depression symptoms.
Another article, entitled Regulation of endocannabinoid signaling by stress: implications for stress-related affective disorders, provided further insight into the impact of CBD on stress-induced depression. The team concluded the endocannabinoid system is able to constrain the activation of a critical stress-related adrenal gland. Impressively, even after repeated exposure, the CBD was still shown to reduce the activity in these neural circuits significantly.
CBD has been shown by other researchers to protect from some of the worst side effects of chronic stress. A report called Neuromodulators, stress and plasticity: a role for endocannabinoid signalling, provided evidence CBD reduces the neural circuit changes associated with extended periods of stress. Other reports, including Chronic stress impairs α1-adrenoceptor-induced endocannabinoid-dependent synaptic plasticity in the dorsal raphe nucleus, have highlighted a deep connection between stress-related noradrenaline and synaptic strength.
These types of improvements were associated with a complete reversal of cognitive impairment during the Morris water maze test, according to a report called Downregulation of endocannabinoid signaling in the hippocampus following chronic unpredictable stress. They believe CBD is particularly valuable as a stress regulator for those with neuropsychiatric disorders.
Several other research articles have found evidence CBD reduces the chances of developing a stress-induced condition. For example, Stress regulates endocannabinoid-CB1 receptor signaling found repeated exposure to the same stress while on a CBD regimen dramatically reduces the stress response elicited over time.
Finally, CBD is also known to be a very effective treatment for the more mild symptoms of prolonged stress, such as trouble sleeping and upset stomach. A report called Cannabis, Cannabinoids, and Sleep: a Review of the Literature proved CBD can significantly improve REM sleep for those who have been having difficulty. Meanwhile, Effect of cannabinoids on lithium-induced vomiting in the Suncus murinus (house musk shrew) concluded CBD has anti-nausea benefits which aren’t reversed by SR-121716. Unlike the other major active ingredient in cannabis, THC.